Experimental study for treatment of low-intensity laser on neuropathic pain in diabetic rats
Objective: To systematically identify the therapeutic effects of low-intensity laser with 830 nm on diabetic neuropathic pain. Methods: Thirty male SPF Wistar rats were equally assigned to the blank control (Control), diabetic neuropathic pain (DNP) and diabetic neuropathic pain exposed to the la...
Main Authors: | , |
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Format: | Article |
Language: | English |
Published: |
Editorial Board of Journal of Hainan Medical University
2019-09-01
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Series: | Journal of Hainan Medical University |
Subjects: | |
Online Access: | http://www.hnykdxxb.com/PDF/201918/2.pdf |
Summary: | Objective: To systematically identify the therapeutic effects of low-intensity laser with 830
nm on diabetic neuropathic pain. Methods: Thirty male SPF Wistar rats were equally assigned
to the blank control (Control), diabetic neuropathic pain (DNP) and diabetic neuropathic
pain exposed to the laser treatment (DNP+Laser) groups. The rats in the DNP group and
DNP+Laser group were subjected to intraperitoneal injection with streptozotocin (STZ) to
establish the diabetic animal model. The rats in the DNP+Laser group were exposed to laser
stimulation (700 Hz, 60 mW) with 3 sessions per day and 50 s per session for overall 8 weeks.
The paw mechanical pain threshold levels and thermal pain threshold levels were measured at 0,
2, 4, 6 and 8 weeks post the STZ administration, and the motor nerve conduction velocity and
sensory nerve conduction velocity were also determined. Results: The rats in the DNP+EMF
group showed significantly higher paw mechanical pain threshold levels and thermal
pain threshold levels than the rats in the DNP group (P<0.05). Moreover, the motor nerve
conduction velocity and sensory nerve conduction velocity in the DNP+Laser group were also
significantly higher than those in the DNP group (P<0.05). Conclusion: Low-intensity laser
stimulation displayed positive effects on the attenuation of the progression of neuropathic pain
in diabetic rats, implying that low-intensity laser treatment has the potential to be an effective
biophysical approach for diabetic neuropathic pain in clinics. |
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ISSN: | 1007-1237 1007-1237 |