Biosynthesis of α-pyrones
The α-pyrone moiety is a structural feature found in a huge variety of biologically active metabolites. In recent times new insights into additional biosynthetic mechanisms, yielding in such six-membered unsaturated ester ring residues have been obtained. The purpose of this mini-review is to give a...
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Beilstein-Institut
2016-03-01
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| Series: | Beilstein Journal of Organic Chemistry |
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| Online Access: | https://doi.org/10.3762/bjoc.12.56 |
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doaj-47685d97457a4e3daa0c3b8c6230949b2021-02-02T08:28:35ZengBeilstein-InstitutBeilstein Journal of Organic Chemistry1860-53972016-03-0112157158810.3762/bjoc.12.561860-5397-12-56Biosynthesis of α-pyronesTill F. Schäberle0Institute for Pharmaceutical Biology, University of Bonn, Nußallee 6, 53115 Bonn, GermanyThe α-pyrone moiety is a structural feature found in a huge variety of biologically active metabolites. In recent times new insights into additional biosynthetic mechanisms, yielding in such six-membered unsaturated ester ring residues have been obtained. The purpose of this mini-review is to give a brief overview of α-pyrones and the mechanisms forming the basis of their natural synthesis. Especially the chain interconnecting enzymes, showing homology to ketosynthases which catalyze Claisen-like condensation reactions, will be presented.https://doi.org/10.3762/bjoc.12.56α-pyronesbiological activityinterconnecting ketosynthasesnatural productpolyketides |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Till F. Schäberle |
| spellingShingle |
Till F. Schäberle Biosynthesis of α-pyrones Beilstein Journal of Organic Chemistry α-pyrones biological activity interconnecting ketosynthases natural product polyketides |
| author_facet |
Till F. Schäberle |
| author_sort |
Till F. Schäberle |
| title |
Biosynthesis of α-pyrones |
| title_short |
Biosynthesis of α-pyrones |
| title_full |
Biosynthesis of α-pyrones |
| title_fullStr |
Biosynthesis of α-pyrones |
| title_full_unstemmed |
Biosynthesis of α-pyrones |
| title_sort |
biosynthesis of α-pyrones |
| publisher |
Beilstein-Institut |
| series |
Beilstein Journal of Organic Chemistry |
| issn |
1860-5397 |
| publishDate |
2016-03-01 |
| description |
The α-pyrone moiety is a structural feature found in a huge variety of biologically active metabolites. In recent times new insights into additional biosynthetic mechanisms, yielding in such six-membered unsaturated ester ring residues have been obtained. The purpose of this mini-review is to give a brief overview of α-pyrones and the mechanisms forming the basis of their natural synthesis. Especially the chain interconnecting enzymes, showing homology to ketosynthases which catalyze Claisen-like condensation reactions, will be presented. |
| topic |
α-pyrones biological activity interconnecting ketosynthases natural product polyketides |
| url |
https://doi.org/10.3762/bjoc.12.56 |
| work_keys_str_mv |
AT tillfschaberle biosynthesisofapyrones |
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1724297018040385536 |