Quercetin Inhibits Pacemaker Potentials via Nitric Oxide/cGMP-Dependent Activation and TRPM7/ANO1 Channels in Cultured Interstitial Cells of Cajal from Mouse Small Intestine

Quercetin Inhibits Pacemaker Potentials via Nitric Oxide/cGMP-Dependent Activation and TRPM7/ANO1 Channels in Cultured Interstitial Cells of Cajal from Mouse Small Intestine

Background: Quercetin regulates gastrointestinal (GI) motor activity but the molecular mechanism involved has not been determined. The authors investigated the effects of quercetin, a flavonoid present in various foods, on the pacemaker activities of interstitial cells of Cajal (ICCs) in murine smal...

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Bibliographic Details
Main Authors: Huijin Gim, Joo Hyun Nam, Soojin Lee, Ji Hwan Shim, Hyun Jung Kim, Ki-Tae Ha, Byung Joo Kim
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2015-04-01
Series:Cellular Physiology and Biochemistry
Subjects:
Interstitial Cells of Cajal
Quercetin
Gastrointestinal tract
TRPM7 channel
ANO1
Online Access:http://www.karger.com/Article/FullText/374043

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