Evaluation of ocular involvement in patients with Hansen's disease.
Hansen's disease (HD) belongs to the group of neglected diseases and can cause physical deformities and disabilities, in addition to leading to social discrimination. Ocular involvement in HD is estimated at 70-75% worldwide. About 10-50% suffer from severe ocular symptoms and loss of vision oc...
Main Authors: | , , , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2020-09-01
|
Series: | PLoS Neglected Tropical Diseases |
Online Access: | https://doi.org/10.1371/journal.pntd.0008585 |
id |
doaj-4758a5f8a9bd4c67868b78544ebbf56f |
---|---|
record_format |
Article |
spelling |
doaj-4758a5f8a9bd4c67868b78544ebbf56f2021-03-03T07:58:56ZengPublic Library of Science (PLoS)PLoS Neglected Tropical Diseases1935-27271935-27352020-09-01149e000858510.1371/journal.pntd.0008585Evaluation of ocular involvement in patients with Hansen's disease.Priscila Daiane PavezziRodrigo Bueno do PradoPlinio Ângelo Boin FilhoAirton Dos Santos GonBruna TumaMarco Aurelio FornazieriFabiana de Mari ScaloneLuciana Rigolin Mazoni AlvesRicardo Hirayama MonteroAntonio Marcelo Barbante CasellaHansen's disease (HD) belongs to the group of neglected diseases and can cause physical deformities and disabilities, in addition to leading to social discrimination. Ocular involvement in HD is estimated at 70-75% worldwide. About 10-50% suffer from severe ocular symptoms and loss of vision occurs in approximately 5% of cases. Ocular changes may persist or worsen even after patients are considered cured and it is necessary to better understand these conditions in order to determine the need for additional public policies. The objective of this study was to identify the prevalence of ocular involvement in patients with HD at two specialist referral centers for treatment of the disease. A cross-sectional study was conducted with ophthalmological evaluations of patients with HD from June 2017 to June 2018. Diagnostic ocular findings, corrected visual acuity, and refractive error were described. Findings were correlated with patients' clinical and epidemiological variables. A total of 86 patients were evaluated, with a mean age of 50.1 years, predominantly males (59.3%), and with multibacillary HD (92%). The prevalence of ophthalmologic changes was 100% and the most common were dysfunction of the Meibomian glands (89.5%) and dry eye syndrome (81.4%). Cataracts were observed in 22 patients (25.6%), but best corrected visual acuity was normal or near normal in 84 patients (97.7%) and there were no cases of bilateral blindness. Patients with some degree of physical disability had more ophthalmological alterations, involving both the ocular adnexa (p = 0.03) and the ocular globe (p = 0.04). Ocular involvement is common in patients with Hansen's disease, reinforcing the importance of ophthalmologic examination in the evaluation and follow-up of these patients.https://doi.org/10.1371/journal.pntd.0008585 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Priscila Daiane Pavezzi Rodrigo Bueno do Prado Plinio Ângelo Boin Filho Airton Dos Santos Gon Bruna Tuma Marco Aurelio Fornazieri Fabiana de Mari Scalone Luciana Rigolin Mazoni Alves Ricardo Hirayama Montero Antonio Marcelo Barbante Casella |
spellingShingle |
Priscila Daiane Pavezzi Rodrigo Bueno do Prado Plinio Ângelo Boin Filho Airton Dos Santos Gon Bruna Tuma Marco Aurelio Fornazieri Fabiana de Mari Scalone Luciana Rigolin Mazoni Alves Ricardo Hirayama Montero Antonio Marcelo Barbante Casella Evaluation of ocular involvement in patients with Hansen's disease. PLoS Neglected Tropical Diseases |
author_facet |
Priscila Daiane Pavezzi Rodrigo Bueno do Prado Plinio Ângelo Boin Filho Airton Dos Santos Gon Bruna Tuma Marco Aurelio Fornazieri Fabiana de Mari Scalone Luciana Rigolin Mazoni Alves Ricardo Hirayama Montero Antonio Marcelo Barbante Casella |
author_sort |
Priscila Daiane Pavezzi |
title |
Evaluation of ocular involvement in patients with Hansen's disease. |
title_short |
Evaluation of ocular involvement in patients with Hansen's disease. |
title_full |
Evaluation of ocular involvement in patients with Hansen's disease. |
title_fullStr |
Evaluation of ocular involvement in patients with Hansen's disease. |
title_full_unstemmed |
Evaluation of ocular involvement in patients with Hansen's disease. |
title_sort |
evaluation of ocular involvement in patients with hansen's disease. |
publisher |
Public Library of Science (PLoS) |
series |
PLoS Neglected Tropical Diseases |
issn |
1935-2727 1935-2735 |
publishDate |
2020-09-01 |
description |
Hansen's disease (HD) belongs to the group of neglected diseases and can cause physical deformities and disabilities, in addition to leading to social discrimination. Ocular involvement in HD is estimated at 70-75% worldwide. About 10-50% suffer from severe ocular symptoms and loss of vision occurs in approximately 5% of cases. Ocular changes may persist or worsen even after patients are considered cured and it is necessary to better understand these conditions in order to determine the need for additional public policies. The objective of this study was to identify the prevalence of ocular involvement in patients with HD at two specialist referral centers for treatment of the disease. A cross-sectional study was conducted with ophthalmological evaluations of patients with HD from June 2017 to June 2018. Diagnostic ocular findings, corrected visual acuity, and refractive error were described. Findings were correlated with patients' clinical and epidemiological variables. A total of 86 patients were evaluated, with a mean age of 50.1 years, predominantly males (59.3%), and with multibacillary HD (92%). The prevalence of ophthalmologic changes was 100% and the most common were dysfunction of the Meibomian glands (89.5%) and dry eye syndrome (81.4%). Cataracts were observed in 22 patients (25.6%), but best corrected visual acuity was normal or near normal in 84 patients (97.7%) and there were no cases of bilateral blindness. Patients with some degree of physical disability had more ophthalmological alterations, involving both the ocular adnexa (p = 0.03) and the ocular globe (p = 0.04). Ocular involvement is common in patients with Hansen's disease, reinforcing the importance of ophthalmologic examination in the evaluation and follow-up of these patients. |
url |
https://doi.org/10.1371/journal.pntd.0008585 |
work_keys_str_mv |
AT prisciladaianepavezzi evaluationofocularinvolvementinpatientswithhansensdisease AT rodrigobuenodoprado evaluationofocularinvolvementinpatientswithhansensdisease AT plinioangeloboinfilho evaluationofocularinvolvementinpatientswithhansensdisease AT airtondossantosgon evaluationofocularinvolvementinpatientswithhansensdisease AT brunatuma evaluationofocularinvolvementinpatientswithhansensdisease AT marcoaureliofornazieri evaluationofocularinvolvementinpatientswithhansensdisease AT fabianademariscalone evaluationofocularinvolvementinpatientswithhansensdisease AT lucianarigolinmazonialves evaluationofocularinvolvementinpatientswithhansensdisease AT ricardohirayamamontero evaluationofocularinvolvementinpatientswithhansensdisease AT antoniomarcelobarbantecasella evaluationofocularinvolvementinpatientswithhansensdisease |
_version_ |
1714826867083575296 |