Ceruloplasmin, a potential marker for glycemic status and its relationship with lipid profile in Type II diabetes mellitus
Background: Type II Diabetes Mellitus (Type II DM) is a metabolic disorder characterized by glucotoxicity and lipotoxicity. Marker of glycemic control are HbA1c, fasting blood glucose and postprandial blood glucose. There is altered lipid parameters in Type II DM which possess significant cardiovasc...
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Manipal College of Medical Sciences, Pokhara
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doaj-47351f78d2df4ba78a5ae6d21e5ba5692020-11-25T02:50:09ZengManipal College of Medical Sciences, PokharaAsian Journal of Medical Sciences2467-91002091-05762018-03-01921318https://doi.org/10.3126/ajms.v9i2.19003Ceruloplasmin, a potential marker for glycemic status and its relationship with lipid profile in Type II diabetes mellitusVijay Kumar Sharma 0Arjun Tumbapo 1Vivek Pant2Binod Aryal 3Sweta Shrestha 4Binod Kumar Yadav 5Eans Tara Tuladhar 6Aseem Bhattarai 7Mithileshwor Raut 8Assistant Professor, Department of Biochemistry, Institute of Medicine, Tribhuvan University Teaching HospitalResident Doctor, Department of Biochemistry, Institute of Medicine, Tribhuvan University Teaching HospitalResident Doctor, Department of Biochemistry, Institute of Medicine, Tribhuvan University Teaching HospitalMasters Student, Department of Biochemistry, Institute of Medicine, Tribhuvan University Teaching HospitalMasters Student, Department of Biochemistry, Institute of Medicine, Tribhuvan University Teaching HospitalAssociate Professor, Department of Biochemistry, Institute of Medicine, Tribhuvan University Teaching HospitalAssistant Professor, Department of Biochemistry, Institute of Medicine, Tribhuvan University Teaching HospitalAssistant Professor, Department of Biochemistry, Institute of Medicine, Tribhuvan University Teaching HospitalAssistant Professor, Department of Biochemistry, Institute of Medicine, Tribhuvan University Teaching HospitalBackground: Type II Diabetes Mellitus (Type II DM) is a metabolic disorder characterized by glucotoxicity and lipotoxicity. Marker of glycemic control are HbA1c, fasting blood glucose and postprandial blood glucose. There is altered lipid parameters in Type II DM which possess significant cardiovascular risk to the patient. Recent studies have shown that ceruloplasmin, an inflammatory marker having antioxidant property,is ideal marker to know the cardiovascular status, degree of insulin resistance and cancer risk. Aims and Objectives: Present study was carried out to determine the relation between glycemic status and serum ceruloplasmin along with lipid parameters which reflects the cardiovascular status in these patients. Materials and Methods: Blood samples were collected from eighty-eight patients with type II diabetes mellitus along with age and sex matched forty-two healthy controls. Fasting lipid profile and blood glucose, postprandial blood glucose, serum ceruloplasmin and HbA1c levels were determined using auto analyser in the department of clinical biochemistry in Institute of Medicine.Appropriate tests of significance were computed by SPSS version 20. Results: Serum ceruloplasmin was found higher in type II DM than non-diabetic group, median 52.0 (95% CI: 49-53) mg/dl versus median 45.0 (95% CI: 41-47) mg/dl, at significant level of 0.001 probability test. Similarly, fasting blood glucose, post prandial glucose, HbA1c and TG/HDL cholesterol ratio correlated significantly with serum ceruloplasmin.The cut off value of 46.5 mg/dL was obtained for serum ceruloplasmin with sensitivity of 87.5% and specificity of 62% which has good discriminating value for type II diabetic patients versus non-diabetic patients. Conclusion: Findings in our study shows that increased glycation coupled with altered lipid profile in type II DM causes enhanced generation of ceruloplasmin which could be used as potential marker for identifying acceleratedglycation and atherogenesis in these subjects.https://www.nepjol.info/index.php/AJMS/article/view/19003type ii dmceruloplasminlipid profilelipid ratio |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Vijay Kumar Sharma Arjun Tumbapo Vivek Pant Binod Aryal Sweta Shrestha Binod Kumar Yadav Eans Tara Tuladhar Aseem Bhattarai Mithileshwor Raut |
spellingShingle |
Vijay Kumar Sharma Arjun Tumbapo Vivek Pant Binod Aryal Sweta Shrestha Binod Kumar Yadav Eans Tara Tuladhar Aseem Bhattarai Mithileshwor Raut Ceruloplasmin, a potential marker for glycemic status and its relationship with lipid profile in Type II diabetes mellitus Asian Journal of Medical Sciences type ii dm ceruloplasmin lipid profile lipid ratio |
author_facet |
Vijay Kumar Sharma Arjun Tumbapo Vivek Pant Binod Aryal Sweta Shrestha Binod Kumar Yadav Eans Tara Tuladhar Aseem Bhattarai Mithileshwor Raut |
author_sort |
Vijay Kumar Sharma |
title |
Ceruloplasmin, a potential marker for glycemic status and its relationship with lipid profile in Type II diabetes mellitus |
title_short |
Ceruloplasmin, a potential marker for glycemic status and its relationship with lipid profile in Type II diabetes mellitus |
title_full |
Ceruloplasmin, a potential marker for glycemic status and its relationship with lipid profile in Type II diabetes mellitus |
title_fullStr |
Ceruloplasmin, a potential marker for glycemic status and its relationship with lipid profile in Type II diabetes mellitus |
title_full_unstemmed |
Ceruloplasmin, a potential marker for glycemic status and its relationship with lipid profile in Type II diabetes mellitus |
title_sort |
ceruloplasmin, a potential marker for glycemic status and its relationship with lipid profile in type ii diabetes mellitus |
publisher |
Manipal College of Medical Sciences, Pokhara |
series |
Asian Journal of Medical Sciences |
issn |
2467-9100 2091-0576 |
publishDate |
2018-03-01 |
description |
Background: Type II Diabetes Mellitus (Type II DM) is a metabolic disorder characterized by glucotoxicity and lipotoxicity. Marker of glycemic control are HbA1c, fasting blood glucose and postprandial blood glucose. There is altered lipid parameters in Type II DM which possess significant cardiovascular risk to the patient. Recent studies have shown that ceruloplasmin, an inflammatory marker having antioxidant property,is ideal marker to know the cardiovascular status, degree of insulin resistance and cancer risk.
Aims and Objectives: Present study was carried out to determine the relation between glycemic status and serum ceruloplasmin along with lipid parameters which reflects the cardiovascular status in these patients.
Materials and Methods: Blood samples were collected from eighty-eight patients with type II diabetes mellitus along with age and sex matched forty-two healthy controls. Fasting lipid profile and blood glucose, postprandial blood glucose, serum ceruloplasmin and HbA1c levels were determined using auto analyser in the department of clinical biochemistry in Institute of Medicine.Appropriate tests of significance were computed by SPSS version 20.
Results: Serum ceruloplasmin was found higher in type II DM than non-diabetic group, median 52.0 (95% CI: 49-53) mg/dl versus median 45.0 (95% CI: 41-47) mg/dl, at significant level of 0.001 probability test. Similarly, fasting blood glucose, post prandial glucose, HbA1c and TG/HDL cholesterol ratio correlated significantly with serum ceruloplasmin.The cut off value of 46.5 mg/dL was obtained for serum ceruloplasmin with sensitivity of 87.5% and specificity of 62% which has good discriminating value for type II diabetic patients versus non-diabetic patients.
Conclusion: Findings in our study shows that increased glycation coupled with altered lipid profile in type II DM causes enhanced generation of ceruloplasmin which could be used as potential marker for identifying acceleratedglycation and atherogenesis in these subjects. |
topic |
type ii dm ceruloplasmin lipid profile lipid ratio |
url |
https://www.nepjol.info/index.php/AJMS/article/view/19003 |
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