Correlation of NSE and ProGRP levels in patients with small cell lung cancer before and after chemotherapy with cancer cell apoptosis caused by chemotherapy

• Main Authors: Wen-Yu Lu1, Xin-Min Zhou1, Hai-Ping Xu2
• Format: Article
• Language: English
• Published: Editorial Board of Journal of Hainan Medical University 2017-04-01
• Series: Journal of Hainan Medical University
• Subjects: Small cell lung cancer Neuron-specific enolase Pro-gastrin-releasing peptide Apoptosis Autophagy
• Online Access: http://www.hnykdxxb.com/PDF/201707/34.pdf
• ISSN: 1007-1237; 1007-1237

Objective: To study the correlation of NSE and ProGRP levels in patients with small cell lung cancer (SCLC) before and after chemotherapy with cancer cell apoptosis caused by chemotherapy. Methods: Patients with SCLC accepting EP chemotherapy in our hospital between August 2014 and October 2016 were selected, serum was collected before chemotherapy and after 3 cycles of chemotherapy respectively to determine NSE and ProGRP levels, the quartile of serum NSE and ProGRP levels after chemotherapy were referred to divide the patients into NSE and ProGRP-1 group, -2 group, -3 and -4 group from low to high; tumor lesions were collected to determine apoptosis molecule mRNA expression. Results: After chemotherapy, serum NSE and ProGRP levels of patients with SCLC were significantly lower than those before chemotherapy, and Fas, FasL, Caspase-8, Caspase-3, pULK and PI3KC3 mRNA expression in tumor lesion were significantly higher than those before chemotherapy; Fas, FasL, Caspase-8, Caspase-3, pULK and PI3KC3 mRNA expression in lesions of NSE and ProGRP-1 group, -2 group and -3 group were significantly higher than those of NSE and ProGRP-4 group, Fas, FasL, Caspase-8, Caspase-3, pULK and PI3KC3 mRNA expression in lesions of NSE and ProGRP-1 group and -2 group were significantly higher than those of NSE and ProGRP-3 group, and Fas, FasL, Caspase-8, Caspase-3, pULK and PI3KC3 mRNA expression in lesions of NSE and ProGRP-1 group were significantly higher than those of NSE and ProGRP-2 group. Conclusion: Serum NSE and ProGRP levels decrease significantly in patients with small cell lung cancer after chemotherapy, and they are closely related to the cancer cell apoptosis caused by chemotherapy.