The NRAMP1 polymorphism as a risk factor for tuberculous spondylitis
In the present study, we analysed the association between the incidence of tuberculous spondylitis with the Natural Resistance Associated Macrophage Protein 1 (NRAMP1, also known as Solute Carrier Family 11a member1) polymorphism by studying the genetic segregation of this polymorphism and the inci...
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Online Access: | http://www.morthoj.org/2013/v7n1/tuberculous-spondylitis.pdf |
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doaj-4710af3f402c45fc9ab973c0e9ceac942021-05-02T14:54:33ZengMalaysian Orthopaedic AssociationMalaysian Orthopaedic Journal1985-25332013-03-0171252910.5704/MOJ.1303.012The NRAMP1 polymorphism as a risk factor for tuberculous spondylitisBambang Tiksnadi0Herry Herman1PhDPhDIn the present study, we analysed the association between the incidence of tuberculous spondylitis with the Natural Resistance Associated Macrophage Protein 1 (NRAMP1, also known as Solute Carrier Family 11a member1) polymorphism by studying the genetic segregation of this polymorphism and the incidence of the disease among members of the West Javanese population undergoing surgery for tuberculous spondylitis at our institution. We compared the distribution of NRAMP1 polymorphism at two specific sites, namely D543N, and 3’UTR, among subjects with pulmonary tuberculosis and tuberculous spondylitis. We found no significant differences in distribution of polymorphism between the two groups, or between pulmonary tuberculosis and tuberculous spondylitis compared to healthy subjects. However, a pattern emerged in that polymorphisms at the two sites seemed to be protective against development of tuberculous spondylitis in our study population. We concluded that in the West Javanese population, there is no association between NRAMP1 polymorphism with the propensity for development of pulmonary tuberculosis or tuberculous spondylitis. In fact, NRAMP1 may provide protection against the development of tuberculous spondylitis.http://www.morthoj.org/2013/v7n1/tuberculous-spondylitis.pdftuberculous spondylitisNRAMP1polymorphism |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Bambang Tiksnadi Herry Herman |
spellingShingle |
Bambang Tiksnadi Herry Herman The NRAMP1 polymorphism as a risk factor for tuberculous spondylitis Malaysian Orthopaedic Journal tuberculous spondylitis NRAMP1 polymorphism |
author_facet |
Bambang Tiksnadi Herry Herman |
author_sort |
Bambang Tiksnadi |
title |
The NRAMP1 polymorphism as a risk factor for tuberculous spondylitis |
title_short |
The NRAMP1 polymorphism as a risk factor for tuberculous spondylitis |
title_full |
The NRAMP1 polymorphism as a risk factor for tuberculous spondylitis |
title_fullStr |
The NRAMP1 polymorphism as a risk factor for tuberculous spondylitis |
title_full_unstemmed |
The NRAMP1 polymorphism as a risk factor for tuberculous spondylitis |
title_sort |
nramp1 polymorphism as a risk factor for tuberculous spondylitis |
publisher |
Malaysian Orthopaedic Association |
series |
Malaysian Orthopaedic Journal |
issn |
1985-2533 |
publishDate |
2013-03-01 |
description |
In the present study, we analysed the association between the
incidence of tuberculous spondylitis with the Natural Resistance Associated Macrophage Protein 1 (NRAMP1, also known as Solute Carrier Family 11a member1) polymorphism by studying the genetic segregation of this polymorphism and the incidence of the disease among members of the West Javanese population undergoing
surgery for tuberculous spondylitis at our institution. We compared the distribution of NRAMP1 polymorphism at two specific sites, namely D543N, and 3’UTR, among subjects with pulmonary tuberculosis and tuberculous spondylitis. We found no significant differences in distribution of polymorphism between the two groups, or between pulmonary tuberculosis and tuberculous spondylitis
compared to healthy subjects. However, a pattern emerged in
that polymorphisms at the two sites seemed to be protective
against development of tuberculous spondylitis in our study
population. We concluded that in the West Javanese population, there is no association between NRAMP1 polymorphism with the propensity for development of pulmonary tuberculosis or tuberculous spondylitis. In fact, NRAMP1 may provide protection against the development of tuberculous spondylitis. |
topic |
tuberculous spondylitis NRAMP1 polymorphism |
url |
http://www.morthoj.org/2013/v7n1/tuberculous-spondylitis.pdf |
work_keys_str_mv |
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1721490478520598528 |