Impact of Coagulation Profile on Outcome of Head Injury
Introduction: Worldwide, head injury is recognized as a major public health problem. Head injury patients often develop consumptive coagulopathy in the absence of other trauma or haemorrhages. The release of tissue factor from the damaged brain is postulated as the cause of coagulopathy. Aim: T...
Main Authors: | , , , , |
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Format: | Article |
Language: | English |
Published: |
JCDR Research and Publications Private Limited
2016-01-01
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Series: | Journal of Clinical and Diagnostic Research |
Subjects: | |
Online Access: | https://jcdr.net/articles/PDF/7029/14638_CE(Ra1)_F(GH)_PF1(BMAK)_PFA(AK)_PF2(PAG).pdf |
Summary: | Introduction: Worldwide, head injury is recognized as a major
public health problem. Head injury patients often develop
consumptive coagulopathy in the absence of other trauma or
haemorrhages. The release of tissue factor from the damaged
brain is postulated as the cause of coagulopathy.
Aim: To know the impact of coagulation profile derangements
and their effect on the outcome of head injury patients.
Materials and Methods: Fifty patients in the age group of 20-
70 years admitted with isolated head injury were taken. Samples
of complete haemogram (CBC), prothrombin time (PTI), partial
thromboplastin time (PTK), D-Dimers and fibrinogen were
taken within 24 hour of admission. Coagulopathy was defined
as platelet counts < 100,000 cells/mm2
and PTI >15 seconds
or a DIC score more than 4. The outcome in each group was
measured according to Glasgow outcome score. Coagulation
abnormalities were analysed.
Results: In case of severe head injury, p-values in patients
who died with regard to DIC score, Prothrombin time and APTT
were found to be significant (p< 0.05). For D-Dimers, fibrinogen
and platelets counts the p-value was not significant. In case of
moderate head injury, p-values in patients who died with regard
to DIC score, platelet count, Prothrombin time, D-Dimer and
APTT were found to be significant (0.05). For fibrinogen level
it was insignificant. The mean DIC score and mean GOS in the
severe head injury patients was significant (p<0.001).
Conclusion: Patients with isolated head injury are at risk of
development of coagulation abnormalities, which is associated
with poor outcome. Based on our results we also emphasize
the importance of early diagnosis of coagulation abnormalities
in isolated head injury patients. |
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ISSN: | 2249-782X 0973-709X |