Feasibility of Prehabilitation Prior to Breast Cancer Surgery: A Mixed-Methods Study
BackgroundBreast cancer surgery results in numerous acute and long-term adverse outcomes; the degree to which these can be mitigated or prevented through prehabilitation is unknown.MethodsWe conducted a longitudinal, single-arm, mixed-methods study to examine the feasibility of prehabilitation in 22...
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Frontiers Media S.A.
2020-09-01
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Series: | Frontiers in Oncology |
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Online Access: | https://www.frontiersin.org/article/10.3389/fonc.2020.571091/full |
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doaj-46d0bcef8d554eee8cc5f557598d6e98 |
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Article |
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DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Priya Brahmbhatt Priya Brahmbhatt Catherine M. Sabiston Christian Lopez Eugene Chang Eugene Chang Jack Goodman Jennifer Jones Jennifer Jones David McCready David McCready Ian Randall Ian Randall Sarah Rotstein Daniel Santa Mina Daniel Santa Mina Daniel Santa Mina |
spellingShingle |
Priya Brahmbhatt Priya Brahmbhatt Catherine M. Sabiston Christian Lopez Eugene Chang Eugene Chang Jack Goodman Jennifer Jones Jennifer Jones David McCready David McCready Ian Randall Ian Randall Sarah Rotstein Daniel Santa Mina Daniel Santa Mina Daniel Santa Mina Feasibility of Prehabilitation Prior to Breast Cancer Surgery: A Mixed-Methods Study Frontiers in Oncology prehabilitation breast cancer survivorship rehabilitation oncology surgery |
author_facet |
Priya Brahmbhatt Priya Brahmbhatt Catherine M. Sabiston Christian Lopez Eugene Chang Eugene Chang Jack Goodman Jennifer Jones Jennifer Jones David McCready David McCready Ian Randall Ian Randall Sarah Rotstein Daniel Santa Mina Daniel Santa Mina Daniel Santa Mina |
author_sort |
Priya Brahmbhatt |
title |
Feasibility of Prehabilitation Prior to Breast Cancer Surgery: A Mixed-Methods Study |
title_short |
Feasibility of Prehabilitation Prior to Breast Cancer Surgery: A Mixed-Methods Study |
title_full |
Feasibility of Prehabilitation Prior to Breast Cancer Surgery: A Mixed-Methods Study |
title_fullStr |
Feasibility of Prehabilitation Prior to Breast Cancer Surgery: A Mixed-Methods Study |
title_full_unstemmed |
Feasibility of Prehabilitation Prior to Breast Cancer Surgery: A Mixed-Methods Study |
title_sort |
feasibility of prehabilitation prior to breast cancer surgery: a mixed-methods study |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Oncology |
issn |
2234-943X |
publishDate |
2020-09-01 |
description |
BackgroundBreast cancer surgery results in numerous acute and long-term adverse outcomes; the degree to which these can be mitigated or prevented through prehabilitation is unknown.MethodsWe conducted a longitudinal, single-arm, mixed-methods study to examine the feasibility of prehabilitation in 22 women undergoing breast cancer surgery. All participants received an individualized exercise prescription including upper quadrant-specific resistance and mobility training and aerobic exercise for the duration of their surgical wait time. Feasibility was assessed by recruitment, adherence, attrition, and intervention-related adverse event rates. An exploratory investigation of intervention efficacy was conducted via a 6-min walk test, upper-quadrant strength and range of motion, volumetric chances associated with lymphedema, and participant-reported quality of life, fatigue, pain, and disability. Outcome assessments were conducted at baseline, prior to surgery, and at six and 12 weeks after surgery. Semi-structured interviews with a subset of participants (n = 5) and health-care providers (H; n = 2) were conducted to provide further insights about intervention feasibility. Qualitative data were analyzed using a hybrid inductive and deductive thematic analysis approach.ResultsRecruitment and attrition rates were 62 and 36%, respectively. Average prehabilitation duration was 31 days (range = 7–69 days). Seventy six percent of participants complied with at least 70% of their prehabilitation prescription. There was a clinically significant increase in the 6-min walk distance from baseline to the preoperative assessment (57 m, 95% CI = −7.52, 121.7). The interviews revealed that the intervention was favorably received by participants and HCPs and included suggestions that prehabilitation (i) should be offered to all surgical candidates, (ii) is an avenue to regain control in the preoperative period, (iii) is a facilitator of postoperative recovery, and (iv) is an opportunity to provide education regarding postoperative rehabilitation protocols. A preference for multimodal prehabilitation (including dietetic and psychological counseling) was also highlighted.ConclusionOur findings suggest that surgical prehabilitation in women with breast cancer is feasible. Data are hampered by study sample size and lack of a control group. Thus, randomized controlled trials to examine prehabilitation efficacy in people with breast cancer, especially interventions employing a multimodal strategy, are warranted. |
topic |
prehabilitation breast cancer survivorship rehabilitation oncology surgery |
url |
https://www.frontiersin.org/article/10.3389/fonc.2020.571091/full |
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doaj-46d0bcef8d554eee8cc5f557598d6e982020-11-25T03:40:33ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2020-09-011010.3389/fonc.2020.571091571091Feasibility of Prehabilitation Prior to Breast Cancer Surgery: A Mixed-Methods StudyPriya Brahmbhatt0Priya Brahmbhatt1Catherine M. Sabiston2Christian Lopez3Eugene Chang4Eugene Chang5Jack Goodman6Jennifer Jones7Jennifer Jones8David McCready9David McCready10Ian Randall11Ian Randall12Sarah Rotstein13Daniel Santa Mina14Daniel Santa Mina15Daniel Santa Mina16Faculty of Kinesiology and Physical Education, University of Toronto, Toronto, ON, CanadaDepartment of Supportive Care, Princess Margaret Cancer Centre, Toronto, ON, CanadaFaculty of Kinesiology and Physical Education, University of Toronto, Toronto, ON, CanadaDepartment of Supportive Care, Princess Margaret Cancer Centre, Toronto, ON, CanadaDepartment of Supportive Care, Princess Margaret Cancer Centre, Toronto, ON, CanadaFaculty of Medicine, University of Toronto, Toronto, ON, CanadaFaculty of Kinesiology and Physical Education, University of Toronto, Toronto, ON, CanadaDepartment of Supportive Care, Princess Margaret Cancer Centre, Toronto, ON, CanadaFaculty of Medicine, University of Toronto, Toronto, ON, CanadaFaculty of Medicine, University of Toronto, Toronto, ON, CanadaDepartment of Surgical Oncology, Princess Margaret Cancer Centre, Toronto, ON, CanadaFaculty of Medicine, University of Toronto, Toronto, ON, CanadaDepartment of Anesthesia and Pain Management, University Health Network, Toronto, ON, CanadaDepartment of Surgical Oncology, Princess Margaret Cancer Centre, Toronto, ON, CanadaFaculty of Kinesiology and Physical Education, University of Toronto, Toronto, ON, CanadaFaculty of Medicine, University of Toronto, Toronto, ON, CanadaDepartment of Anesthesia and Pain Management, University Health Network, Toronto, ON, CanadaBackgroundBreast cancer surgery results in numerous acute and long-term adverse outcomes; the degree to which these can be mitigated or prevented through prehabilitation is unknown.MethodsWe conducted a longitudinal, single-arm, mixed-methods study to examine the feasibility of prehabilitation in 22 women undergoing breast cancer surgery. All participants received an individualized exercise prescription including upper quadrant-specific resistance and mobility training and aerobic exercise for the duration of their surgical wait time. Feasibility was assessed by recruitment, adherence, attrition, and intervention-related adverse event rates. An exploratory investigation of intervention efficacy was conducted via a 6-min walk test, upper-quadrant strength and range of motion, volumetric chances associated with lymphedema, and participant-reported quality of life, fatigue, pain, and disability. Outcome assessments were conducted at baseline, prior to surgery, and at six and 12 weeks after surgery. Semi-structured interviews with a subset of participants (n = 5) and health-care providers (H; n = 2) were conducted to provide further insights about intervention feasibility. Qualitative data were analyzed using a hybrid inductive and deductive thematic analysis approach.ResultsRecruitment and attrition rates were 62 and 36%, respectively. Average prehabilitation duration was 31 days (range = 7–69 days). Seventy six percent of participants complied with at least 70% of their prehabilitation prescription. There was a clinically significant increase in the 6-min walk distance from baseline to the preoperative assessment (57 m, 95% CI = −7.52, 121.7). The interviews revealed that the intervention was favorably received by participants and HCPs and included suggestions that prehabilitation (i) should be offered to all surgical candidates, (ii) is an avenue to regain control in the preoperative period, (iii) is a facilitator of postoperative recovery, and (iv) is an opportunity to provide education regarding postoperative rehabilitation protocols. A preference for multimodal prehabilitation (including dietetic and psychological counseling) was also highlighted.ConclusionOur findings suggest that surgical prehabilitation in women with breast cancer is feasible. Data are hampered by study sample size and lack of a control group. Thus, randomized controlled trials to examine prehabilitation efficacy in people with breast cancer, especially interventions employing a multimodal strategy, are warranted.https://www.frontiersin.org/article/10.3389/fonc.2020.571091/fullprehabilitationbreast cancersurvivorshiprehabilitationoncologysurgery |