PKCα Inhibition as a Strategy to Sensitize Neuroblastoma Stem Cells to Etoposide by Stimulating Ferroptosis
Cancer stem cells (CSCs) are a limited cell population inside a tumor bulk characterized by high levels of glutathione (GSH), the most important antioxidant thiol of which cysteine is the limiting amino acid for GSH biosynthesis. In fact, CSCs over-express xCT, a cystine transporter stabilized on ce...
Main Authors: | Lorenzo Monteleone, Andrea Speciale, Giulia Elda Valenti, Nicola Traverso, Silvia Ravera, Ombretta Garbarino, Riccardo Leardi, Emanuele Farinini, Antonella Roveri, Fulvio Ursini, Claudia Cantoni, Maria Adelaide Pronzato, Umberto Maria Marinari, Barbara Marengo, Cinzia Domenicotti |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2021-04-01
|
Series: | Antioxidants |
Subjects: | |
Online Access: | https://www.mdpi.com/2076-3921/10/5/691 |
Similar Items
-
Production and purification of homogenous recombinant human selenoproteins reveals a unique codon skipping event in E. coli and GPX4-specific affinity to bromosulfophthalein
by: Qing Cheng, et al.
Published: (2021-10-01) -
Ferroptosis and Its Role in Epilepsy
by: Yuxiang Cai, et al.
Published: (2021-07-01) -
Ferroptosis in Cancer Cell Biology
by: Christina M. Bebber, et al.
Published: (2020-01-01) -
Lipid Metabolism and Ferroptosis
by: Ji-Yoon Lee, et al.
Published: (2021-03-01) -
A Potential Mechanism of Temozolomide Resistance in Glioma–Ferroptosis
by: Zhifang Hu, et al.
Published: (2020-06-01)