New Viral Facets in Oral Diseases: The EBV Paradox
The oral cavity contributes to overall health, psychosocial well-being and quality of human life. Oral inflammatory diseases represent a major global health problem with significant social and economic impact. The development of effective therapies, therefore, requires deeper insights into the etiop...
Main Authors: | , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2019-11-01
|
Series: | International Journal of Molecular Sciences |
Subjects: | |
Online Access: | https://www.mdpi.com/1422-0067/20/23/5861 |
id |
doaj-477995dddc71448fbea2aedf214df986 |
---|---|
record_format |
Article |
spelling |
doaj-477995dddc71448fbea2aedf214df9862020-11-25T00:39:42ZengMDPI AGInternational Journal of Molecular Sciences1422-00672019-11-012023586110.3390/ijms20235861ijms20235861New Viral Facets in Oral Diseases: The EBV ParadoxLilit Tonoyan0Séverine Vincent-Bugnas1Charles-Vivien Olivieri2Alain Doglio3Faculté de Chirurgie Dentaire, Université Côte d’Azur, EA 7354 MICORALIS (Microbiologie Orale, Immunothérapie et Santé), 06357 Nice, FranceFaculté de Chirurgie Dentaire, Université Côte d’Azur, EA 7354 MICORALIS (Microbiologie Orale, Immunothérapie et Santé), 06357 Nice, FranceFaculté de Chirurgie Dentaire, Université Côte d’Azur, EA 7354 MICORALIS (Microbiologie Orale, Immunothérapie et Santé), 06357 Nice, FranceFaculté de Chirurgie Dentaire, Université Côte d’Azur, EA 7354 MICORALIS (Microbiologie Orale, Immunothérapie et Santé), 06357 Nice, FranceThe oral cavity contributes to overall health, psychosocial well-being and quality of human life. Oral inflammatory diseases represent a major global health problem with significant social and economic impact. The development of effective therapies, therefore, requires deeper insights into the etiopathogenesis of oral diseases. Epstein−Barr virus (EBV) infection results in a life-long persistence of the virus in the host and has been associated with numerous oral inflammatory diseases including oral lichen planus (OLP), periodontal disease and Sjogren’s syndrome (SS). There is considerable evidence that the EBV infection is a strong risk factor for the development and progression of these conditions, but is EBV a true pathogen? This long-standing EBV paradox yet needs to be solved. This review discusses novel viral aspects of the etiopathogenesis of non-tumorigenic diseases in the oral cavity, in particular, the contribution of EBV in OLP, periodontitis and SS, the tropism of EBV infection, the major players involved in the etiopathogenic mechanisms and emerging contribution of EBV-pathogenic bacteria bidirectional interaction. It also proposes the involvement of EBV-infected plasma cells in the development and progression of oral inflammatory diseases. A new direction for preventing and treating these conditions may focus on controlling pathogenic EBV with anti-herpetic drugs.https://www.mdpi.com/1422-0067/20/23/5861epstein–barr viruslichen planus oralperiodontal diseasessjogren’s syndromeetiopathogenesis of oral inflammatory diseasesviral-bacterial synergismplasma cells |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Lilit Tonoyan Séverine Vincent-Bugnas Charles-Vivien Olivieri Alain Doglio |
spellingShingle |
Lilit Tonoyan Séverine Vincent-Bugnas Charles-Vivien Olivieri Alain Doglio New Viral Facets in Oral Diseases: The EBV Paradox International Journal of Molecular Sciences epstein–barr virus lichen planus oral periodontal diseases sjogren’s syndrome etiopathogenesis of oral inflammatory diseases viral-bacterial synergism plasma cells |
author_facet |
Lilit Tonoyan Séverine Vincent-Bugnas Charles-Vivien Olivieri Alain Doglio |
author_sort |
Lilit Tonoyan |
title |
New Viral Facets in Oral Diseases: The EBV Paradox |
title_short |
New Viral Facets in Oral Diseases: The EBV Paradox |
title_full |
New Viral Facets in Oral Diseases: The EBV Paradox |
title_fullStr |
New Viral Facets in Oral Diseases: The EBV Paradox |
title_full_unstemmed |
New Viral Facets in Oral Diseases: The EBV Paradox |
title_sort |
new viral facets in oral diseases: the ebv paradox |
publisher |
MDPI AG |
series |
International Journal of Molecular Sciences |
issn |
1422-0067 |
publishDate |
2019-11-01 |
description |
The oral cavity contributes to overall health, psychosocial well-being and quality of human life. Oral inflammatory diseases represent a major global health problem with significant social and economic impact. The development of effective therapies, therefore, requires deeper insights into the etiopathogenesis of oral diseases. Epstein−Barr virus (EBV) infection results in a life-long persistence of the virus in the host and has been associated with numerous oral inflammatory diseases including oral lichen planus (OLP), periodontal disease and Sjogren’s syndrome (SS). There is considerable evidence that the EBV infection is a strong risk factor for the development and progression of these conditions, but is EBV a true pathogen? This long-standing EBV paradox yet needs to be solved. This review discusses novel viral aspects of the etiopathogenesis of non-tumorigenic diseases in the oral cavity, in particular, the contribution of EBV in OLP, periodontitis and SS, the tropism of EBV infection, the major players involved in the etiopathogenic mechanisms and emerging contribution of EBV-pathogenic bacteria bidirectional interaction. It also proposes the involvement of EBV-infected plasma cells in the development and progression of oral inflammatory diseases. A new direction for preventing and treating these conditions may focus on controlling pathogenic EBV with anti-herpetic drugs. |
topic |
epstein–barr virus lichen planus oral periodontal diseases sjogren’s syndrome etiopathogenesis of oral inflammatory diseases viral-bacterial synergism plasma cells |
url |
https://www.mdpi.com/1422-0067/20/23/5861 |
work_keys_str_mv |
AT lilittonoyan newviralfacetsinoraldiseasestheebvparadox AT severinevincentbugnas newviralfacetsinoraldiseasestheebvparadox AT charlesvivienolivieri newviralfacetsinoraldiseasestheebvparadox AT alaindoglio newviralfacetsinoraldiseasestheebvparadox |
_version_ |
1725292952091099136 |