Anti-inflammatory and antifatigue effect of Korean Red Ginseng in patients with nonalcoholic fatty liver disease
Background: Korean Red Ginseng (KRG) is a well-known natural product with anticarcinogenic and antioxidant effects. We evaluated the antifatigue effect of KRG in patients with nonalcoholic fatty liver disease (NAFLD). Methods: Eighty patients with NAFLD were prospectively randomized to receive 3 wk...
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doaj-47157b4528734a2c9630ca44a0be5b8a2020-11-24T20:59:53ZengElsevierJournal of Ginseng Research1226-84532016-07-0140320321010.1016/j.jgr.2015.07.006Anti-inflammatory and antifatigue effect of Korean Red Ginseng in patients with nonalcoholic fatty liver diseaseMeegun Hong0Yoon Hyeong Lee1Seungwoo Kim2Ki Tae Suk3Chang Seok Bang4Jai Hoon Yoon5Gwang Ho Baik6Dong Joon Kim7Myong Jo Kim8Department of Internal Medicine, Hallym University College of Medicine, Chuncheon, KoreaDepartment of Internal Medicine, Hallym University College of Medicine, Chuncheon, KoreaDepartment of Biomedical Science, Hallym University College of Medicine, Chuncheon, KoreaDepartment of Internal Medicine, Hallym University College of Medicine, Chuncheon, KoreaDepartment of Internal Medicine, Hallym University College of Medicine, Chuncheon, KoreaDepartment of Internal Medicine, Hallym University College of Medicine, Chuncheon, KoreaDepartment of Internal Medicine, Hallym University College of Medicine, Chuncheon, KoreaDepartment of Internal Medicine, Hallym University College of Medicine, Chuncheon, KoreaCollege of Agriculture and Life Science, Kangwon National University, Chuncheon, KoreaBackground: Korean Red Ginseng (KRG) is a well-known natural product with anticarcinogenic and antioxidant effects. We evaluated the antifatigue effect of KRG in patients with nonalcoholic fatty liver disease (NAFLD). Methods: Eighty patients with NAFLD were prospectively randomized to receive 3 wk of KRG or placebo in addition to counseling on healthy eating and regular exercise. Liver function test, proinflammatory cytokines, adiponectin, antioxidant activity, and fatigue score were measured and compared according to the body mass index between the KRG and placebo groups. Results: The liver function tests were significantly improved after 3 wk of treatment in both groups. The mean levels (at baseline and after treatment) of tumor necrosis factor-α were 108.0 pg/mL ± 54.8 pg/mL and 92.7 pg/mL ± 39.0 pg/mL (p = 0.018) in the KRG group and 123.1 pg/mL ± 42.1 pg/mL and 127.5 pg/mL ± 62.2 pg/mL (p = 0.694) in the placebo group, respectively. There was a significant difference in change of adiponectin levels between the KRG (7,751.2 pg/mL ± 3,108.1 pg/mL and 8,197.3 pg/mL ± 2,714.5 pg/mL) and placebo groups (7,711.6 pg/mL ± 3,041.3 pg/mL and 7,286.1 pg/mL ± 5,188.7 pg/mL, p = 0.027). In patients with overweight, the fatigue score was significantly decreased in the KRG group (35.0 ± 13.2 and 24.5 ± 8.9, p = 0.019). Conclusion: Our results show that KRG might be effective in reducing proinflammatory cytokine and fatigue in overweight patients with NAFLD, in addition to improvements in adiponectin levels.http://www.sciencedirect.com/science/article/pii/S1226845315000731adiponectinchronic hepatitisfatty liverPanax ginseng |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Meegun Hong Yoon Hyeong Lee Seungwoo Kim Ki Tae Suk Chang Seok Bang Jai Hoon Yoon Gwang Ho Baik Dong Joon Kim Myong Jo Kim |
spellingShingle |
Meegun Hong Yoon Hyeong Lee Seungwoo Kim Ki Tae Suk Chang Seok Bang Jai Hoon Yoon Gwang Ho Baik Dong Joon Kim Myong Jo Kim Anti-inflammatory and antifatigue effect of Korean Red Ginseng in patients with nonalcoholic fatty liver disease Journal of Ginseng Research adiponectin chronic hepatitis fatty liver Panax ginseng |
author_facet |
Meegun Hong Yoon Hyeong Lee Seungwoo Kim Ki Tae Suk Chang Seok Bang Jai Hoon Yoon Gwang Ho Baik Dong Joon Kim Myong Jo Kim |
author_sort |
Meegun Hong |
title |
Anti-inflammatory and antifatigue effect of Korean Red Ginseng in patients with nonalcoholic fatty liver disease |
title_short |
Anti-inflammatory and antifatigue effect of Korean Red Ginseng in patients with nonalcoholic fatty liver disease |
title_full |
Anti-inflammatory and antifatigue effect of Korean Red Ginseng in patients with nonalcoholic fatty liver disease |
title_fullStr |
Anti-inflammatory and antifatigue effect of Korean Red Ginseng in patients with nonalcoholic fatty liver disease |
title_full_unstemmed |
Anti-inflammatory and antifatigue effect of Korean Red Ginseng in patients with nonalcoholic fatty liver disease |
title_sort |
anti-inflammatory and antifatigue effect of korean red ginseng in patients with nonalcoholic fatty liver disease |
publisher |
Elsevier |
series |
Journal of Ginseng Research |
issn |
1226-8453 |
publishDate |
2016-07-01 |
description |
Background: Korean Red Ginseng (KRG) is a well-known natural product with anticarcinogenic and antioxidant effects. We evaluated the antifatigue effect of KRG in patients with nonalcoholic fatty liver disease (NAFLD).
Methods: Eighty patients with NAFLD were prospectively randomized to receive 3 wk of KRG or placebo in addition to counseling on healthy eating and regular exercise. Liver function test, proinflammatory cytokines, adiponectin, antioxidant activity, and fatigue score were measured and compared according to the body mass index between the KRG and placebo groups.
Results: The liver function tests were significantly improved after 3 wk of treatment in both groups. The mean levels (at baseline and after treatment) of tumor necrosis factor-α were 108.0 pg/mL ± 54.8 pg/mL and 92.7 pg/mL ± 39.0 pg/mL (p = 0.018) in the KRG group and 123.1 pg/mL ± 42.1 pg/mL and 127.5 pg/mL ± 62.2 pg/mL (p = 0.694) in the placebo group, respectively. There was a significant difference in change of adiponectin levels between the KRG (7,751.2 pg/mL ± 3,108.1 pg/mL and 8,197.3 pg/mL ± 2,714.5 pg/mL) and placebo groups (7,711.6 pg/mL ± 3,041.3 pg/mL and 7,286.1 pg/mL ± 5,188.7 pg/mL, p = 0.027). In patients with overweight, the fatigue score was significantly decreased in the KRG group (35.0 ± 13.2 and 24.5 ± 8.9, p = 0.019).
Conclusion: Our results show that KRG might be effective in reducing proinflammatory cytokine and fatigue in overweight patients with NAFLD, in addition to improvements in adiponectin levels. |
topic |
adiponectin chronic hepatitis fatty liver Panax ginseng |
url |
http://www.sciencedirect.com/science/article/pii/S1226845315000731 |
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