Correlation between VCAM-1, MIF and SFRP-5 content in plasma and renal impairment in patients with diabetic nephropathy

• Main Authors: Zhi Yang, Ji Zhang, Li-ping Tang
• Format: Article
• Language: English
• Published: Editorial Board of Journal of Hainan Medical University 2016-12-01
• Series: Journal of Hainan Medical University
• Subjects: Diabetic nephropathy; VCAM-1; MIF; SFRP-5; Renal function
• Online Access: http://www.hnykdxxb.com/PDF/201624/11.pdf
• ISSN: 1007-1237; 1007-1237

Objective: To analyze the correlation between VCAM-1, MIF and SFRP-5 content in plasma and renal impairment in patients with diabetic nephropathy. Methods: A total of 119 patients with type 2 diabetic nephropathy were selected as observation group and 100 healthy subjects were selected as control group. Differences in the content of VCAM-1, MIF and SFRP-5 in plasma, the content of renal function indexes, renal fibrosis indexes and oxidative stress indexes, etc. were compared between two groups of subjects. Results: VCAM-1 and MIF content in plasma of observation group were significantly higher than those of control group while SFRP-5 content was significantly lower than that of control group; β2-MG, Scr, UA and BUN content in plasma of observation group were higher than those of control group while Alb content and Ccr level were lower than those of control group; TIMP-1, TGF-β1, CⅣ, CTGF and Prolidase content in plasma of observation group were higher than those of control group; ROS, SOD, MDA and LHP content in plasma of observation group were higher than those of control group while GSH-PX and T-AOC content were lower than those of control group. VCAM-1, MIF and SFRP-5 content in plasma of patients with type 2 diabetic nephropathy were directly correlated with renal impairment indexes. Conclusions: VCAM-1, MIF and SFRP-5 content in plasma are the reliable indexes to judge the disease severity in patients with DN and are expected to provide basis for early screening and reasonable treatment of disease.