The Koala Immune Response to Chlamydial Infection and Vaccine Development—Advancing Our Immunological Understanding
<i>Chlamydia</i> is a significant pathogen for many species, including the much-loved Australian marsupial, the koala (<i>Phascolarctos cinereus</i>). To combat this situation, focused research has gone into the development and refinement of a chlamydial vaccine for koalas. T...
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doaj-47a80f3522794d118bd4f63a51c72c592021-02-04T00:00:17ZengMDPI AGAnimals2076-26152021-02-011138038010.3390/ani11020380The Koala Immune Response to Chlamydial Infection and Vaccine Development—Advancing Our Immunological UnderstandingBonnie L Quigley0Peter Timms1Provectus Algae, Noosaville, QLD 4566, AustraliaGenecology Research Centre, University of the Sunshine Coast, Sippy Downs, QLD 4556, Australia<i>Chlamydia</i> is a significant pathogen for many species, including the much-loved Australian marsupial, the koala (<i>Phascolarctos cinereus</i>). To combat this situation, focused research has gone into the development and refinement of a chlamydial vaccine for koalas. The foundation of this process has involved characterising the immune response of koalas to both natural chlamydial infection as well as vaccination. From parallels in human and mouse research, it is well-established that an effective anti-chlamydial response will involve a balance of cell-mediated Th1 responses involving interferon-gamma (IFN-γ), humoral Th2 responses involving systemic IgG and mucosal IgA, and inflammatory Th17 responses involving interleukin 17 (IL-17) and neutrophils. Characterisation of koalas with chlamydial disease has shown increased expression within all three of these major immunological pathways and monitoring of koalas’ post-vaccination has detected further enhancements to these key pathways. These findings offer optimism that a chlamydial vaccine for wider distribution to koalas is not far off. Recent advances in marsupial genetic knowledge and general nucleic acid assay technology have moved koala immunological research a step closer to other mammalian research systems. However, koala-specific reagents to directly assay cytokine levels and cell-surface markers are still needed to progress our understanding of koala immunology.https://www.mdpi.com/2076-2615/11/2/380koalasvaccinesimmunity<i>Chlamydia</i> |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Bonnie L Quigley Peter Timms |
spellingShingle |
Bonnie L Quigley Peter Timms The Koala Immune Response to Chlamydial Infection and Vaccine Development—Advancing Our Immunological Understanding Animals koalas vaccines immunity <i>Chlamydia</i> |
author_facet |
Bonnie L Quigley Peter Timms |
author_sort |
Bonnie L Quigley |
title |
The Koala Immune Response to Chlamydial Infection and Vaccine Development—Advancing Our Immunological Understanding |
title_short |
The Koala Immune Response to Chlamydial Infection and Vaccine Development—Advancing Our Immunological Understanding |
title_full |
The Koala Immune Response to Chlamydial Infection and Vaccine Development—Advancing Our Immunological Understanding |
title_fullStr |
The Koala Immune Response to Chlamydial Infection and Vaccine Development—Advancing Our Immunological Understanding |
title_full_unstemmed |
The Koala Immune Response to Chlamydial Infection and Vaccine Development—Advancing Our Immunological Understanding |
title_sort |
koala immune response to chlamydial infection and vaccine development—advancing our immunological understanding |
publisher |
MDPI AG |
series |
Animals |
issn |
2076-2615 |
publishDate |
2021-02-01 |
description |
<i>Chlamydia</i> is a significant pathogen for many species, including the much-loved Australian marsupial, the koala (<i>Phascolarctos cinereus</i>). To combat this situation, focused research has gone into the development and refinement of a chlamydial vaccine for koalas. The foundation of this process has involved characterising the immune response of koalas to both natural chlamydial infection as well as vaccination. From parallels in human and mouse research, it is well-established that an effective anti-chlamydial response will involve a balance of cell-mediated Th1 responses involving interferon-gamma (IFN-γ), humoral Th2 responses involving systemic IgG and mucosal IgA, and inflammatory Th17 responses involving interleukin 17 (IL-17) and neutrophils. Characterisation of koalas with chlamydial disease has shown increased expression within all three of these major immunological pathways and monitoring of koalas’ post-vaccination has detected further enhancements to these key pathways. These findings offer optimism that a chlamydial vaccine for wider distribution to koalas is not far off. Recent advances in marsupial genetic knowledge and general nucleic acid assay technology have moved koala immunological research a step closer to other mammalian research systems. However, koala-specific reagents to directly assay cytokine levels and cell-surface markers are still needed to progress our understanding of koala immunology. |
topic |
koalas vaccines immunity <i>Chlamydia</i> |
url |
https://www.mdpi.com/2076-2615/11/2/380 |
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