ATM-Mediated Phosphorylation of Cortactin Involved in Actin Polymerization Promotes Breast Cancer Cells Migration and Invasion

ATM-Mediated Phosphorylation of Cortactin Involved in Actin Polymerization Promotes Breast Cancer Cells Migration and Invasion

Background/Aims: The ataxia-telangiectasia mutated (ATM) protein kinase is critical for the maintenance of genomic stability and acts as tumor suppressor. Although evidence shows that a DNA damage-independent ATM (oxidized ATM) may be involved in cancer progression, the underlying mechanism is still...

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Main Authors: Lei Lang, Yixuan Hou, Yanlin Chen, Gang Tu, Jing Tao, Dan Yang, Lei Xi, Lixin Fu, Kexin Sun, Jiali Yin, Rui Chen, Meixi Peng, Shuiqing Liu, Manran Liu
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2018-12-01
Series:Cellular Physiology and Biochemistry
Subjects:
ATM
Cortactin
Hypoxia
Phosphorylation
Invasion
Online Access:https://www.karger.com/Article/FullText/496048

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