Improvement of myocardial perfusion reserve detected by cardiovascular magnetic resonance after direct endomyocardial implantation of autologous bone marrow cells in patients with severe coronary artery disease
<p>Abstract</p> <p>Background</p> <p>Recent studies suggested that bone marrow (BM) cell implantation in patients with severe chronic coronary artery disease (CAD) resulted in modest improvement in symptoms and cardiac function. This study sought to investigate the func...
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doaj-477d9aac926442c38950086ad1d7504c2020-11-24T21:33:53ZengBMCJournal of Cardiovascular Magnetic Resonance1097-66471532-429X2010-01-01121610.1186/1532-429X-12-6Improvement of myocardial perfusion reserve detected by cardiovascular magnetic resonance after direct endomyocardial implantation of autologous bone marrow cells in patients with severe coronary artery diseaseLau Chu-PakKwong Raymond YKwong Yok-LamChan CarmenTse Hung-Fat<p>Abstract</p> <p>Background</p> <p>Recent studies suggested that bone marrow (BM) cell implantation in patients with severe chronic coronary artery disease (CAD) resulted in modest improvement in symptoms and cardiac function. This study sought to investigate the functional changes that occur within the chronic human ischaemic myocardium after direct endomyocardial BM cells implantation by cardiovascular magnetic resonance (CMR).</p> <p>Methods and Results</p> <p>We compared the interval changes of left ventricular ejection fraction (LVEF), myocardial perfusion reserve and the extent of myocardial scar by using late gadolinium enhancement CMR in 12 patients with severe CAD. CMR was performed at baseline and at 6 months after catheter-based direct endomyocardial autologous BM cell (n = 12) injection to viable ischaemic myocardium as guided by electromechanical mapping. In patients randomized to receive BM cell injection, there was significant decrease in percentage area of peri-infarct regions (-23.6%, <it>P </it>= <it>0.04</it>) and increase in global LVEF (+9.0%, <it>P </it>= <it>0.02</it>), the percentage of regional wall thickening (+13.1%, <it>P= 0.04</it>) and MPR (+0.25%, <it>P </it>= <it>0.03</it>) over the target area at 6-months compared with baseline.</p> <p>Conclusions</p> <p>Direct endomyocardial implantation of autologous BM cells significantly improved global LVEF, regional wall thickening and myocardial perfusion reserve, and reduced percentage area of peri-infarct regions in patients with severe CAD.</p> http://www.jcmr-online.com/content/12/1/6 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Lau Chu-Pak Kwong Raymond Y Kwong Yok-Lam Chan Carmen Tse Hung-Fat |
spellingShingle |
Lau Chu-Pak Kwong Raymond Y Kwong Yok-Lam Chan Carmen Tse Hung-Fat Improvement of myocardial perfusion reserve detected by cardiovascular magnetic resonance after direct endomyocardial implantation of autologous bone marrow cells in patients with severe coronary artery disease Journal of Cardiovascular Magnetic Resonance |
author_facet |
Lau Chu-Pak Kwong Raymond Y Kwong Yok-Lam Chan Carmen Tse Hung-Fat |
author_sort |
Lau Chu-Pak |
title |
Improvement of myocardial perfusion reserve detected by cardiovascular magnetic resonance after direct endomyocardial implantation of autologous bone marrow cells in patients with severe coronary artery disease |
title_short |
Improvement of myocardial perfusion reserve detected by cardiovascular magnetic resonance after direct endomyocardial implantation of autologous bone marrow cells in patients with severe coronary artery disease |
title_full |
Improvement of myocardial perfusion reserve detected by cardiovascular magnetic resonance after direct endomyocardial implantation of autologous bone marrow cells in patients with severe coronary artery disease |
title_fullStr |
Improvement of myocardial perfusion reserve detected by cardiovascular magnetic resonance after direct endomyocardial implantation of autologous bone marrow cells in patients with severe coronary artery disease |
title_full_unstemmed |
Improvement of myocardial perfusion reserve detected by cardiovascular magnetic resonance after direct endomyocardial implantation of autologous bone marrow cells in patients with severe coronary artery disease |
title_sort |
improvement of myocardial perfusion reserve detected by cardiovascular magnetic resonance after direct endomyocardial implantation of autologous bone marrow cells in patients with severe coronary artery disease |
publisher |
BMC |
series |
Journal of Cardiovascular Magnetic Resonance |
issn |
1097-6647 1532-429X |
publishDate |
2010-01-01 |
description |
<p>Abstract</p> <p>Background</p> <p>Recent studies suggested that bone marrow (BM) cell implantation in patients with severe chronic coronary artery disease (CAD) resulted in modest improvement in symptoms and cardiac function. This study sought to investigate the functional changes that occur within the chronic human ischaemic myocardium after direct endomyocardial BM cells implantation by cardiovascular magnetic resonance (CMR).</p> <p>Methods and Results</p> <p>We compared the interval changes of left ventricular ejection fraction (LVEF), myocardial perfusion reserve and the extent of myocardial scar by using late gadolinium enhancement CMR in 12 patients with severe CAD. CMR was performed at baseline and at 6 months after catheter-based direct endomyocardial autologous BM cell (n = 12) injection to viable ischaemic myocardium as guided by electromechanical mapping. In patients randomized to receive BM cell injection, there was significant decrease in percentage area of peri-infarct regions (-23.6%, <it>P </it>= <it>0.04</it>) and increase in global LVEF (+9.0%, <it>P </it>= <it>0.02</it>), the percentage of regional wall thickening (+13.1%, <it>P= 0.04</it>) and MPR (+0.25%, <it>P </it>= <it>0.03</it>) over the target area at 6-months compared with baseline.</p> <p>Conclusions</p> <p>Direct endomyocardial implantation of autologous BM cells significantly improved global LVEF, regional wall thickening and myocardial perfusion reserve, and reduced percentage area of peri-infarct regions in patients with severe CAD.</p> |
url |
http://www.jcmr-online.com/content/12/1/6 |
work_keys_str_mv |
AT lauchupak improvementofmyocardialperfusionreservedetectedbycardiovascularmagneticresonanceafterdirectendomyocardialimplantationofautologousbonemarrowcellsinpatientswithseverecoronaryarterydisease AT kwongraymondy improvementofmyocardialperfusionreservedetectedbycardiovascularmagneticresonanceafterdirectendomyocardialimplantationofautologousbonemarrowcellsinpatientswithseverecoronaryarterydisease AT kwongyoklam improvementofmyocardialperfusionreservedetectedbycardiovascularmagneticresonanceafterdirectendomyocardialimplantationofautologousbonemarrowcellsinpatientswithseverecoronaryarterydisease AT chancarmen improvementofmyocardialperfusionreservedetectedbycardiovascularmagneticresonanceafterdirectendomyocardialimplantationofautologousbonemarrowcellsinpatientswithseverecoronaryarterydisease AT tsehungfat improvementofmyocardialperfusionreservedetectedbycardiovascularmagneticresonanceafterdirectendomyocardialimplantationofautologousbonemarrowcellsinpatientswithseverecoronaryarterydisease |
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