Hemophagocytic macrophages harbor Salmonella enterica during persistent infection.
Salmonella enterica subspecies can establish persistent, systemic infections in mammals, including human typhoid fever. Persistent S. enterica disease is characterized by an initial acute infection that develops into an asymptomatic chronic infection. During both the acute and persistent stages, the...
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2007-12-01
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doaj-4771aa819a444706a12e806367fe71ad2020-11-25T01:35:06ZengPublic Library of Science (PLoS)PLoS Pathogens1553-73661553-73742007-12-01312e19310.1371/journal.ppat.0030193Hemophagocytic macrophages harbor Salmonella enterica during persistent infection.Rebecca N NixSarah E AltschulerPeter M HensonCorrella S DetweilerSalmonella enterica subspecies can establish persistent, systemic infections in mammals, including human typhoid fever. Persistent S. enterica disease is characterized by an initial acute infection that develops into an asymptomatic chronic infection. During both the acute and persistent stages, the bacteria generally reside within professional phagocytes, usually macrophages. It is unclear how salmonellae can survive within macrophages, cells that evolved, in part, to destroy pathogens. Evidence is presented that during the establishment of persistent murine infection, macrophages that contain S. enterica serotype Typhimurium are hemophagocytic. Hemophagocytic macrophages are characterized by the ingestion of non-apoptotic cells of the hematopoietic lineage and are a clinical marker of typhoid fever as well as certain other infectious and genetic diseases. Cell culture assays were developed to evaluate bacterial survival in hemophagocytic macrophages. S. Typhimurium preferentially replicated in macrophages that pre-phagocytosed viable cells, but the bacteria were killed in macrophages that pre-phagocytosed beads or dead cells. These data suggest that during persistent infection hemophagocytic macrophages may provide S. Typhimurium with a survival niche.http://europepmc.org/articles/PMC2134957?pdf=render |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Rebecca N Nix Sarah E Altschuler Peter M Henson Corrella S Detweiler |
spellingShingle |
Rebecca N Nix Sarah E Altschuler Peter M Henson Corrella S Detweiler Hemophagocytic macrophages harbor Salmonella enterica during persistent infection. PLoS Pathogens |
author_facet |
Rebecca N Nix Sarah E Altschuler Peter M Henson Corrella S Detweiler |
author_sort |
Rebecca N Nix |
title |
Hemophagocytic macrophages harbor Salmonella enterica during persistent infection. |
title_short |
Hemophagocytic macrophages harbor Salmonella enterica during persistent infection. |
title_full |
Hemophagocytic macrophages harbor Salmonella enterica during persistent infection. |
title_fullStr |
Hemophagocytic macrophages harbor Salmonella enterica during persistent infection. |
title_full_unstemmed |
Hemophagocytic macrophages harbor Salmonella enterica during persistent infection. |
title_sort |
hemophagocytic macrophages harbor salmonella enterica during persistent infection. |
publisher |
Public Library of Science (PLoS) |
series |
PLoS Pathogens |
issn |
1553-7366 1553-7374 |
publishDate |
2007-12-01 |
description |
Salmonella enterica subspecies can establish persistent, systemic infections in mammals, including human typhoid fever. Persistent S. enterica disease is characterized by an initial acute infection that develops into an asymptomatic chronic infection. During both the acute and persistent stages, the bacteria generally reside within professional phagocytes, usually macrophages. It is unclear how salmonellae can survive within macrophages, cells that evolved, in part, to destroy pathogens. Evidence is presented that during the establishment of persistent murine infection, macrophages that contain S. enterica serotype Typhimurium are hemophagocytic. Hemophagocytic macrophages are characterized by the ingestion of non-apoptotic cells of the hematopoietic lineage and are a clinical marker of typhoid fever as well as certain other infectious and genetic diseases. Cell culture assays were developed to evaluate bacterial survival in hemophagocytic macrophages. S. Typhimurium preferentially replicated in macrophages that pre-phagocytosed viable cells, but the bacteria were killed in macrophages that pre-phagocytosed beads or dead cells. These data suggest that during persistent infection hemophagocytic macrophages may provide S. Typhimurium with a survival niche. |
url |
http://europepmc.org/articles/PMC2134957?pdf=render |
work_keys_str_mv |
AT rebeccannix hemophagocyticmacrophagesharborsalmonellaentericaduringpersistentinfection AT sarahealtschuler hemophagocyticmacrophagesharborsalmonellaentericaduringpersistentinfection AT petermhenson hemophagocyticmacrophagesharborsalmonellaentericaduringpersistentinfection AT correllasdetweiler hemophagocyticmacrophagesharborsalmonellaentericaduringpersistentinfection |
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