CLINICAL AND EXPERIMENTAL EVIDENCES OF EFFECTIVE MODE OF AEROSOL LAPAROSCOPIC INTRAPERITONEAL CHEMOTHERAPY

• Main Authors: S. F. Bagnenko, A. A. Zakharenko, A. S. Nakhta, M. A. Belyaev, A. A. Trushin, O. A. Ten, Yu. P. Koval’Chuk, D. A. Zaitsev, M. V. Yakovleva
• Format: Article
• Language: Russian
• Published: Pavlov First Saint Petersburg State Medical University 2017-04-01
• Series: Вестник хирургии имени И.И. Грекова
• Subjects: peritoneal carcinomatosis; aerosol chemotherapy; laparoscopy
• Online Access: https://www.vestnik-grekova.ru/jour/article/view/328
• ISSN: 0042-4625

OBJECIVE. The authors would like to design an original device for aerosol laparoscopic chemotherapy and propose the most effective and safe mode. MATERIALS AND METHODS. The experimental and clinical studies were carried out and included 6 series. Male rabbits (n=71) were used for experimental part and the method was applied on 4 patients in clinical part. RESULTS. The original device and the effective mode of its application were developed for aerosol laparoscopic chemotherapy. The supposed method of chemotherapy appeared to be more effective than the standard method. There weren’t noted any complications or side effects. The method proved its safety. CONCLUSIONS. The aerosol laparoscopic intraperitoneal chemotherapy using the proposed regime is the effective and safe method of peritoneal carcinomatosis treatment.