Correlation between VCAM-1, MIF and SFRP-5 content in plasma and renal impairment in patients with diabetic nephropathy
Objective: To analyze the correlation between VCAM-1, MIF and SFRP-5 content in plasma and renal impairment in patients with diabetic nephropathy. Methods: A total of 119 patients with type 2 diabetic nephropathy were selected as observation group and 100 healthy subjects were selected as control...
Main Authors: | , , |
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Format: | Article |
Language: | English |
Published: |
Editorial Board of Journal of Hainan Medical University
2016-12-01
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Series: | Journal of Hainan Medical University |
Subjects: | |
Online Access: | http://www.hnykdxxb.com/PDF/201624/11.pdf |
Summary: | Objective: To analyze the correlation between VCAM-1, MIF and SFRP-5 content in plasma
and renal impairment in patients with diabetic nephropathy. Methods: A total of 119 patients
with type 2 diabetic nephropathy were selected as observation group and 100 healthy subjects
were selected as control group. Differences in the content of VCAM-1, MIF and SFRP-5
in plasma, the content of renal function indexes, renal fibrosis indexes and oxidative stress
indexes, etc. were compared between two groups of subjects. Results: VCAM-1 and MIF
content in plasma of observation group were significantly higher than those of control group
while SFRP-5 content was significantly lower than that of control group; β2-MG, Scr, UA and
BUN content in plasma of observation group were higher than those of control group while Alb
content and Ccr level were lower than those of control group; TIMP-1, TGF-β1, CⅣ, CTGF
and Prolidase content in plasma of observation group were higher than those of control group;
ROS, SOD, MDA and LHP content in plasma of observation group were higher than those
of control group while GSH-PX and T-AOC content were lower than those of control group.
VCAM-1, MIF and SFRP-5 content in plasma of patients with type 2 diabetic nephropathy
were directly correlated with renal impairment indexes. Conclusions: VCAM-1, MIF and
SFRP-5 content in plasma are the reliable indexes to judge the disease severity in patients with
DN and are expected to provide basis for early screening and reasonable treatment of disease. |
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ISSN: | 1007-1237 1007-1237 |