Surfactant Administration in Preterm Neonates Using Laryngeal Mask Airway: A Randomized Clinical Trial
In this study, we aimed to compare the efficacy of laryngeal mask airway (LMA) versus endotracheal tube in the early rescue surfactant administration in premature neonates with respiratory distress syndrome (RDS). This randomized, clinical trial evaluated 60 premature neonates with RDS. Numbered en...
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Tehran University of Medical Sciences
2019-11-01
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doaj-4711552661594d42842c5fe648e3ffef2020-11-25T02:36:00ZengTehran University of Medical SciencesActa Medica Iranica0044-60251735-96942019-11-0157610.18502/acta.v57i6.1877Surfactant Administration in Preterm Neonates Using Laryngeal Mask Airway: A Randomized Clinical TrialElaheh Amini0Mahdi Sheikh1Mamak Shariat2Hosein Dalili3Negin Azadi4Sajjad Nourollahi5Maternal, Fetal and Neonatal Research Center, Tehran University of Medical Sciences, Tehran, Iran.Maternal, Fetal and Neonatal Research Center, Tehran University of Medical Sciences, Tehran, Iran.Maternal, Fetal and Neonatal Research Center, Tehran University of Medical Sciences, Tehran, Iran.Breastfeeding Research Center, Tehran University of Medical Sciences, Tehran, Iran.Maternal, Fetal and Neonatal Research Center, Tehran University of Medical Sciences, Tehran, Iran.Breastfeeding Research Center, Tehran University of Medical Sciences, Tehran, Iran. In this study, we aimed to compare the efficacy of laryngeal mask airway (LMA) versus endotracheal tube in the early rescue surfactant administration in premature neonates with respiratory distress syndrome (RDS). This randomized, clinical trial evaluated 60 premature neonates with RDS. Numbered envelopes randomly assigned 30 neonates to the intervention group to receive 2.5 ml/kg/dose surfactant (Curosurf) via LMA and 30 to the control group to receive 2.5 ml/kg/dose surfactant via an endotracheal tube using the INSURE technique, exclusively during the first two hours of life. There were no differences in the requirement for mechanical ventilation (23.3% vs. 20%, P=0.75), requirement for second dose surfactant (13.3% vs. 6.7%, P=0.67), bronchopulmonary dysplasia (13.3% vs. 6.7%, P=0.67), pneumothorax (6.7% vs. 0%, P=0.49), and intraventricular hemorrhage (10% vs. 10%, P=1) between neonates who received surfactant via LMA versus those who received surfactant via endotracheal tube. LMA seems to be an effective and less invasive alternative to endotracheal intubation for surfactant delivery in premature neonates with RDS. https://acta.tums.ac.ir/index.php/acta/article/view/7614InfantsIntubationLMAPrematurePretermSurfactant |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Elaheh Amini Mahdi Sheikh Mamak Shariat Hosein Dalili Negin Azadi Sajjad Nourollahi |
spellingShingle |
Elaheh Amini Mahdi Sheikh Mamak Shariat Hosein Dalili Negin Azadi Sajjad Nourollahi Surfactant Administration in Preterm Neonates Using Laryngeal Mask Airway: A Randomized Clinical Trial Acta Medica Iranica Infants Intubation LMA Premature Preterm Surfactant |
author_facet |
Elaheh Amini Mahdi Sheikh Mamak Shariat Hosein Dalili Negin Azadi Sajjad Nourollahi |
author_sort |
Elaheh Amini |
title |
Surfactant Administration in Preterm Neonates Using Laryngeal Mask Airway: A Randomized Clinical Trial |
title_short |
Surfactant Administration in Preterm Neonates Using Laryngeal Mask Airway: A Randomized Clinical Trial |
title_full |
Surfactant Administration in Preterm Neonates Using Laryngeal Mask Airway: A Randomized Clinical Trial |
title_fullStr |
Surfactant Administration in Preterm Neonates Using Laryngeal Mask Airway: A Randomized Clinical Trial |
title_full_unstemmed |
Surfactant Administration in Preterm Neonates Using Laryngeal Mask Airway: A Randomized Clinical Trial |
title_sort |
surfactant administration in preterm neonates using laryngeal mask airway: a randomized clinical trial |
publisher |
Tehran University of Medical Sciences |
series |
Acta Medica Iranica |
issn |
0044-6025 1735-9694 |
publishDate |
2019-11-01 |
description |
In this study, we aimed to compare the efficacy of laryngeal mask airway (LMA) versus endotracheal tube in the early rescue surfactant administration in premature neonates with respiratory distress syndrome (RDS). This randomized, clinical trial evaluated 60 premature neonates with RDS. Numbered envelopes randomly assigned 30 neonates to the intervention group to receive 2.5 ml/kg/dose surfactant (Curosurf) via LMA and 30 to the control group to receive 2.5 ml/kg/dose surfactant via an endotracheal tube using the INSURE technique, exclusively during the first two hours of life. There were no differences in the requirement for mechanical ventilation (23.3% vs. 20%, P=0.75), requirement for second dose surfactant (13.3% vs. 6.7%, P=0.67), bronchopulmonary dysplasia (13.3% vs. 6.7%, P=0.67), pneumothorax (6.7% vs. 0%, P=0.49), and intraventricular hemorrhage (10% vs. 10%, P=1) between neonates who received surfactant via LMA versus those who received surfactant via endotracheal tube. LMA seems to be an effective and less invasive alternative to endotracheal intubation for surfactant delivery in premature neonates with RDS.
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topic |
Infants Intubation LMA Premature Preterm Surfactant |
url |
https://acta.tums.ac.ir/index.php/acta/article/view/7614 |
work_keys_str_mv |
AT elahehamini surfactantadministrationinpretermneonatesusinglaryngealmaskairwayarandomizedclinicaltrial AT mahdisheikh surfactantadministrationinpretermneonatesusinglaryngealmaskairwayarandomizedclinicaltrial AT mamakshariat surfactantadministrationinpretermneonatesusinglaryngealmaskairwayarandomizedclinicaltrial AT hoseindalili surfactantadministrationinpretermneonatesusinglaryngealmaskairwayarandomizedclinicaltrial AT neginazadi surfactantadministrationinpretermneonatesusinglaryngealmaskairwayarandomizedclinicaltrial AT sajjadnourollahi surfactantadministrationinpretermneonatesusinglaryngealmaskairwayarandomizedclinicaltrial |
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