Fragile temporal prediction in patients with schizophrenia is related to minimal self disorders
Abstract Patients with schizophrenia have difficulty in making sensory predictions, in the time domain, which have been proposed to be related to self-disorders. However experimental evidence is lacking. We examined both voluntary and automatic forms of temporal prediction in 28 patients and 24 matc...
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doaj-4755f56125504a8e82bd1238be1088ca2020-12-08T00:26:30ZengNature Publishing GroupScientific Reports2045-23222017-08-017111010.1038/s41598-017-07987-yFragile temporal prediction in patients with schizophrenia is related to minimal self disordersBrice Martin0Nicolas Franck1Michel Cermolacce2Agnès Falco3Anabel Benair4Estelle Etienne5Sébastien Weibel6Jennifer T. Coull7Anne Giersch8Centre Ressource de Réhabilitation psychosociale et de remédiation cognitive, Centre Référent Lyonnais en Réhabilitation et en Remédiation cognitive (CL3R) Hôpital du Vinatier; CNRS UMR 5229Centre Ressource de Réhabilitation psychosociale et de remédiation cognitive, Centre Référent Lyonnais en Réhabilitation et en Remédiation cognitive (CL3R) Hôpital du Vinatier; CNRS UMR 5229Service Universitaire de Psychiatrie, Centre Hospitalier Universitaire Ste MargueriteCentre Ressource de Réhabilitation psychosociale et de remédiation cognitive, Centre Référent Lyonnais en Réhabilitation et en Remédiation cognitive (CL3R) Hôpital du Vinatier; CNRS UMR 5229Centre Ressource de Réhabilitation psychosociale et de remédiation cognitive, Centre Référent Lyonnais en Réhabilitation et en Remédiation cognitive (CL3R) Hôpital du Vinatier; CNRS UMR 5229Centre Ressource de Réhabilitation psychosociale et de remédiation cognitive, Centre Référent Lyonnais en Réhabilitation et en Remédiation cognitive (CL3R) Hôpital du Vinatier; CNRS UMR 5229INSERM U1114, Pôle de Psychiatrie, Fédération de Médecine Translationnelle de Strasbourg (FMTS), Centre Hospitalier Régional Universitaire of Strasbourg, Université de StrasbourgLaboratoire des Neurosciences Cognitives (UMR 7291), Aix-Marseille Université & CNRSINSERM U1114, Pôle de Psychiatrie, Fédération de Médecine Translationnelle de Strasbourg (FMTS), Centre Hospitalier Régional Universitaire of Strasbourg, Université de StrasbourgAbstract Patients with schizophrenia have difficulty in making sensory predictions, in the time domain, which have been proposed to be related to self-disorders. However experimental evidence is lacking. We examined both voluntary and automatic forms of temporal prediction in 28 patients and 24 matched controls. A visual cue predicted (temporal cue) or not (neutral cue) the time (400 ms/1000 ms) at which a subsequent target was presented. In both patients and controls, RTs were faster for targets presented after long versus short intervals due to the temporal predictability inherent in the elapse of time (“hazard function”). This RT benefit was correlated with scores on the EASE scale, which measures disorders of the self: patients with a high ‘self-awareness and presence’ score did not show any significant benefit of the hazard function, whereas this ability was preserved in patients with a low score. Moreover, all patients were abnormally sensitive to the presence of “catch” trials (unexpected absence of a target) within a testing block, with RTs actually becoming slower at long versus short intervals. These results indicate fragility in patients’ ability to continuously extract temporally predictive information from the elapsing interval. This deficit might contribute to perturbations of the minimal self in patients.https://doi.org/10.1038/s41598-017-07987-y |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Brice Martin Nicolas Franck Michel Cermolacce Agnès Falco Anabel Benair Estelle Etienne Sébastien Weibel Jennifer T. Coull Anne Giersch |
spellingShingle |
Brice Martin Nicolas Franck Michel Cermolacce Agnès Falco Anabel Benair Estelle Etienne Sébastien Weibel Jennifer T. Coull Anne Giersch Fragile temporal prediction in patients with schizophrenia is related to minimal self disorders Scientific Reports |
author_facet |
Brice Martin Nicolas Franck Michel Cermolacce Agnès Falco Anabel Benair Estelle Etienne Sébastien Weibel Jennifer T. Coull Anne Giersch |
author_sort |
Brice Martin |
title |
Fragile temporal prediction in patients with schizophrenia is related to minimal self disorders |
title_short |
Fragile temporal prediction in patients with schizophrenia is related to minimal self disorders |
title_full |
Fragile temporal prediction in patients with schizophrenia is related to minimal self disorders |
title_fullStr |
Fragile temporal prediction in patients with schizophrenia is related to minimal self disorders |
title_full_unstemmed |
Fragile temporal prediction in patients with schizophrenia is related to minimal self disorders |
title_sort |
fragile temporal prediction in patients with schizophrenia is related to minimal self disorders |
publisher |
Nature Publishing Group |
series |
Scientific Reports |
issn |
2045-2322 |
publishDate |
2017-08-01 |
description |
Abstract Patients with schizophrenia have difficulty in making sensory predictions, in the time domain, which have been proposed to be related to self-disorders. However experimental evidence is lacking. We examined both voluntary and automatic forms of temporal prediction in 28 patients and 24 matched controls. A visual cue predicted (temporal cue) or not (neutral cue) the time (400 ms/1000 ms) at which a subsequent target was presented. In both patients and controls, RTs were faster for targets presented after long versus short intervals due to the temporal predictability inherent in the elapse of time (“hazard function”). This RT benefit was correlated with scores on the EASE scale, which measures disorders of the self: patients with a high ‘self-awareness and presence’ score did not show any significant benefit of the hazard function, whereas this ability was preserved in patients with a low score. Moreover, all patients were abnormally sensitive to the presence of “catch” trials (unexpected absence of a target) within a testing block, with RTs actually becoming slower at long versus short intervals. These results indicate fragility in patients’ ability to continuously extract temporally predictive information from the elapsing interval. This deficit might contribute to perturbations of the minimal self in patients. |
url |
https://doi.org/10.1038/s41598-017-07987-y |
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