A study of cardiac autonomic neuropathy in patients with type 2 diabetes mellitus: A Northeast India experience
Aim: To investigate the prevalence and the risk factors for cardiac autonomic neuropathy (CAN) in type 2 diabetes mellitus (DM) patients. Study Design: Cross-sectional cohort study. Place and Duration of Study: This study was conducted in the Department of Endocrinology, Gauhati Medical College and...
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doaj-47b14c4dc1154372b733dc6aa813e91e2020-11-25T01:01:27ZengWolters Kluwer Medknow PublicationsIndian Journal of Endocrinology and Metabolism2230-82102019-01-0123224625010.4103/ijem.IJEM_336_18A study of cardiac autonomic neuropathy in patients with type 2 diabetes mellitus: A Northeast India experienceAshok K BhuyanAbhamoni BaroDipti SarmaBipul ChoudhuryAim: To investigate the prevalence and the risk factors for cardiac autonomic neuropathy (CAN) in type 2 diabetes mellitus (DM) patients. Study Design: Cross-sectional cohort study. Place and Duration of Study: This study was conducted in the Department of Endocrinology, Gauhati Medical College and Hospital, Assam, India between December 2016 to March 2018. Methodology: We included 100 patients (60 males and 40 females; age range: 36–72 years) with type 2 DM. Their clinical, biochemical, and metabolic parameters were analyzed and assessment of CAN were done based on the Ewing's criteria. Results: Out of 100 patients, 60 were males and 40 were females. The mean age of the patients was 53.3 ± 10.37 years (36–72 years) and the mean duration of diabetes was 9.03 ± 6.4 years (6 months–25 years). Patients were divided into two groups: “without CAN” (CAN−) and “with CAN” (CAN+). The prevalence of CAN was 70%, with early CAN in 25%, definite CAN in 24%, and severe CAN in 21% cases The patients with CAN were older (P = 0.0005), had longer diabetes duration (11.56 vs. 3.13; P = 0.0001), higher creatinine (P < 0.0001), and lower estimated glomerular filtration rate (eGFR) (P = 0.0001) compared to patients without CAN. Retinopathy, peripheral neuropathy, and nephropathy were common in CAN + patients. On multiple logistic regression analysis, duration of diabetes [odds ratio (OR); 6.7, P < 0.0001), older age (OR; 1.07, P < 0.016), and lower eGFR (OR; 0.97, P < 0.03) were risk factors for CAN. Conclusion: CAN is a common microvascular complication in type 2 DM with duration of diabetes, age, and severity of nephropathy being its significant determinants.http://www.ijem.in/article.asp?issn=2230-8210;year=2019;volume=23;issue=2;spage=246;epage=250;aulast=BhuyanCardiac autonomic neuropathycomplicationIndiatype 2 diabetes mellitus |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ashok K Bhuyan Abhamoni Baro Dipti Sarma Bipul Choudhury |
spellingShingle |
Ashok K Bhuyan Abhamoni Baro Dipti Sarma Bipul Choudhury A study of cardiac autonomic neuropathy in patients with type 2 diabetes mellitus: A Northeast India experience Indian Journal of Endocrinology and Metabolism Cardiac autonomic neuropathy complication India type 2 diabetes mellitus |
author_facet |
Ashok K Bhuyan Abhamoni Baro Dipti Sarma Bipul Choudhury |
author_sort |
Ashok K Bhuyan |
title |
A study of cardiac autonomic neuropathy in patients with type 2 diabetes mellitus: A Northeast India experience |
title_short |
A study of cardiac autonomic neuropathy in patients with type 2 diabetes mellitus: A Northeast India experience |
title_full |
A study of cardiac autonomic neuropathy in patients with type 2 diabetes mellitus: A Northeast India experience |
title_fullStr |
A study of cardiac autonomic neuropathy in patients with type 2 diabetes mellitus: A Northeast India experience |
title_full_unstemmed |
A study of cardiac autonomic neuropathy in patients with type 2 diabetes mellitus: A Northeast India experience |
title_sort |
study of cardiac autonomic neuropathy in patients with type 2 diabetes mellitus: a northeast india experience |
publisher |
Wolters Kluwer Medknow Publications |
series |
Indian Journal of Endocrinology and Metabolism |
issn |
2230-8210 |
publishDate |
2019-01-01 |
description |
Aim: To investigate the prevalence and the risk factors for cardiac autonomic neuropathy (CAN) in type 2 diabetes mellitus (DM) patients. Study Design: Cross-sectional cohort study. Place and Duration of Study: This study was conducted in the Department of Endocrinology, Gauhati Medical College and Hospital, Assam, India between December 2016 to March 2018. Methodology: We included 100 patients (60 males and 40 females; age range: 36–72 years) with type 2 DM. Their clinical, biochemical, and metabolic parameters were analyzed and assessment of CAN were done based on the Ewing's criteria. Results: Out of 100 patients, 60 were males and 40 were females. The mean age of the patients was 53.3 ± 10.37 years (36–72 years) and the mean duration of diabetes was 9.03 ± 6.4 years (6 months–25 years). Patients were divided into two groups: “without CAN” (CAN−) and “with CAN” (CAN+). The prevalence of CAN was 70%, with early CAN in 25%, definite CAN in 24%, and severe CAN in 21% cases The patients with CAN were older (P = 0.0005), had longer diabetes duration (11.56 vs. 3.13; P = 0.0001), higher creatinine (P < 0.0001), and lower estimated glomerular filtration rate (eGFR) (P = 0.0001) compared to patients without CAN. Retinopathy, peripheral neuropathy, and nephropathy were common in CAN + patients. On multiple logistic regression analysis, duration of diabetes [odds ratio (OR); 6.7, P < 0.0001), older age (OR; 1.07, P < 0.016), and lower eGFR (OR; 0.97, P < 0.03) were risk factors for CAN. Conclusion: CAN is a common microvascular complication in type 2 DM with duration of diabetes, age, and severity of nephropathy being its significant determinants. |
topic |
Cardiac autonomic neuropathy complication India type 2 diabetes mellitus |
url |
http://www.ijem.in/article.asp?issn=2230-8210;year=2019;volume=23;issue=2;spage=246;epage=250;aulast=Bhuyan |
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