Advances and Insights of APC-Asef Inhibitors for Metastatic Colorectal Cancer Therapy

Advances and Insights of APC-Asef Inhibitors for Metastatic Colorectal Cancer Therapy

In Colorectal cancer (CRC), adenomatous polyposis coli (APC) directly interacts with the Rho guanine nucleotide exchange factor 4 (Asef) and releases its GEF activity. Activated Asef promotes the aberrant migration and invasion of CRC cell through a CDC42-mediated pathway. Knockdown of either APC or...

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Bibliographic Details
Main Authors:	Xiuyan Yang, Jie Zhong, Qiufen Zhang, Li Feng, Zhen Zheng, Jian Zhang, Shaoyong Lu
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2021-04-01
Series:	Frontiers in Molecular Biosciences
Subjects:	APC-Asef inhibitors structure based drug design peptide inhibitors small molecule inhibitors colorectal cancer therapy
Online Access:	https://www.frontiersin.org/articles/10.3389/fmolb.2021.662579/full

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