NK/T-cell lymphoma of bilateral adrenal glands in a patient with pyothorax

• Main Authors: Tsukahara Tomohide, Takasawa Akira, Murata Masaki, Okumura Kazuyoshi, Nakayama Masato, Sato Noriyuki, Hasegawa Tadashi
• Format: Article
• Language: English
• Published: BMC 2012-08-01
• Series: Diagnostic Pathology
• Subjects: NK/T-cell lymphoma; Adrenal gland; EBV; Pyothorax; Autopsy
• Online Access: http://www.diagnosticpathology.org/content/7/1/114
• ISSN: 1746-1596

<p>Abstract</p> <p>Primary lymphoma of adrenal glands is rare, and non-B-cell lymphoma associated with pyothorax is also very rare. Here we report the first autopsy case of non-B-cell lymphoma in bilateral adrenal glands of a 79-year-old woman with pyothorax who had an aggressive clinical course. Immunohistochemically, tumor cells showed CD3+, CD45RO+, CD5-, CD7-, CD4-, CD8-, CD10-, CD20-, CD30-, CD79a-, CD138-, CD56-, granzyme B-, TIA-1+ and ALK-. In addition, tumor cells were strongly EBER1-positive by in situ hybridization. In genomic DNA of tumor cells, T-cell receptor rearrangements were not detected by southern blotting. We finally diagnosed this case as extranodal NK/T-cell lymphoma (nasal type).</p> <p>Virtual Slides</p> <p>The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/8050621197741854.</p>