PKCα Inhibition as a Strategy to Sensitize Neuroblastoma Stem Cells to Etoposide by Stimulating Ferroptosis

PKCα Inhibition as a Strategy to Sensitize Neuroblastoma Stem Cells to Etoposide by Stimulating Ferroptosis

Cancer stem cells (CSCs) are a limited cell population inside a tumor bulk characterized by high levels of glutathione (GSH), the most important antioxidant thiol of which cysteine is the limiting amino acid for GSH biosynthesis. In fact, CSCs over-express xCT, a cystine transporter stabilized on ce...

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Bibliographic Details
Main Authors: Lorenzo Monteleone, Andrea Speciale, Giulia Elda Valenti, Nicola Traverso, Silvia Ravera, Ombretta Garbarino, Riccardo Leardi, Emanuele Farinini, Antonella Roveri, Fulvio Ursini, Claudia Cantoni, Maria Adelaide Pronzato, Umberto Maria Marinari, Barbara Marengo, Cinzia Domenicotti
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:Antioxidants
Subjects:
cancer stem cells
chemoresistance
glutathione
lipid peroxidation
ZEB-1
GPX4
Online Access:https://www.mdpi.com/2076-3921/10/5/691

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