The Role of the Caudate in Nonmotor Behaviors in Huntington’s Disease
Neuropsychologic data suggest an important role for the caudate nucleus (CN) in behavioral impairments in Huntington's disease (HD). These include abnormalities in executive function, egocentric visuospatial representations, communication, and retrieval of declarative memories, changes in perso...
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| Format: | Article |
| Language: | English |
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Hindawi Limited
1992-01-01
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| Series: | Behavioural Neurology |
| Online Access: | http://dx.doi.org/10.3233/BEN-1992-5402 |
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Article |
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doaj-46e3c3e03cdb467fa9bdd218a7eaac332021-07-02T02:06:47ZengHindawi LimitedBehavioural Neurology0953-41801875-85841992-01-015420521410.3233/BEN-1992-5402The Role of the Caudate in Nonmotor Behaviors in Huntington’s DiseaseD. H. Jacobs0S. J. Huber1Department of Neurology, University of Kansas School of Medicine, Kansas City, Kansas, USADepartment of Neurology, University of Kansas School of Medicine, Kansas City, Kansas, USANeuropsychologic data suggest an important role for the caudate nucleus (CN) in behavioral impairments in Huntington's disease (HD). These include abnormalities in executive function, egocentric visuospatial representations, communication, and retrieval of declarative memories, changes in personality, and psychiatric disturbances. Animal paradigms of CN lesions support a role for the CN in some of these behaviors. Current theories of basal ganglia function add explanatory value to the role of the CN in these behaviors. A disconnection of the caudate from limbic structures, including the amygdala may account for many nonmotor behaviors observed in HD.http://dx.doi.org/10.3233/BEN-1992-5402 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
D. H. Jacobs S. J. Huber |
| spellingShingle |
D. H. Jacobs S. J. Huber The Role of the Caudate in Nonmotor Behaviors in Huntington’s Disease Behavioural Neurology |
| author_facet |
D. H. Jacobs S. J. Huber |
| author_sort |
D. H. Jacobs |
| title |
The Role of the Caudate in Nonmotor Behaviors in Huntington’s Disease |
| title_short |
The Role of the Caudate in Nonmotor Behaviors in Huntington’s Disease |
| title_full |
The Role of the Caudate in Nonmotor Behaviors in Huntington’s Disease |
| title_fullStr |
The Role of the Caudate in Nonmotor Behaviors in Huntington’s Disease |
| title_full_unstemmed |
The Role of the Caudate in Nonmotor Behaviors in Huntington’s Disease |
| title_sort |
role of the caudate in nonmotor behaviors in huntington’s disease |
| publisher |
Hindawi Limited |
| series |
Behavioural Neurology |
| issn |
0953-4180 1875-8584 |
| publishDate |
1992-01-01 |
| description |
Neuropsychologic data suggest an important role for the caudate nucleus (CN) in behavioral impairments in Huntington's disease (HD). These include abnormalities in executive function, egocentric visuospatial representations, communication, and retrieval of declarative memories, changes in personality, and psychiatric disturbances. Animal paradigms of CN lesions support a role for the CN in some of these behaviors. Current theories of basal ganglia function add explanatory value to the role of the CN in these behaviors. A disconnection of the caudate from limbic structures, including the amygdala may account for many nonmotor behaviors observed in HD. |
| url |
http://dx.doi.org/10.3233/BEN-1992-5402 |
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