Phase I Clinical Study of the Dietary Supplement, Agaricus blazei Murill, in Cancer Patients in Remission
Although many cancer patients use complementary and alternative medicine, including Agaricus blazei Murill (ABM), safety is not yet well understood. Cancer survivors took 1.8, 3.6, or 5.4 g ABM granulated powder (Kyowa Wellness Co., Ltd., Tokyo, Japan) per day orally for 6 months. Adverse events wer...
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Online Access: | http://dx.doi.org/10.1155/2011/192381 |
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doaj-477eb5e639844cddac75080e693c443c2020-11-24T20:43:30ZengHindawi LimitedEvidence-Based Complementary and Alternative Medicine1741-427X1741-42882011-01-01201110.1155/2011/192381192381Phase I Clinical Study of the Dietary Supplement, Agaricus blazei Murill, in Cancer Patients in RemissionSatoshi Ohno0Yoshiteru Sumiyoshi1Katsuyoshi Hashine2Akitomi Shirato3Satoru Kyo4Masaki Inoue5Consolidated Research Institute for Advanced Science and Medical Care, Waseda University (ASMeW), 513 Wasedatsurumaki-cho, Shinjuku-ku, Tokyo 162-0041, JapanDepartment of Urology, Gengendo Kisarazu Clinic, 4737 Takayanagi, Kisarazu, Chiba 292-0014, JapanDepartment of Urology, Shikoku Cancer Center, 160 Ko, Minamiumemoto-machi, Matsuyama, Ehime 791-0280, JapanDepartment of Urology, Shikoku Cancer Center, 160 Ko, Minamiumemoto-machi, Matsuyama, Ehime 791-0280, JapanDepartment of Obstetrics and Gynecology, Graduate School of Medical Science, Kanazawa University, 13-1 Takaramachi, Kanazawa, Ishikawa 920-8640, JapanDepartment of Obstetrics and Gynecology, Graduate School of Medical Science, Kanazawa University, 13-1 Takaramachi, Kanazawa, Ishikawa 920-8640, JapanAlthough many cancer patients use complementary and alternative medicine, including Agaricus blazei Murill (ABM), safety is not yet well understood. Cancer survivors took 1.8, 3.6, or 5.4 g ABM granulated powder (Kyowa Wellness Co., Ltd., Tokyo, Japan) per day orally for 6 months. Adverse events were defined by subjective/objective symptoms and laboratory data according to the National Cancer Institute Common Terminology Criteria for Adverse Events version 3.0 (NCI-CTCAE v3.0). Seventy-eight patients were assessed for safety of ABM (30/24/24 subjects at 1/2/3 packs per day, resp.). Adverse events were observed in 9 patients (12%). Most were digestive in nature such as nausea and diarrhea, and one patient developed a liver dysfunction-related food allergy, drug lymphocyte product. However, none of these adverse events occurred in a dose-dependent manner. This study shows that ABM does not cause problems in most patients within laboratory parameters at the dosages tested over 6 months. This trial supports previous evidence that the ABM product is generally safe, excluding possible allergic reaction.http://dx.doi.org/10.1155/2011/192381 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Satoshi Ohno Yoshiteru Sumiyoshi Katsuyoshi Hashine Akitomi Shirato Satoru Kyo Masaki Inoue |
spellingShingle |
Satoshi Ohno Yoshiteru Sumiyoshi Katsuyoshi Hashine Akitomi Shirato Satoru Kyo Masaki Inoue Phase I Clinical Study of the Dietary Supplement, Agaricus blazei Murill, in Cancer Patients in Remission Evidence-Based Complementary and Alternative Medicine |
author_facet |
Satoshi Ohno Yoshiteru Sumiyoshi Katsuyoshi Hashine Akitomi Shirato Satoru Kyo Masaki Inoue |
author_sort |
Satoshi Ohno |
title |
Phase I Clinical Study of the Dietary Supplement, Agaricus blazei Murill, in Cancer Patients in Remission |
title_short |
Phase I Clinical Study of the Dietary Supplement, Agaricus blazei Murill, in Cancer Patients in Remission |
title_full |
Phase I Clinical Study of the Dietary Supplement, Agaricus blazei Murill, in Cancer Patients in Remission |
title_fullStr |
Phase I Clinical Study of the Dietary Supplement, Agaricus blazei Murill, in Cancer Patients in Remission |
title_full_unstemmed |
Phase I Clinical Study of the Dietary Supplement, Agaricus blazei Murill, in Cancer Patients in Remission |
title_sort |
phase i clinical study of the dietary supplement, agaricus blazei murill, in cancer patients in remission |
publisher |
Hindawi Limited |
series |
Evidence-Based Complementary and Alternative Medicine |
issn |
1741-427X 1741-4288 |
publishDate |
2011-01-01 |
description |
Although many cancer patients use complementary and alternative medicine, including Agaricus blazei Murill (ABM), safety is not yet well understood. Cancer survivors took 1.8, 3.6, or 5.4 g ABM granulated powder (Kyowa Wellness Co., Ltd., Tokyo, Japan) per day orally for 6 months. Adverse events were defined by subjective/objective symptoms and laboratory data according to the National Cancer Institute Common Terminology Criteria for Adverse Events version 3.0 (NCI-CTCAE v3.0). Seventy-eight patients were assessed for safety of ABM (30/24/24 subjects at 1/2/3 packs per day, resp.). Adverse events were observed in 9 patients (12%). Most were digestive in nature such as nausea and diarrhea, and one patient developed a liver dysfunction-related food allergy, drug lymphocyte product. However, none of these adverse events occurred in a dose-dependent manner. This study shows that ABM does not cause problems in most patients within laboratory parameters at the dosages tested over 6 months. This trial supports previous evidence that the ABM product is generally safe, excluding possible allergic reaction. |
url |
http://dx.doi.org/10.1155/2011/192381 |
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