Identification of recurrent FHL2-GLI2 oncogenic fusion in sclerosing stromal tumors of the ovary
Little is known about the genetics of sclerosing stromal tumor of the ovary, a rare type of sex cord-stromal tumor. Here, the authors use sequencing strategies to show that in a cohort of 26 tumor samples 65% carry a FHL2-GLI2 fusion gene and demonstrate in vitro that the fusion gene has oncogenic p...
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2020-01-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-019-13806-x |
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doaj-47b2a974b2b14385a7cca2142adfd91e2021-05-11T08:01:51ZengNature Publishing GroupNature Communications2041-17232020-01-0111111610.1038/s41467-019-13806-xIdentification of recurrent FHL2-GLI2 oncogenic fusion in sclerosing stromal tumors of the ovarySarah H. Kim0Arnaud Da Cruz Paula1Thais Basili2Higinio Dopeso3Rui Bi4Fresia Pareja5Edaise M. da Silva6Rodrigo Gularte-Mérida7Zhen Sun8Sho Fujisawa9Caitlin G. Smith10Lorenzo Ferrando11Ana Paula Martins Sebastião12Yonina Bykov13Anqi Li14Catarina Silveira15Charles W. Ashley16Anthe Stylianou17Pier Selenica18Wesley R. Samore19Achim A. Jungbluth20Dmitriy Zamarin21Nadeem R. Abu-Rustum22Kristian Helin23Robert A. Soslow24Jorge S. Reis-Filho25Esther Oliva26Britta Weigelt27Department of Surgery, Memorial Sloan Kettering Cancer CenterDepartment of Surgery, Memorial Sloan Kettering Cancer CenterDepartment of Pathology, Memorial Sloan Kettering Cancer CenterDepartment of Pathology, Memorial Sloan Kettering Cancer CenterDepartment of Pathology, Memorial Sloan Kettering Cancer CenterDepartment of Pathology, Memorial Sloan Kettering Cancer CenterDepartment of Pathology, Memorial Sloan Kettering Cancer CenterDepartment of Surgery, Memorial Sloan Kettering Cancer CenterCell Biology Program and Center for Epigenetics, Memorial Sloan Kettering Cancer CenterMolecular Cytology Core Facility, Memorial Sloan Kettering Cancer CenterDepartment of Pathology, Memorial Sloan Kettering Cancer CenterDepartment of Pathology, Memorial Sloan Kettering Cancer CenterDepartment of Pathology, Memorial Sloan Kettering Cancer CenterDepartment of Medicine, Memorial Sloan Kettering Cancer CenterDepartment of Pathology, Memorial Sloan Kettering Cancer CenterDepartment of Pathology, Memorial Sloan Kettering Cancer CenterDepartment of Surgery, Memorial Sloan Kettering Cancer CenterDepartment of Surgery, Memorial Sloan Kettering Cancer CenterDepartment of Pathology, Memorial Sloan Kettering Cancer CenterDepartment of Pathology, Massachusetts General Hospital, Harvard Medical SchoolDepartment of Pathology, Memorial Sloan Kettering Cancer CenterDepartment of Medicine, Memorial Sloan Kettering Cancer CenterDepartment of Surgery, Memorial Sloan Kettering Cancer CenterCell Biology Program and Center for Epigenetics, Memorial Sloan Kettering Cancer CenterDepartment of Pathology, Memorial Sloan Kettering Cancer CenterDepartment of Pathology, Memorial Sloan Kettering Cancer CenterDepartment of Pathology, Massachusetts General Hospital, Harvard Medical SchoolDepartment of Pathology, Memorial Sloan Kettering Cancer CenterLittle is known about the genetics of sclerosing stromal tumor of the ovary, a rare type of sex cord-stromal tumor. Here, the authors use sequencing strategies to show that in a cohort of 26 tumor samples 65% carry a FHL2-GLI2 fusion gene and demonstrate in vitro that the fusion gene has oncogenic properties.https://doi.org/10.1038/s41467-019-13806-x |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Sarah H. Kim Arnaud Da Cruz Paula Thais Basili Higinio Dopeso Rui Bi Fresia Pareja Edaise M. da Silva Rodrigo Gularte-Mérida Zhen Sun Sho Fujisawa Caitlin G. Smith Lorenzo Ferrando Ana Paula Martins Sebastião Yonina Bykov Anqi Li Catarina Silveira Charles W. Ashley Anthe Stylianou Pier Selenica Wesley R. Samore Achim A. Jungbluth Dmitriy Zamarin Nadeem R. Abu-Rustum Kristian Helin Robert A. Soslow Jorge S. Reis-Filho Esther Oliva Britta Weigelt |
| spellingShingle |
Sarah H. Kim Arnaud Da Cruz Paula Thais Basili Higinio Dopeso Rui Bi Fresia Pareja Edaise M. da Silva Rodrigo Gularte-Mérida Zhen Sun Sho Fujisawa Caitlin G. Smith Lorenzo Ferrando Ana Paula Martins Sebastião Yonina Bykov Anqi Li Catarina Silveira Charles W. Ashley Anthe Stylianou Pier Selenica Wesley R. Samore Achim A. Jungbluth Dmitriy Zamarin Nadeem R. Abu-Rustum Kristian Helin Robert A. Soslow Jorge S. Reis-Filho Esther Oliva Britta Weigelt Identification of recurrent FHL2-GLI2 oncogenic fusion in sclerosing stromal tumors of the ovary Nature Communications |
| author_facet |
Sarah H. Kim Arnaud Da Cruz Paula Thais Basili Higinio Dopeso Rui Bi Fresia Pareja Edaise M. da Silva Rodrigo Gularte-Mérida Zhen Sun Sho Fujisawa Caitlin G. Smith Lorenzo Ferrando Ana Paula Martins Sebastião Yonina Bykov Anqi Li Catarina Silveira Charles W. Ashley Anthe Stylianou Pier Selenica Wesley R. Samore Achim A. Jungbluth Dmitriy Zamarin Nadeem R. Abu-Rustum Kristian Helin Robert A. Soslow Jorge S. Reis-Filho Esther Oliva Britta Weigelt |
| author_sort |
Sarah H. Kim |
| title |
Identification of recurrent FHL2-GLI2 oncogenic fusion in sclerosing stromal tumors of the ovary |
| title_short |
Identification of recurrent FHL2-GLI2 oncogenic fusion in sclerosing stromal tumors of the ovary |
| title_full |
Identification of recurrent FHL2-GLI2 oncogenic fusion in sclerosing stromal tumors of the ovary |
| title_fullStr |
Identification of recurrent FHL2-GLI2 oncogenic fusion in sclerosing stromal tumors of the ovary |
| title_full_unstemmed |
Identification of recurrent FHL2-GLI2 oncogenic fusion in sclerosing stromal tumors of the ovary |
| title_sort |
identification of recurrent fhl2-gli2 oncogenic fusion in sclerosing stromal tumors of the ovary |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2020-01-01 |
| description |
Little is known about the genetics of sclerosing stromal tumor of the ovary, a rare type of sex cord-stromal tumor. Here, the authors use sequencing strategies to show that in a cohort of 26 tumor samples 65% carry a FHL2-GLI2 fusion gene and demonstrate in vitro that the fusion gene has oncogenic properties. |
| url |
https://doi.org/10.1038/s41467-019-13806-x |
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