Angiotensin- Converting Enzyme Insertion/Deletion Polymorphism and Its Association with Coronary Artery Disease in an Iranian Population
Background: The study of the association between genotype and phenotype is of great importance for the prediction of many diseases and pathophysiological conditions. The relationship between angiotensin-converting enzyme (ACE) gene insertion/ deletion (I/D) polymorphism and pathological processe...
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Tehran University of Medical Sciences
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doaj-47d9373a94c44202a51bd0e19f23314b2020-11-25T04:05:19ZengTehran University of Medical SciencesJournal of Tehran University Heart Center1735-86202008-23712015-10-0182284Angiotensin- Converting Enzyme Insertion/Deletion Polymorphism and Its Association with Coronary Artery Disease in an Iranian PopulationLeila Poorgholi0Hana Saffar1Mahmood Sheikh-Fathollahi2Gholamreza Davoodi3Maryam Sotoudeh-Anvari4Hamidreza Goodarzynejad5Shayan Ziaee6MohammadAli Boroumand7Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran.Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran.Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran.Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran.Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran.Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran.Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran.Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran. Background: The study of the association between genotype and phenotype is of great importance for the prediction of many diseases and pathophysiological conditions. The relationship between angiotensin-converting enzyme (ACE) gene insertion/ deletion (I/D) polymorphism and pathological processes such as coronary artery disease (CAD) has been investigated previously with discordant results. This study was designed to determine the association between ACE gene I/D polymorphism and CAD in an Iranian population. Methods: A total of 1050 individuals who were referred to Tehran Heart Center for coronary angiography were recruited. Six hundred seventy-six CAD-positive patients (documented by coronary angiography and Gensini scores higher than 6) and 374 CAD-negative patients were evaluated for ACE gene I/D polymorphism via the Polymerase Chain Reaction Amplification method. The patients’ age, sex, smoking status and its duration as well as familial history of CAD, hypertension, and diabetes mellitus were recorded. Results: Five hundred four (74.6%) of the CAD-positive patients were male, and the mean age of this group was 60 (60 ±10). In the CAD-negative individuals, the mean age was 56 (56 ± 10) and 196 of them were male (52.4%). After the analysis of all the groups and gender subgroups, neither genotype nor allele frequency was significantly different between the CAD- positive and CAD-negative groups (p values for genotypes and allele frequencies were 0.494 and 0.397, respectively). Conclusion: ACE gene I/D polymorphism was not associated with an increased risk of CAD in an Iranian population. https://jthc.tums.ac.ir/index.php/jthc/article/view/288Coronary artery disease • Polymorphismgenetic • Iran |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Leila Poorgholi Hana Saffar Mahmood Sheikh-Fathollahi Gholamreza Davoodi Maryam Sotoudeh-Anvari Hamidreza Goodarzynejad Shayan Ziaee MohammadAli Boroumand |
spellingShingle |
Leila Poorgholi Hana Saffar Mahmood Sheikh-Fathollahi Gholamreza Davoodi Maryam Sotoudeh-Anvari Hamidreza Goodarzynejad Shayan Ziaee MohammadAli Boroumand Angiotensin- Converting Enzyme Insertion/Deletion Polymorphism and Its Association with Coronary Artery Disease in an Iranian Population Journal of Tehran University Heart Center Coronary artery disease • Polymorphism genetic • Iran |
author_facet |
Leila Poorgholi Hana Saffar Mahmood Sheikh-Fathollahi Gholamreza Davoodi Maryam Sotoudeh-Anvari Hamidreza Goodarzynejad Shayan Ziaee MohammadAli Boroumand |
author_sort |
Leila Poorgholi |
title |
Angiotensin- Converting Enzyme Insertion/Deletion Polymorphism and Its Association with Coronary Artery Disease in an Iranian Population |
title_short |
Angiotensin- Converting Enzyme Insertion/Deletion Polymorphism and Its Association with Coronary Artery Disease in an Iranian Population |
title_full |
Angiotensin- Converting Enzyme Insertion/Deletion Polymorphism and Its Association with Coronary Artery Disease in an Iranian Population |
title_fullStr |
Angiotensin- Converting Enzyme Insertion/Deletion Polymorphism and Its Association with Coronary Artery Disease in an Iranian Population |
title_full_unstemmed |
Angiotensin- Converting Enzyme Insertion/Deletion Polymorphism and Its Association with Coronary Artery Disease in an Iranian Population |
title_sort |
angiotensin- converting enzyme insertion/deletion polymorphism and its association with coronary artery disease in an iranian population |
publisher |
Tehran University of Medical Sciences |
series |
Journal of Tehran University Heart Center |
issn |
1735-8620 2008-2371 |
publishDate |
2015-10-01 |
description |
Background: The study of the association between genotype and phenotype is of great importance for the prediction of many diseases and pathophysiological conditions. The relationship between angiotensin-converting enzyme (ACE) gene insertion/ deletion (I/D) polymorphism and pathological processes such as coronary artery disease (CAD) has been investigated previously with discordant results.
This study was designed to determine the association between ACE gene I/D polymorphism and CAD in an Iranian population.
Methods: A total of 1050 individuals who were referred to Tehran Heart Center for coronary angiography were recruited. Six hundred seventy-six CAD-positive patients (documented by coronary angiography and Gensini scores higher than 6) and
374 CAD-negative patients were evaluated for ACE gene I/D polymorphism via the Polymerase Chain Reaction Amplification method. The patients’ age, sex, smoking status and its duration as well as familial history of CAD, hypertension, and diabetes mellitus were recorded.
Results: Five hundred four (74.6%) of the CAD-positive patients were male, and the mean age of this group was 60 (60 ±10). In the CAD-negative individuals, the mean age was 56 (56 ± 10) and 196 of them were male (52.4%). After the analysis of all the groups and gender subgroups, neither genotype nor allele frequency was significantly different between the CAD- positive and CAD-negative groups (p values for genotypes and allele frequencies were 0.494 and 0.397, respectively).
Conclusion: ACE gene I/D polymorphism was not associated with an increased risk of CAD in an Iranian population. |
topic |
Coronary artery disease • Polymorphism genetic • Iran |
url |
https://jthc.tums.ac.ir/index.php/jthc/article/view/288 |
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