Hydrophilic Surface Functionalization of Electrospun Nanofibrous Scaffolds in Tissue Engineering
Electrospun polymer nanofibers have received much attention in tissue engineering due to their valuable properties such as biocompatibility, biodegradation ability, appropriate mechanical properties, and, most importantly, fibrous structure, which resembles the morphology of extracellular matrix (EC...
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doaj-4703d54cf69343c9af516efadcb9fd842020-11-25T04:06:45ZengMDPI AGPolymers2073-43602020-11-01122636263610.3390/polym12112636Hydrophilic Surface Functionalization of Electrospun Nanofibrous Scaffolds in Tissue EngineeringBeata Niemczyk-Soczynska0Arkadiusz Gradys1Pawel Sajkiewicz2Institute of Fundamental Technological Research, Lab. Polymers & Biomaterials, Polish Academy of Sciences Pawinskiego 5b St., 02-106 Warsaw, PolandInstitute of Fundamental Technological Research, Lab. Polymers & Biomaterials, Polish Academy of Sciences Pawinskiego 5b St., 02-106 Warsaw, PolandInstitute of Fundamental Technological Research, Lab. Polymers & Biomaterials, Polish Academy of Sciences Pawinskiego 5b St., 02-106 Warsaw, PolandElectrospun polymer nanofibers have received much attention in tissue engineering due to their valuable properties such as biocompatibility, biodegradation ability, appropriate mechanical properties, and, most importantly, fibrous structure, which resembles the morphology of extracellular matrix (ECM) proteins. However, they are usually hydrophobic and suffer from a lack of bioactive molecules, which provide good cell adhesion to the scaffold surface. Post-electrospinning surface functionalization allows overcoming these limitations through polar groups covalent incorporation to the fibers surface, with subsequent functionalization with biologically active molecules or direct deposition of the biomolecule solution. Hydrophilic surface functionalization methods are classified into chemical approaches, including wet chemical functionalization and covalent grafting, a physiochemical approach with the use of a plasma treatment, and a physical approach that might be divided into physical adsorption and layer-by-layer assembly. This review discusses the state-of-the-art of hydrophilic surface functionalization strategies of electrospun nanofibers for tissue engineering applications. We highlighted the major advantages and drawbacks of each method, at the same time, pointing out future perspectives and solutions in the hydrophilic functionalization strategies.https://www.mdpi.com/2073-4360/12/11/2636surface functionalizationelectrospinningpolymersnanofiberimmobilizationtissue engineering |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Beata Niemczyk-Soczynska Arkadiusz Gradys Pawel Sajkiewicz |
spellingShingle |
Beata Niemczyk-Soczynska Arkadiusz Gradys Pawel Sajkiewicz Hydrophilic Surface Functionalization of Electrospun Nanofibrous Scaffolds in Tissue Engineering Polymers surface functionalization electrospinning polymers nanofiber immobilization tissue engineering |
author_facet |
Beata Niemczyk-Soczynska Arkadiusz Gradys Pawel Sajkiewicz |
author_sort |
Beata Niemczyk-Soczynska |
title |
Hydrophilic Surface Functionalization of Electrospun Nanofibrous Scaffolds in Tissue Engineering |
title_short |
Hydrophilic Surface Functionalization of Electrospun Nanofibrous Scaffolds in Tissue Engineering |
title_full |
Hydrophilic Surface Functionalization of Electrospun Nanofibrous Scaffolds in Tissue Engineering |
title_fullStr |
Hydrophilic Surface Functionalization of Electrospun Nanofibrous Scaffolds in Tissue Engineering |
title_full_unstemmed |
Hydrophilic Surface Functionalization of Electrospun Nanofibrous Scaffolds in Tissue Engineering |
title_sort |
hydrophilic surface functionalization of electrospun nanofibrous scaffolds in tissue engineering |
publisher |
MDPI AG |
series |
Polymers |
issn |
2073-4360 |
publishDate |
2020-11-01 |
description |
Electrospun polymer nanofibers have received much attention in tissue engineering due to their valuable properties such as biocompatibility, biodegradation ability, appropriate mechanical properties, and, most importantly, fibrous structure, which resembles the morphology of extracellular matrix (ECM) proteins. However, they are usually hydrophobic and suffer from a lack of bioactive molecules, which provide good cell adhesion to the scaffold surface. Post-electrospinning surface functionalization allows overcoming these limitations through polar groups covalent incorporation to the fibers surface, with subsequent functionalization with biologically active molecules or direct deposition of the biomolecule solution. Hydrophilic surface functionalization methods are classified into chemical approaches, including wet chemical functionalization and covalent grafting, a physiochemical approach with the use of a plasma treatment, and a physical approach that might be divided into physical adsorption and layer-by-layer assembly. This review discusses the state-of-the-art of hydrophilic surface functionalization strategies of electrospun nanofibers for tissue engineering applications. We highlighted the major advantages and drawbacks of each method, at the same time, pointing out future perspectives and solutions in the hydrophilic functionalization strategies. |
topic |
surface functionalization electrospinning polymers nanofiber immobilization tissue engineering |
url |
https://www.mdpi.com/2073-4360/12/11/2636 |
work_keys_str_mv |
AT beataniemczyksoczynska hydrophilicsurfacefunctionalizationofelectrospunnanofibrousscaffoldsintissueengineering AT arkadiuszgradys hydrophilicsurfacefunctionalizationofelectrospunnanofibrousscaffoldsintissueengineering AT pawelsajkiewicz hydrophilicsurfacefunctionalizationofelectrospunnanofibrousscaffoldsintissueengineering |
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