Effects of Vitamin E on Cognitive Performance during Ageing and in Alzheimer’s Disease
Vitamin E is an important antioxidant that primarily protects cells from damage associated with oxidative stress caused by free radicals. The brain is highly susceptible to oxidative stress, which increases during ageing and is considered a major contributor to neurodegeneration. High plasma vitamin...
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2014-11-01
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doaj-47565f9b22164d4badd023ad1f0869a92020-11-24T23:01:26ZengMDPI AGNutrients2072-66432014-11-016125453547210.3390/nu6125453nu6125453Effects of Vitamin E on Cognitive Performance during Ageing and in Alzheimer’s DiseaseGiorgio La Fata0Peter Weber1M. Hasan Mohajeri2DSM Nutritional Products Ltd., R & D Human Nutrition and Health, P.O. Box 2676, CH-4002 Basel, SwitzerlandDSM Nutritional Products Ltd., R & D Human Nutrition and Health, P.O. Box 2676, CH-4002 Basel, SwitzerlandDSM Nutritional Products Ltd., R & D Human Nutrition and Health, P.O. Box 2676, CH-4002 Basel, SwitzerlandVitamin E is an important antioxidant that primarily protects cells from damage associated with oxidative stress caused by free radicals. The brain is highly susceptible to oxidative stress, which increases during ageing and is considered a major contributor to neurodegeneration. High plasma vitamin E levels were repeatedly associated with better cognitive performance. Due to its antioxidant properties, the ability of vitamin E to prevent or delay cognitive decline has been tested in clinical trials in both ageing population and Alzheimer’s disease (AD) patients. The difficulty in performing precise and uniform human studies is mostly responsible for the inconsistent outcomes reported in the literature. Therefore, the benefit of vitamin E as a treatment for neurodegenerative disorders is still under debate. In this review, we focus on those studies that mostly have contributed to clarifying the exclusive function of vitamin E in relation to brain ageing and AD.http://www.mdpi.com/2072-6643/6/12/5453α-tocopherolantioxidantoxidative stressbrain ageingAD |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Giorgio La Fata Peter Weber M. Hasan Mohajeri |
spellingShingle |
Giorgio La Fata Peter Weber M. Hasan Mohajeri Effects of Vitamin E on Cognitive Performance during Ageing and in Alzheimer’s Disease Nutrients α-tocopherol antioxidant oxidative stress brain ageing AD |
author_facet |
Giorgio La Fata Peter Weber M. Hasan Mohajeri |
author_sort |
Giorgio La Fata |
title |
Effects of Vitamin E on Cognitive Performance during Ageing and in Alzheimer’s Disease |
title_short |
Effects of Vitamin E on Cognitive Performance during Ageing and in Alzheimer’s Disease |
title_full |
Effects of Vitamin E on Cognitive Performance during Ageing and in Alzheimer’s Disease |
title_fullStr |
Effects of Vitamin E on Cognitive Performance during Ageing and in Alzheimer’s Disease |
title_full_unstemmed |
Effects of Vitamin E on Cognitive Performance during Ageing and in Alzheimer’s Disease |
title_sort |
effects of vitamin e on cognitive performance during ageing and in alzheimer’s disease |
publisher |
MDPI AG |
series |
Nutrients |
issn |
2072-6643 |
publishDate |
2014-11-01 |
description |
Vitamin E is an important antioxidant that primarily protects cells from damage associated with oxidative stress caused by free radicals. The brain is highly susceptible to oxidative stress, which increases during ageing and is considered a major contributor to neurodegeneration. High plasma vitamin E levels were repeatedly associated with better cognitive performance. Due to its antioxidant properties, the ability of vitamin E to prevent or delay cognitive decline has been tested in clinical trials in both ageing population and Alzheimer’s disease (AD) patients. The difficulty in performing precise and uniform human studies is mostly responsible for the inconsistent outcomes reported in the literature. Therefore, the benefit of vitamin E as a treatment for neurodegenerative disorders is still under debate. In this review, we focus on those studies that mostly have contributed to clarifying the exclusive function of vitamin E in relation to brain ageing and AD. |
topic |
α-tocopherol antioxidant oxidative stress brain ageing AD |
url |
http://www.mdpi.com/2072-6643/6/12/5453 |
work_keys_str_mv |
AT giorgiolafata effectsofvitamineoncognitiveperformanceduringageingandinalzheimersdisease AT peterweber effectsofvitamineoncognitiveperformanceduringageingandinalzheimersdisease AT mhasanmohajeri effectsofvitamineoncognitiveperformanceduringageingandinalzheimersdisease |
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