Molecular characterization of macrolide resistance of a Mycoplasma pneumoniae strain that developed during therapy of a patient with pneumonia

Molecular characterization of macrolide resistance of a Mycoplasma pneumoniae strain that developed during therapy of a patient with pneumonia

The development of macrolide resistance that occurred during 3 days of therapy with azithromycin to treat Mycoplasma pneumoniae pneumonia in a paediatric patient is reported. After extended molecular characterization of strains, the parallel occurrence of clones showing the non-mutated wild-type 23...

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Bibliographic Details
Main Authors: Roger Dumke, Simone Stolz, Enno Jacobs, Thomas Juretzek
Format: Article
Language:English
Published: Elsevier 2014-12-01
Series:International Journal of Infectious Diseases
Subjects:
Community-acquired pneumonia
Mycoplasma pneumoniae
Typing Macrolide resistance
Online Access:http://www.sciencedirect.com/science/article/pii/S1201971214015999
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spelling doaj-47ac2ee310064c57a32d974293d2aa0c2020-11-24T22:49:13ZengElsevierInternational Journal of Infectious Diseases1201-97121878-35112014-12-0129C19719910.1016/j.ijid.2014.07.014Molecular characterization of macrolide resistance of a Mycoplasma pneumoniae strain that developed during therapy of a patient with pneumoniaRoger Dumke0Simone Stolz1Enno Jacobs2Thomas Juretzek3TU Dresden, Medizinische Fakultät Carl Gustav Carus, Institut für Medizinische Mikrobiologie und Hygiene, Fetscherstrasse 74, 01307 Dresden, GermanyKlinik für Kinder- und Jugendmedizin, Carl-Thiem-Klinikum gGmbH, Cottbus, GermanyTU Dresden, Medizinische Fakultät Carl Gustav Carus, Institut für Medizinische Mikrobiologie und Hygiene, Fetscherstrasse 74, 01307 Dresden, GermanyInstitut für Mikrobiologie und Krankenhaushygiene, Carl-Thiem-Klinikum gGmbH, Cottbus, Germany The development of macrolide resistance that occurred during 3 days of therapy with azithromycin to treat Mycoplasma pneumoniae pneumonia in a paediatric patient is reported. After extended molecular characterization of strains, the parallel occurrence of clones showing the non-mutated wild-type 23S rRNA sequence as well as mutations A2063G and A2064G, which are both responsible for phenotypic resistance, was confirmed for the first time. http://www.sciencedirect.com/science/article/pii/S1201971214015999Community-acquired pneumoniaMycoplasma pneumoniaeTyping Macrolide resistance
collection DOAJ
language English
format Article
sources DOAJ
author Roger Dumke
Simone Stolz
Enno Jacobs
Thomas Juretzek
spellingShingle Roger Dumke
Simone Stolz
Enno Jacobs
Thomas Juretzek
Molecular characterization of macrolide resistance of a Mycoplasma pneumoniae strain that developed during therapy of a patient with pneumonia
International Journal of Infectious Diseases
Community-acquired pneumonia
Mycoplasma pneumoniae
Typing Macrolide resistance
author_facet Roger Dumke
Simone Stolz
Enno Jacobs
Thomas Juretzek
author_sort Roger Dumke
title Molecular characterization of macrolide resistance of a Mycoplasma pneumoniae strain that developed during therapy of a patient with pneumonia
title_short Molecular characterization of macrolide resistance of a Mycoplasma pneumoniae strain that developed during therapy of a patient with pneumonia
title_full Molecular characterization of macrolide resistance of a Mycoplasma pneumoniae strain that developed during therapy of a patient with pneumonia
title_fullStr Molecular characterization of macrolide resistance of a Mycoplasma pneumoniae strain that developed during therapy of a patient with pneumonia
title_full_unstemmed Molecular characterization of macrolide resistance of a Mycoplasma pneumoniae strain that developed during therapy of a patient with pneumonia
title_sort molecular characterization of macrolide resistance of a mycoplasma pneumoniae strain that developed during therapy of a patient with pneumonia
publisher Elsevier
series International Journal of Infectious Diseases
issn 1201-9712
1878-3511
publishDate 2014-12-01
description The development of macrolide resistance that occurred during 3 days of therapy with azithromycin to treat Mycoplasma pneumoniae pneumonia in a paediatric patient is reported. After extended molecular characterization of strains, the parallel occurrence of clones showing the non-mutated wild-type 23S rRNA sequence as well as mutations A2063G and A2064G, which are both responsible for phenotypic resistance, was confirmed for the first time.
topic Community-acquired pneumonia
Mycoplasma pneumoniae
Typing Macrolide resistance
url http://www.sciencedirect.com/science/article/pii/S1201971214015999
work_keys_str_mv AT rogerdumke molecularcharacterizationofmacrolideresistanceofamycoplasmapneumoniaestrainthatdevelopedduringtherapyofapatientwithpneumonia
AT simonestolz molecularcharacterizationofmacrolideresistanceofamycoplasmapneumoniaestrainthatdevelopedduringtherapyofapatientwithpneumonia
AT ennojacobs molecularcharacterizationofmacrolideresistanceofamycoplasmapneumoniaestrainthatdevelopedduringtherapyofapatientwithpneumonia
AT thomasjuretzek molecularcharacterizationofmacrolideresistanceofamycoplasmapneumoniaestrainthatdevelopedduringtherapyofapatientwithpneumonia
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