Ferroptosis Mechanisms Involved in Hippocampal-Related Diseases
Ferroptosis is a newly recognized type of cell death that is different from traditional forms of cell death, such as apoptosis, autophagy, and necrosis. It is caused by the accumulation of intracellular iron, promoting lipid peroxidation and leading to cell death. Iron is essential as a redox metal...
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doaj-470333a5ffa147368b8297b6dd2ffcca2021-09-26T00:23:35ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-09-01229902990210.3390/ijms22189902Ferroptosis Mechanisms Involved in Hippocampal-Related DiseasesXintong Wang0Zixu Wang1Jing Cao2Yulan Dong3Yaoxing Chen4Neurobiology Laboratory, College of Veterinary Medicine, China Agricultural University, Haidian, Beijing 100193, ChinaNeurobiology Laboratory, College of Veterinary Medicine, China Agricultural University, Haidian, Beijing 100193, ChinaNeurobiology Laboratory, College of Veterinary Medicine, China Agricultural University, Haidian, Beijing 100193, ChinaNeurobiology Laboratory, College of Veterinary Medicine, China Agricultural University, Haidian, Beijing 100193, ChinaNeurobiology Laboratory, College of Veterinary Medicine, China Agricultural University, Haidian, Beijing 100193, ChinaFerroptosis is a newly recognized type of cell death that is different from traditional forms of cell death, such as apoptosis, autophagy, and necrosis. It is caused by the accumulation of intracellular iron, promoting lipid peroxidation and leading to cell death. Iron is essential as a redox metal in several physiological functions. The brain is one of the organs known to be affected by iron homeostatic balance disruption. An increased concentration of iron in the central nervous system has been associated with oxidative stress, lipid peroxidation of proteins, and cell death. The hippocampus is an important brain region for learning, memory, and emotional responses, and is also a sensitive part of the brain to the dysfunctional homeostasis of transition metals. Damage of hippocampal structure and function are intimately involved in the pathogenic mechanisms underlying neurodegenerative diseases. Currently, ferroptosis is playing an increasingly important role in treatment areas of central nervous system diseases. Thus, we provide an overview of ferroptosis regulatory mechanisms, such as lipid metabolism, glutathione metabolism, and iron metabolism in this review. We also highlight the role of ferroptosis in hippocampal-related diseases and investigate a theoretical basis for further research on the role of ferroptosis in nervous system disease treatment.https://www.mdpi.com/1422-0067/22/18/9902hippocampusferroptosisneurological diseasesironlipid peroxide |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Xintong Wang Zixu Wang Jing Cao Yulan Dong Yaoxing Chen |
spellingShingle |
Xintong Wang Zixu Wang Jing Cao Yulan Dong Yaoxing Chen Ferroptosis Mechanisms Involved in Hippocampal-Related Diseases International Journal of Molecular Sciences hippocampus ferroptosis neurological diseases iron lipid peroxide |
author_facet |
Xintong Wang Zixu Wang Jing Cao Yulan Dong Yaoxing Chen |
author_sort |
Xintong Wang |
title |
Ferroptosis Mechanisms Involved in Hippocampal-Related Diseases |
title_short |
Ferroptosis Mechanisms Involved in Hippocampal-Related Diseases |
title_full |
Ferroptosis Mechanisms Involved in Hippocampal-Related Diseases |
title_fullStr |
Ferroptosis Mechanisms Involved in Hippocampal-Related Diseases |
title_full_unstemmed |
Ferroptosis Mechanisms Involved in Hippocampal-Related Diseases |
title_sort |
ferroptosis mechanisms involved in hippocampal-related diseases |
publisher |
MDPI AG |
series |
International Journal of Molecular Sciences |
issn |
1661-6596 1422-0067 |
publishDate |
2021-09-01 |
description |
Ferroptosis is a newly recognized type of cell death that is different from traditional forms of cell death, such as apoptosis, autophagy, and necrosis. It is caused by the accumulation of intracellular iron, promoting lipid peroxidation and leading to cell death. Iron is essential as a redox metal in several physiological functions. The brain is one of the organs known to be affected by iron homeostatic balance disruption. An increased concentration of iron in the central nervous system has been associated with oxidative stress, lipid peroxidation of proteins, and cell death. The hippocampus is an important brain region for learning, memory, and emotional responses, and is also a sensitive part of the brain to the dysfunctional homeostasis of transition metals. Damage of hippocampal structure and function are intimately involved in the pathogenic mechanisms underlying neurodegenerative diseases. Currently, ferroptosis is playing an increasingly important role in treatment areas of central nervous system diseases. Thus, we provide an overview of ferroptosis regulatory mechanisms, such as lipid metabolism, glutathione metabolism, and iron metabolism in this review. We also highlight the role of ferroptosis in hippocampal-related diseases and investigate a theoretical basis for further research on the role of ferroptosis in nervous system disease treatment. |
topic |
hippocampus ferroptosis neurological diseases iron lipid peroxide |
url |
https://www.mdpi.com/1422-0067/22/18/9902 |
work_keys_str_mv |
AT xintongwang ferroptosismechanismsinvolvedinhippocampalrelateddiseases AT zixuwang ferroptosismechanismsinvolvedinhippocampalrelateddiseases AT jingcao ferroptosismechanismsinvolvedinhippocampalrelateddiseases AT yulandong ferroptosismechanismsinvolvedinhippocampalrelateddiseases AT yaoxingchen ferroptosismechanismsinvolvedinhippocampalrelateddiseases |
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