Long-Term Survival of Peritoneal Dialysis in Children: A Cohort Study

<span style="font-family: Times New Roman;"><strong><em>Background: </em></strong>There is little information about the survival rate of pediatric peritoneal dialysis (PD) patients and its risk factors. Therefore, the aim of the present study was to assess sur...

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Main Authors: Mahmoud Yousefifard, Neamatollah Ataei, Shahin Roshani, Fatemeh Darabi, Iraj Najafi, Mojtaba Fazel, Zeynab Talayi, Michael Jones, Mehdi Yaseri, Mostafa Hosseini
Format: Article
Language:English
Published: Mashhad University of Medical Sciences 2019-09-01
Series:International Journal of Pediatrics
Subjects:
Online Access:http://ijp.mums.ac.ir/article_13502_03823f4c3fd9d5d3b32a71432afed869.pdf
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spelling doaj-46da1af7d3224842aa6d58b0c4dd9e542020-11-25T01:58:18ZengMashhad University of Medical SciencesInternational Journal of Pediatrics2345-50472345-50552019-09-0179100091001710.22038/ijp.2019.41855.352513502Long-Term Survival of Peritoneal Dialysis in Children: A Cohort StudyMahmoud Yousefifard0Neamatollah Ataei1Shahin Roshani2Fatemeh Darabi3Iraj Najafi4Mojtaba Fazel5Zeynab Talayi6Michael Jones7Mehdi Yaseri8Mostafa Hosseini9Prevention of Cardivascular Disease Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.Pediatric Chronic Kidney Disease Research Center, Tehran University of Medical Sciences, Tehran, Iran AND Department of Pediatric Nephrology, Children’s Hospital Medical Center, Tehran University of Medical Sciences, Tehran, Iran.Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.Department of Public Health, Asadabad School of Medical Sciences, Asadabad, Iran.Nephrology Research Center, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran.Pediatric Chronic Kidney Disease Research Center, Tehran University of Medical Sciences, Tehran, Iran AND Department of Pediatric Nephrology, Children’s Hospital Medical Center, Tehran University of Medical Sciences, Tehran, Iran.Pediatric Department, Valiasr Hospital, Tehran University of Medical Sciences, Tehran, Iran.Division of Genetics and Epidemiology, The Institute of Cancer Research, London, UK.Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.1- Pediatric Chronic Kidney Disease Research Center, Tehran University of Medical Sciences, Tehran, Iran. 2- Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.<span style="font-family: Times New Roman;"><strong><em>Background: </em></strong>There is little information about the survival rate of pediatric peritoneal dialysis (PD) patients and its risk factors. Therefore, the aim of the present study was to assess survival rate and its risk factors in Iranian children undergoing PD. </span><br /> <span style="font-family: Times New Roman;"><strong><em>Materials and Methods: </em></strong>Demographic and laboratory data of 407 Iranian children (up to 19 years old) undergoing PD, from 20 centers in Iran were included. The outcome of interest in our study was survival rate and determination of its risk factors in PD children. The joint models of longitudinal and time-to-event data analysis was used. </span><br /> <span style="font-family: Times New Roman;"><strong><em>Results: </em></strong>The median duration of follow-up was 537 (interquartile range: 146 to 1,177) days. Finally, 72 (17.7%) patients died during a period of 23 years. Our results showed that one-year survival rate of PD patients was 93.6% and five-year survival rate was 76.9%. In addition, the most important risk factors for the PD all-cause mortality were age (HR=0.9301; 95% CI: 0.9031 to 0.9587), serum creatinine (HR=0.8907; 95% CI: 0.8138 to 0.9750), platelet count (HR=0.9999; 95% CI: 0.99995 to 0.99999), aspartate aminotransferase level (HR=1.0001; 95% CI: 0.9999, 1.0002), alkaline phosphatase (HR=0.9989; 95% CI: 0.9982 to 0.9997), renal solute clearance rate (HR=0.9839; 95% CI: 0.9700 to 0.9981), and normalized protein catabolic rate (HR=0.4031; 95% CI: 0.1879, 0.8648). </span><br /> <strong><em>Conclusion: </em></strong>The survival rate of Iranian pediatric PD patients is similar to other countries. It is suggested that laboratory assessment be continuallyhttp://ijp.mums.ac.ir/article_13502_03823f4c3fd9d5d3b32a71432afed869.pdfChildren, Mortality, Peritoneal Dialysis, SurvivalRisk factors
collection DOAJ
language English
format Article
sources DOAJ
author Mahmoud Yousefifard
Neamatollah Ataei
Shahin Roshani
Fatemeh Darabi
Iraj Najafi
Mojtaba Fazel
Zeynab Talayi
Michael Jones
Mehdi Yaseri
Mostafa Hosseini
spellingShingle Mahmoud Yousefifard
Neamatollah Ataei
Shahin Roshani
Fatemeh Darabi
Iraj Najafi
Mojtaba Fazel
Zeynab Talayi
Michael Jones
Mehdi Yaseri
Mostafa Hosseini
Long-Term Survival of Peritoneal Dialysis in Children: A Cohort Study
International Journal of Pediatrics
Children, Mortality, Peritoneal Dialysis, Survival
Risk factors
author_facet Mahmoud Yousefifard
Neamatollah Ataei
Shahin Roshani
Fatemeh Darabi
Iraj Najafi
Mojtaba Fazel
Zeynab Talayi
Michael Jones
Mehdi Yaseri
Mostafa Hosseini
author_sort Mahmoud Yousefifard
title Long-Term Survival of Peritoneal Dialysis in Children: A Cohort Study
title_short Long-Term Survival of Peritoneal Dialysis in Children: A Cohort Study
title_full Long-Term Survival of Peritoneal Dialysis in Children: A Cohort Study
title_fullStr Long-Term Survival of Peritoneal Dialysis in Children: A Cohort Study
title_full_unstemmed Long-Term Survival of Peritoneal Dialysis in Children: A Cohort Study
title_sort long-term survival of peritoneal dialysis in children: a cohort study
publisher Mashhad University of Medical Sciences
series International Journal of Pediatrics
issn 2345-5047
2345-5055
publishDate 2019-09-01
description <span style="font-family: Times New Roman;"><strong><em>Background: </em></strong>There is little information about the survival rate of pediatric peritoneal dialysis (PD) patients and its risk factors. Therefore, the aim of the present study was to assess survival rate and its risk factors in Iranian children undergoing PD. </span><br /> <span style="font-family: Times New Roman;"><strong><em>Materials and Methods: </em></strong>Demographic and laboratory data of 407 Iranian children (up to 19 years old) undergoing PD, from 20 centers in Iran were included. The outcome of interest in our study was survival rate and determination of its risk factors in PD children. The joint models of longitudinal and time-to-event data analysis was used. </span><br /> <span style="font-family: Times New Roman;"><strong><em>Results: </em></strong>The median duration of follow-up was 537 (interquartile range: 146 to 1,177) days. Finally, 72 (17.7%) patients died during a period of 23 years. Our results showed that one-year survival rate of PD patients was 93.6% and five-year survival rate was 76.9%. In addition, the most important risk factors for the PD all-cause mortality were age (HR=0.9301; 95% CI: 0.9031 to 0.9587), serum creatinine (HR=0.8907; 95% CI: 0.8138 to 0.9750), platelet count (HR=0.9999; 95% CI: 0.99995 to 0.99999), aspartate aminotransferase level (HR=1.0001; 95% CI: 0.9999, 1.0002), alkaline phosphatase (HR=0.9989; 95% CI: 0.9982 to 0.9997), renal solute clearance rate (HR=0.9839; 95% CI: 0.9700 to 0.9981), and normalized protein catabolic rate (HR=0.4031; 95% CI: 0.1879, 0.8648). </span><br /> <strong><em>Conclusion: </em></strong>The survival rate of Iranian pediatric PD patients is similar to other countries. It is suggested that laboratory assessment be continually
topic Children, Mortality, Peritoneal Dialysis, Survival
Risk factors
url http://ijp.mums.ac.ir/article_13502_03823f4c3fd9d5d3b32a71432afed869.pdf
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