Cisplatin Resistance in Osteosarcoma: In vitro Validation of Candidate DNA Repair-Related Therapeutic Targets and Drugs for Tailored Treatments

Cisplatin Resistance in Osteosarcoma: In vitro Validation of Candidate DNA Repair-Related Therapeutic Targets and Drugs for Tailored Treatments

Treatment of high-grade osteosarcoma, the most common malignant tumor of bone, is largely based on administration of cisplatin and other DNA damaging drugs. Altered DNA repair mechanisms may thus significantly impact on either response or resistance to chemotherapy. In this study, by using a panel o...

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Bibliographic Details
Main Authors: Marilù Fanelli, Elisa Tavanti, Maria Pia Patrizio, Serena Vella, Amira Fernandez-Ramos, Federica Magagnoli, Silvia Luppi, Claudia Maria Hattinger, Massimo Serra
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-03-01
Series:Frontiers in Oncology
Subjects:
osteosarcoma
DNA repair
cisplatin
drug resistance
chemotherapy
targeted drugs
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2020.00331/full

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