Functional MRI (fMRI) Evaluation of Hyperbaric Oxygen Therapy (HBOT) Efficacy in Chronic Cerebral Stroke: A Small Retrospective Consecutive Case Series
<b>Topics:</b> Functional Magnetic Resonance Imaging (fMRI) evaluation of HyberBaric Oxygen Therapy (HBOT) effects on chronic cerebral stroke Patients (Pts). <b>Introduction:</b> Our aim was to evaluate with fMRI, in a 3 Tesla system, the functional effects of HBOT on the Cen...
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doaj-473578f919c6495d82283d3dae0047c62020-12-30T00:05:00ZengMDPI AGInternational Journal of Environmental Research and Public Health1661-78271660-46012021-12-011819019010.3390/ijerph18010190Functional MRI (fMRI) Evaluation of Hyperbaric Oxygen Therapy (HBOT) Efficacy in Chronic Cerebral Stroke: A Small Retrospective Consecutive Case SeriesDaniela Cevolani0Ferruccio Di Donato1Luigi Santarella2Simone Bertossi3Martino Cellerini4Department of Experimental, Diagnostic and Specialty Medicine (DIMES), University of Bologna, c/o Neuroradiology Unit, “Bellaria” Hospital, 40139 Bologna, ItalyHyperbaric Centre of Bologna, Quarto Inferiore, 40057 Bologna, ItalyHyperbaric Centre of Bologna, Quarto Inferiore, 40057 Bologna, ItalyHyperbaric Centre of Bologna, Quarto Inferiore, 40057 Bologna, ItalyNeuroradiology Unit, “Bellaria” Hospital, IRCCS Institute of Neurological Sciences, 40139 Bologna, Italy<b>Topics:</b> Functional Magnetic Resonance Imaging (fMRI) evaluation of HyberBaric Oxygen Therapy (HBOT) effects on chronic cerebral stroke Patients (Pts). <b>Introduction:</b> Our aim was to evaluate with fMRI, in a 3 Tesla system, the functional effects of HBOT on the Central Nervous System (CNS) in four Pts with established ischaemic and haemorrhagic cerebral strokes (2 Pts each). To our knowledge, no author used this Magnetic Resonance (MR) technique for this purpose, till now. <b>Methods:</b> All four Pts underwent a fMRI study before and after 40 HBOT sessions, with a time window of a few days. They carried out two language (text listening, silent word-verb generation) and two motor (hand and foot movements) tasks (30 s On-Off block paradigms). <b>Results:</b> After HBOT, all Pts reported a clinical improvement, mostly concerning language fluency and motor paresis. fMRI analysis demonstrated an increase in both the extent and the statistical significance of most of the examined eloquent areas. <b>Conclusions:</b> These changes were consistent with the clinical improvement in all Pts, suggesting a possible role of fMRI in revealing neuronal functional correlates of neuronal plasticity and HBOT-related neoangiogenesis. Although only four Pts were examined, fMRI proved to be a sensitive, non-invasive and reliable modality for monitoring neuronal functional changes before and after HBOT.https://www.mdpi.com/1660-4601/18/1/190HyperBaric Oxygen Therapy (HBOT)chronic cerebral strokeBlood Oxygenation Level-Dependent (BOLD) signalfunctional Magnetic Resonance Imaging (fMRI) |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Daniela Cevolani Ferruccio Di Donato Luigi Santarella Simone Bertossi Martino Cellerini |
spellingShingle |
Daniela Cevolani Ferruccio Di Donato Luigi Santarella Simone Bertossi Martino Cellerini Functional MRI (fMRI) Evaluation of Hyperbaric Oxygen Therapy (HBOT) Efficacy in Chronic Cerebral Stroke: A Small Retrospective Consecutive Case Series International Journal of Environmental Research and Public Health HyperBaric Oxygen Therapy (HBOT) chronic cerebral stroke Blood Oxygenation Level-Dependent (BOLD) signal functional Magnetic Resonance Imaging (fMRI) |
author_facet |
Daniela Cevolani Ferruccio Di Donato Luigi Santarella Simone Bertossi Martino Cellerini |
author_sort |
Daniela Cevolani |
title |
Functional MRI (fMRI) Evaluation of Hyperbaric Oxygen Therapy (HBOT) Efficacy in Chronic Cerebral Stroke: A Small Retrospective Consecutive Case Series |
title_short |
Functional MRI (fMRI) Evaluation of Hyperbaric Oxygen Therapy (HBOT) Efficacy in Chronic Cerebral Stroke: A Small Retrospective Consecutive Case Series |
title_full |
Functional MRI (fMRI) Evaluation of Hyperbaric Oxygen Therapy (HBOT) Efficacy in Chronic Cerebral Stroke: A Small Retrospective Consecutive Case Series |
title_fullStr |
Functional MRI (fMRI) Evaluation of Hyperbaric Oxygen Therapy (HBOT) Efficacy in Chronic Cerebral Stroke: A Small Retrospective Consecutive Case Series |
title_full_unstemmed |
Functional MRI (fMRI) Evaluation of Hyperbaric Oxygen Therapy (HBOT) Efficacy in Chronic Cerebral Stroke: A Small Retrospective Consecutive Case Series |
title_sort |
functional mri (fmri) evaluation of hyperbaric oxygen therapy (hbot) efficacy in chronic cerebral stroke: a small retrospective consecutive case series |
publisher |
MDPI AG |
series |
International Journal of Environmental Research and Public Health |
issn |
1661-7827 1660-4601 |
publishDate |
2021-12-01 |
description |
<b>Topics:</b> Functional Magnetic Resonance Imaging (fMRI) evaluation of HyberBaric Oxygen Therapy (HBOT) effects on chronic cerebral stroke Patients (Pts). <b>Introduction:</b> Our aim was to evaluate with fMRI, in a 3 Tesla system, the functional effects of HBOT on the Central Nervous System (CNS) in four Pts with established ischaemic and haemorrhagic cerebral strokes (2 Pts each). To our knowledge, no author used this Magnetic Resonance (MR) technique for this purpose, till now. <b>Methods:</b> All four Pts underwent a fMRI study before and after 40 HBOT sessions, with a time window of a few days. They carried out two language (text listening, silent word-verb generation) and two motor (hand and foot movements) tasks (30 s On-Off block paradigms). <b>Results:</b> After HBOT, all Pts reported a clinical improvement, mostly concerning language fluency and motor paresis. fMRI analysis demonstrated an increase in both the extent and the statistical significance of most of the examined eloquent areas. <b>Conclusions:</b> These changes were consistent with the clinical improvement in all Pts, suggesting a possible role of fMRI in revealing neuronal functional correlates of neuronal plasticity and HBOT-related neoangiogenesis. Although only four Pts were examined, fMRI proved to be a sensitive, non-invasive and reliable modality for monitoring neuronal functional changes before and after HBOT. |
topic |
HyperBaric Oxygen Therapy (HBOT) chronic cerebral stroke Blood Oxygenation Level-Dependent (BOLD) signal functional Magnetic Resonance Imaging (fMRI) |
url |
https://www.mdpi.com/1660-4601/18/1/190 |
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