T-lineage acute lymphoblastic leukemia and parvovirus infection in a child with neurofibromastosis-1

• Main Authors: Pallavi Agarwal, Shano Naseem, Neelam Varma, R K Marwaha
• Format: Article
• Language: English
• Published: Wolters Kluwer Medknow Publications 2013-01-01
• Series: Indian Journal of Pathology and Microbiology
• Subjects: Acute lymphoblastc leukemia; neurofibromatosis; parvovirus infection
• Online Access: http://www.ijpmonline.org/article.asp?issn=0377-4929;year=2013;volume=56;issue=4;spage=446;epage=448;aulast=Agarwal

Neurofibromatosis (NF-1) patients have an increased risk of developing malignancies most commonly rhabdomyosarcomas, optic gliomas, brain tumors and non-lymphocytic leukemias. Acute lymphoblastic leukemia (ALL) has been infrequently reported in association with NF-1. We describe a rare association of NF-1, T-lineage ALL and parvovirus infection in a 12-year-old child. In addition, it is also to emphasize that a high index of suspicion should be kept for parvovirus B19 infection as a cause of bicytopenia/pancytopenia in ALL patients following induction chemotherapy.