Biological Activities of Aerial Parts Extracts of Euphorbia characias
The aim of the present study was to evaluate antioxidant, antimicrobial, anti-HIV, and cholinesterase inhibitory activities of aqueous and alcoholic extracts from leaves, stems, and flowers of Euphorbia characias. The extracts showed a high antioxidant activity and were a good source of total polyph...
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doaj-472be63c7de44e9aa41f92c640e6bbb82020-11-25T00:02:52ZengHindawi LimitedBioMed Research International2314-61332314-61412016-01-01201610.1155/2016/15387031538703Biological Activities of Aerial Parts Extracts of Euphorbia characiasMaria Barbara Pisano0Sofia Cosentino1Silvia Viale2Delia Spanò3Angela Corona4Francesca Esposito5Enzo Tramontano6Paola Montoro7Carlo Ignazio Giovanni Tuberoso8Rosaria Medda9Francesca Pintus10Department of Public Health, Clinical and Molecular Medicine, University of Cagliari, Cittadella Universitaria, 09042 Monserrato, ItalyDepartment of Public Health, Clinical and Molecular Medicine, University of Cagliari, Cittadella Universitaria, 09042 Monserrato, ItalyDepartment of Public Health, Clinical and Molecular Medicine, University of Cagliari, Cittadella Universitaria, 09042 Monserrato, ItalyDepartment of Sciences of Life and Environment, University of Cagliari, Cittadella Universitaria, 09042 Monserrato, ItalyDepartment of Sciences of Life and Environment, University of Cagliari, Cittadella Universitaria, 09042 Monserrato, ItalyDepartment of Sciences of Life and Environment, University of Cagliari, Cittadella Universitaria, 09042 Monserrato, ItalyDepartment of Sciences of Life and Environment, University of Cagliari, Cittadella Universitaria, 09042 Monserrato, ItalyDepartment of Pharmacy, University of Salerno, 84084 Fisciano, ItalyDepartment of Sciences of Life and Environment, University of Cagliari, Cittadella Universitaria, 09042 Monserrato, ItalyDepartment of Sciences of Life and Environment, University of Cagliari, Cittadella Universitaria, 09042 Monserrato, ItalyDepartment of Sciences of Life and Environment, University of Cagliari, Cittadella Universitaria, 09042 Monserrato, ItalyThe aim of the present study was to evaluate antioxidant, antimicrobial, anti-HIV, and cholinesterase inhibitory activities of aqueous and alcoholic extracts from leaves, stems, and flowers of Euphorbia characias. The extracts showed a high antioxidant activity and were a good source of total polyphenols and flavonoids. Ethanolic extracts from leaves and flowers displayed the highest inhibitory activity against acetylcholinesterase and butyrylcholinesterase, showing potential properties against Alzheimer’s disease. Antimicrobial assay showed that leaves and flowers extracts were active against all Gram-positive bacteria tested. The ethanolic leaves extract appeared to have the strongest antibacterial activity against Bacillus cereus with MIC value of 312.5 μg/mL followed by Listeria monocytogenes and Staphylococcus aureus that also exhibited good sensitivity with MIC values of 1250 μg/mL. Moreover, all the extracts possessed anti-HIV activity. The ethanolic flower extract was the most potent inhibitor of HIV-1 RT DNA polymerase RNA-dependent and Ribonuclease H with IC50 values of 0.26 and 0.33 μg/mL, respectively. The LC-DAD metabolic profile showed that ethanolic leaves extract contains high levels of quercetin derivatives. This study suggests that Euphorbia characias extracts represent a good source of natural bioactive compounds which could be useful for pharmaceutical application as well as in food system for the prevention of the growth of food-borne bacteria and to extend the shelf-life of processed foods.http://dx.doi.org/10.1155/2016/1538703 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Maria Barbara Pisano Sofia Cosentino Silvia Viale Delia Spanò Angela Corona Francesca Esposito Enzo Tramontano Paola Montoro Carlo Ignazio Giovanni Tuberoso Rosaria Medda Francesca Pintus |
spellingShingle |
Maria Barbara Pisano Sofia Cosentino Silvia Viale Delia Spanò Angela Corona Francesca Esposito Enzo Tramontano Paola Montoro Carlo Ignazio Giovanni Tuberoso Rosaria Medda Francesca Pintus Biological Activities of Aerial Parts Extracts of Euphorbia characias BioMed Research International |
author_facet |
Maria Barbara Pisano Sofia Cosentino Silvia Viale Delia Spanò Angela Corona Francesca Esposito Enzo Tramontano Paola Montoro Carlo Ignazio Giovanni Tuberoso Rosaria Medda Francesca Pintus |
author_sort |
Maria Barbara Pisano |
title |
Biological Activities of Aerial Parts Extracts of Euphorbia characias |
title_short |
Biological Activities of Aerial Parts Extracts of Euphorbia characias |
title_full |
Biological Activities of Aerial Parts Extracts of Euphorbia characias |
title_fullStr |
Biological Activities of Aerial Parts Extracts of Euphorbia characias |
title_full_unstemmed |
Biological Activities of Aerial Parts Extracts of Euphorbia characias |
title_sort |
biological activities of aerial parts extracts of euphorbia characias |
publisher |
Hindawi Limited |
series |
BioMed Research International |
issn |
2314-6133 2314-6141 |
publishDate |
2016-01-01 |
description |
The aim of the present study was to evaluate antioxidant, antimicrobial, anti-HIV, and cholinesterase inhibitory activities of aqueous and alcoholic extracts from leaves, stems, and flowers of Euphorbia characias. The extracts showed a high antioxidant activity and were a good source of total polyphenols and flavonoids. Ethanolic extracts from leaves and flowers displayed the highest inhibitory activity against acetylcholinesterase and butyrylcholinesterase, showing potential properties against Alzheimer’s disease. Antimicrobial assay showed that leaves and flowers extracts were active against all Gram-positive bacteria tested. The ethanolic leaves extract appeared to have the strongest antibacterial activity against Bacillus cereus with MIC value of 312.5 μg/mL followed by Listeria monocytogenes and Staphylococcus aureus that also exhibited good sensitivity with MIC values of 1250 μg/mL. Moreover, all the extracts possessed anti-HIV activity. The ethanolic flower extract was the most potent inhibitor of HIV-1 RT DNA polymerase RNA-dependent and Ribonuclease H with IC50 values of 0.26 and 0.33 μg/mL, respectively. The LC-DAD metabolic profile showed that ethanolic leaves extract contains high levels of quercetin derivatives. This study suggests that Euphorbia characias extracts represent a good source of natural bioactive compounds which could be useful for pharmaceutical application as well as in food system for the prevention of the growth of food-borne bacteria and to extend the shelf-life of processed foods. |
url |
http://dx.doi.org/10.1155/2016/1538703 |
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