Correlation between VCAM-1, MIF and SFRP-5 content in plasma and renal impairment in patients with diabetic nephropathy
Objective: To analyze the correlation between VCAM-1, MIF and SFRP-5 content in plasma and renal impairment in patients with diabetic nephropathy. Methods: A total of 119 patients with type 2 diabetic nephropathy were selected as observation group and 100 healthy subjects were selected as control...
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doaj-47770c05d5664010b3bd04232a95c4ef2020-11-24T21:30:38ZengEditorial Board of Journal of Hainan Medical UniversityJournal of Hainan Medical University1007-12371007-12372016-12-0122244245Correlation between VCAM-1, MIF and SFRP-5 content in plasma and renal impairment in patients with diabetic nephropathyZhi Yang0Ji Zhang1Li-ping Tang2Laboratory Department, Community Health Service Centre of Changzheng Town Putuo District Shanghai, Shanghai, 200333, ChinaLaboratory Department, Shanghai Putuo District People’s Hospital, Shanghai, 200333, ChinaBiochemical Laboratory, Shanghai Center for Clinical Laboratory, Shanghai, 200126, ChinaObjective: To analyze the correlation between VCAM-1, MIF and SFRP-5 content in plasma and renal impairment in patients with diabetic nephropathy. Methods: A total of 119 patients with type 2 diabetic nephropathy were selected as observation group and 100 healthy subjects were selected as control group. Differences in the content of VCAM-1, MIF and SFRP-5 in plasma, the content of renal function indexes, renal fibrosis indexes and oxidative stress indexes, etc. were compared between two groups of subjects. Results: VCAM-1 and MIF content in plasma of observation group were significantly higher than those of control group while SFRP-5 content was significantly lower than that of control group; β2-MG, Scr, UA and BUN content in plasma of observation group were higher than those of control group while Alb content and Ccr level were lower than those of control group; TIMP-1, TGF-β1, CⅣ, CTGF and Prolidase content in plasma of observation group were higher than those of control group; ROS, SOD, MDA and LHP content in plasma of observation group were higher than those of control group while GSH-PX and T-AOC content were lower than those of control group. VCAM-1, MIF and SFRP-5 content in plasma of patients with type 2 diabetic nephropathy were directly correlated with renal impairment indexes. Conclusions: VCAM-1, MIF and SFRP-5 content in plasma are the reliable indexes to judge the disease severity in patients with DN and are expected to provide basis for early screening and reasonable treatment of disease.http://www.hnykdxxb.com/PDF/201624/11.pdfDiabetic nephropathyVCAM-1MIFSFRP-5Renal function |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Zhi Yang Ji Zhang Li-ping Tang |
spellingShingle |
Zhi Yang Ji Zhang Li-ping Tang Correlation between VCAM-1, MIF and SFRP-5 content in plasma and renal impairment in patients with diabetic nephropathy Journal of Hainan Medical University Diabetic nephropathy VCAM-1 MIF SFRP-5 Renal function |
author_facet |
Zhi Yang Ji Zhang Li-ping Tang |
author_sort |
Zhi Yang |
title |
Correlation between VCAM-1, MIF and SFRP-5 content in plasma and renal impairment in patients with diabetic nephropathy |
title_short |
Correlation between VCAM-1, MIF and SFRP-5 content in plasma and renal impairment in patients with diabetic nephropathy |
title_full |
Correlation between VCAM-1, MIF and SFRP-5 content in plasma and renal impairment in patients with diabetic nephropathy |
title_fullStr |
Correlation between VCAM-1, MIF and SFRP-5 content in plasma and renal impairment in patients with diabetic nephropathy |
title_full_unstemmed |
Correlation between VCAM-1, MIF and SFRP-5 content in plasma and renal impairment in patients with diabetic nephropathy |
title_sort |
correlation between vcam-1, mif and sfrp-5 content in plasma and renal impairment in patients with diabetic nephropathy |
publisher |
Editorial Board of Journal of Hainan Medical University |
series |
Journal of Hainan Medical University |
issn |
1007-1237 1007-1237 |
publishDate |
2016-12-01 |
description |
Objective: To analyze the correlation between VCAM-1, MIF and SFRP-5 content in plasma
and renal impairment in patients with diabetic nephropathy. Methods: A total of 119 patients
with type 2 diabetic nephropathy were selected as observation group and 100 healthy subjects
were selected as control group. Differences in the content of VCAM-1, MIF and SFRP-5
in plasma, the content of renal function indexes, renal fibrosis indexes and oxidative stress
indexes, etc. were compared between two groups of subjects. Results: VCAM-1 and MIF
content in plasma of observation group were significantly higher than those of control group
while SFRP-5 content was significantly lower than that of control group; β2-MG, Scr, UA and
BUN content in plasma of observation group were higher than those of control group while Alb
content and Ccr level were lower than those of control group; TIMP-1, TGF-β1, CⅣ, CTGF
and Prolidase content in plasma of observation group were higher than those of control group;
ROS, SOD, MDA and LHP content in plasma of observation group were higher than those
of control group while GSH-PX and T-AOC content were lower than those of control group.
VCAM-1, MIF and SFRP-5 content in plasma of patients with type 2 diabetic nephropathy
were directly correlated with renal impairment indexes. Conclusions: VCAM-1, MIF and
SFRP-5 content in plasma are the reliable indexes to judge the disease severity in patients with
DN and are expected to provide basis for early screening and reasonable treatment of disease. |
topic |
Diabetic nephropathy VCAM-1 MIF SFRP-5 Renal function |
url |
http://www.hnykdxxb.com/PDF/201624/11.pdf |
work_keys_str_mv |
AT zhiyang correlationbetweenvcam1mifandsfrp5contentinplasmaandrenalimpairmentinpatientswithdiabeticnephropathy AT jizhang correlationbetweenvcam1mifandsfrp5contentinplasmaandrenalimpairmentinpatientswithdiabeticnephropathy AT lipingtang correlationbetweenvcam1mifandsfrp5contentinplasmaandrenalimpairmentinpatientswithdiabeticnephropathy |
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1725962451931889664 |