Telomere damage induces internal loops that generate telomeric circles

Extrachromosomal circular DNA made of telomeric repeats have been found to have an effect on telomere maintenance. By combining electron microscopy with a telomere purification procedure the authors identify damage-induced i-loops as a key intermediate in telomere circle formation.

Bibliographic Details
Main Authors:	Giulia Mazzucco, Armela Huda, Martina Galli, Daniele Piccini, Michele Giannattasio, Fabio Pessina, Ylli Doksani
Format:	Article
Language:	English
Published:	Nature Publishing Group 2020-10-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-020-19139-4

id	doaj-4794b362fc0f49848c87e429d2bef503
record_format	Article
spelling	doaj-4794b362fc0f49848c87e429d2bef5032021-05-11T08:55:41ZengNature Publishing GroupNature Communications2041-17232020-10-0111111110.1038/s41467-020-19139-4Telomere damage induces internal loops that generate telomeric circlesGiulia Mazzucco0Armela Huda1Martina Galli2Daniele Piccini3Michele Giannattasio4Fabio Pessina5Ylli Doksani6IFOM, the FIRC Institute of Molecular OncologyIFOM, the FIRC Institute of Molecular OncologyIFOM, the FIRC Institute of Molecular OncologyIFOM, the FIRC Institute of Molecular OncologyIFOM, the FIRC Institute of Molecular OncologyIFOM, the FIRC Institute of Molecular OncologyIFOM, the FIRC Institute of Molecular OncologyExtrachromosomal circular DNA made of telomeric repeats have been found to have an effect on telomere maintenance. By combining electron microscopy with a telomere purification procedure the authors identify damage-induced i-loops as a key intermediate in telomere circle formation.https://doi.org/10.1038/s41467-020-19139-4
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Giulia Mazzucco Armela Huda Martina Galli Daniele Piccini Michele Giannattasio Fabio Pessina Ylli Doksani
spellingShingle	Giulia Mazzucco Armela Huda Martina Galli Daniele Piccini Michele Giannattasio Fabio Pessina Ylli Doksani Telomere damage induces internal loops that generate telomeric circles Nature Communications
author_facet	Giulia Mazzucco Armela Huda Martina Galli Daniele Piccini Michele Giannattasio Fabio Pessina Ylli Doksani
author_sort	Giulia Mazzucco
title	Telomere damage induces internal loops that generate telomeric circles
title_short	Telomere damage induces internal loops that generate telomeric circles
title_full	Telomere damage induces internal loops that generate telomeric circles
title_fullStr	Telomere damage induces internal loops that generate telomeric circles
title_full_unstemmed	Telomere damage induces internal loops that generate telomeric circles
title_sort	telomere damage induces internal loops that generate telomeric circles
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2020-10-01
description	Extrachromosomal circular DNA made of telomeric repeats have been found to have an effect on telomere maintenance. By combining electron microscopy with a telomere purification procedure the authors identify damage-induced i-loops as a key intermediate in telomere circle formation.
url	https://doi.org/10.1038/s41467-020-19139-4
work_keys_str_mv	AT giuliamazzucco telomeredamageinducesinternalloopsthatgeneratetelomericcircles AT armelahuda telomeredamageinducesinternalloopsthatgeneratetelomericcircles AT martinagalli telomeredamageinducesinternalloopsthatgeneratetelomericcircles AT danielepiccini telomeredamageinducesinternalloopsthatgeneratetelomericcircles AT michelegiannattasio telomeredamageinducesinternalloopsthatgeneratetelomericcircles AT fabiopessina telomeredamageinducesinternalloopsthatgeneratetelomericcircles AT yllidoksani telomeredamageinducesinternalloopsthatgeneratetelomericcircles
_version_	1721450307399974912

Telomere damage induces internal loops that generate telomeric circles

Similar Items