The mechanism of a high-affinity allosteric inhibitor of the serotonin transporter

The serotonin transporter (SERT) terminates serotonin signaling and its activity is modulated by antidepressants. Here authors reveal the mechanistic details underlying the coupling between the two binding sites in SERT and a high-affinity ligand for the allosteric site.

Bibliographic Details
Main Authors:	Per Plenge, Ara M. Abramyan, Gunnar Sørensen, Arne Mørk, Pia Weikop, Ulrik Gether, Benny Bang-Andersen, Lei Shi, Claus J. Loland
Format:	Article
Language:	English
Published:	Nature Publishing Group 2020-03-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-020-15292-y

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spelling	doaj-4706c23f56b542ffad3d502b3f12fe7e2021-05-11T07:58:33ZengNature Publishing GroupNature Communications2041-17232020-03-0111111210.1038/s41467-020-15292-yThe mechanism of a high-affinity allosteric inhibitor of the serotonin transporterPer Plenge0Ara M. Abramyan1Gunnar Sørensen2Arne Mørk3Pia Weikop4Ulrik Gether5Benny Bang-Andersen6Lei Shi7Claus J. Loland8Laboratory for Membrane Protein Dynamics. Department of Neuroscience, Faculty of Health and Medical Sciences, University of CopenhagenComputational Chemistry and Molecular Biophysics Unit, Molecular Targets and Medications Discovery Branch, National Institute on Drug Abuse—Intramural Research Program, National Institutes of HealthLundbeck Research, H. Lundbeck A/SLundbeck Research, H. Lundbeck A/SLaboratory of Neuropsychiatry, Psychiatric Centre Copenhagen, University of CopenhagenDepartment of Neuroscience, Faculty of Health and Medical Sciences, University of CopenhagenLundbeck Research, H. Lundbeck A/SComputational Chemistry and Molecular Biophysics Unit, Molecular Targets and Medications Discovery Branch, National Institute on Drug Abuse—Intramural Research Program, National Institutes of HealthLaboratory for Membrane Protein Dynamics. Department of Neuroscience, Faculty of Health and Medical Sciences, University of CopenhagenThe serotonin transporter (SERT) terminates serotonin signaling and its activity is modulated by antidepressants. Here authors reveal the mechanistic details underlying the coupling between the two binding sites in SERT and a high-affinity ligand for the allosteric site.https://doi.org/10.1038/s41467-020-15292-y
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Per Plenge Ara M. Abramyan Gunnar Sørensen Arne Mørk Pia Weikop Ulrik Gether Benny Bang-Andersen Lei Shi Claus J. Loland
spellingShingle	Per Plenge Ara M. Abramyan Gunnar Sørensen Arne Mørk Pia Weikop Ulrik Gether Benny Bang-Andersen Lei Shi Claus J. Loland The mechanism of a high-affinity allosteric inhibitor of the serotonin transporter Nature Communications
author_facet	Per Plenge Ara M. Abramyan Gunnar Sørensen Arne Mørk Pia Weikop Ulrik Gether Benny Bang-Andersen Lei Shi Claus J. Loland
author_sort	Per Plenge
title	The mechanism of a high-affinity allosteric inhibitor of the serotonin transporter
title_short	The mechanism of a high-affinity allosteric inhibitor of the serotonin transporter
title_full	The mechanism of a high-affinity allosteric inhibitor of the serotonin transporter
title_fullStr	The mechanism of a high-affinity allosteric inhibitor of the serotonin transporter
title_full_unstemmed	The mechanism of a high-affinity allosteric inhibitor of the serotonin transporter
title_sort	mechanism of a high-affinity allosteric inhibitor of the serotonin transporter
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2020-03-01
description	The serotonin transporter (SERT) terminates serotonin signaling and its activity is modulated by antidepressants. Here authors reveal the mechanistic details underlying the coupling between the two binding sites in SERT and a high-affinity ligand for the allosteric site.
url	https://doi.org/10.1038/s41467-020-15292-y
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The mechanism of a high-affinity allosteric inhibitor of the serotonin transporter

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