The Role of MicroRNA as Clinical Biomarkers for Breast Cancer Surgery and Treatment
Breast cancer is the most common cancer diagnosed in women. In recent times, survival outcomes have improved dramatically in accordance with our enhanced understanding of the molecular processes driving breast cancer proliferation and development. Refined surgical approaches, combined with novel and...
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doaj-4738c45f314d4d95b4dd1695933bd52a2021-08-06T15:26:11ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-08-01228290829010.3390/ijms22158290The Role of MicroRNA as Clinical Biomarkers for Breast Cancer Surgery and TreatmentMatthew G. Davey0Molly Davies1Aoife J. Lowery2Nicola Miller3Michael J. Kerin4Department of Surgery, The Lambe Institute for Translational Research, National University of Ireland, Galway, H91 YR71 Galway, IrelandDepartment of Surgery, The Lambe Institute for Translational Research, National University of Ireland, Galway, H91 YR71 Galway, IrelandDepartment of Surgery, The Lambe Institute for Translational Research, National University of Ireland, Galway, H91 YR71 Galway, IrelandDepartment of Surgery, The Lambe Institute for Translational Research, National University of Ireland, Galway, H91 YR71 Galway, IrelandDepartment of Surgery, The Lambe Institute for Translational Research, National University of Ireland, Galway, H91 YR71 Galway, IrelandBreast cancer is the most common cancer diagnosed in women. In recent times, survival outcomes have improved dramatically in accordance with our enhanced understanding of the molecular processes driving breast cancer proliferation and development. Refined surgical approaches, combined with novel and targeted treatment options, have aided the personalisation of breast cancer patient care. Despite this, some patients will unfortunately succumb to the disease. In recent times, translational research efforts have been focused on identifying novel biomarkers capable of informing patient outcome; microRNAs (miRNAs) are small non-coding molecules, which regulate gene expression at a post-transcriptional level. Aberrant miRNA expression profiles have been observed in cancer proliferation and development. The measurement and correlation of miRNA expression levels with oncological outcomes such as response to current conventional therapies, and disease recurrence are being investigated. Herein, we outline the clinical utility of miRNA expression profiles in informing breast cancer prognosis, predicting response to treatment strategies as well as their potential as therapeutic targets to enhance treatment modalities in the era of precision oncology.https://www.mdpi.com/1422-0067/22/15/8290breast cancermiRNAnon-coding RNAprecision oncologypersonalised medicine |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Matthew G. Davey Molly Davies Aoife J. Lowery Nicola Miller Michael J. Kerin |
spellingShingle |
Matthew G. Davey Molly Davies Aoife J. Lowery Nicola Miller Michael J. Kerin The Role of MicroRNA as Clinical Biomarkers for Breast Cancer Surgery and Treatment International Journal of Molecular Sciences breast cancer miRNA non-coding RNA precision oncology personalised medicine |
author_facet |
Matthew G. Davey Molly Davies Aoife J. Lowery Nicola Miller Michael J. Kerin |
author_sort |
Matthew G. Davey |
title |
The Role of MicroRNA as Clinical Biomarkers for Breast Cancer Surgery and Treatment |
title_short |
The Role of MicroRNA as Clinical Biomarkers for Breast Cancer Surgery and Treatment |
title_full |
The Role of MicroRNA as Clinical Biomarkers for Breast Cancer Surgery and Treatment |
title_fullStr |
The Role of MicroRNA as Clinical Biomarkers for Breast Cancer Surgery and Treatment |
title_full_unstemmed |
The Role of MicroRNA as Clinical Biomarkers for Breast Cancer Surgery and Treatment |
title_sort |
role of microrna as clinical biomarkers for breast cancer surgery and treatment |
publisher |
MDPI AG |
series |
International Journal of Molecular Sciences |
issn |
1661-6596 1422-0067 |
publishDate |
2021-08-01 |
description |
Breast cancer is the most common cancer diagnosed in women. In recent times, survival outcomes have improved dramatically in accordance with our enhanced understanding of the molecular processes driving breast cancer proliferation and development. Refined surgical approaches, combined with novel and targeted treatment options, have aided the personalisation of breast cancer patient care. Despite this, some patients will unfortunately succumb to the disease. In recent times, translational research efforts have been focused on identifying novel biomarkers capable of informing patient outcome; microRNAs (miRNAs) are small non-coding molecules, which regulate gene expression at a post-transcriptional level. Aberrant miRNA expression profiles have been observed in cancer proliferation and development. The measurement and correlation of miRNA expression levels with oncological outcomes such as response to current conventional therapies, and disease recurrence are being investigated. Herein, we outline the clinical utility of miRNA expression profiles in informing breast cancer prognosis, predicting response to treatment strategies as well as their potential as therapeutic targets to enhance treatment modalities in the era of precision oncology. |
topic |
breast cancer miRNA non-coding RNA precision oncology personalised medicine |
url |
https://www.mdpi.com/1422-0067/22/15/8290 |
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