PKA inhibits WNT signalling in adrenal cortex zonation and prevents malignant tumour development

PKA inhibits WNT signalling in adrenal cortex zonation and prevents malignant tumour development

The adrenal cortex undergoes functional zonation to generate an outer zona glomerulosa (ZG) and inner zona fasciculata (ZF), but how this is regulated at a molecular level is unclear. Here, the authors show that ZG differentiation is stimulated by WNT signalling and that PKA blocks WNT signalling to...

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Main Authors: Coralie Drelon, Annabel Berthon, Isabelle Sahut-Barnola, Mickaël Mathieu, Typhanie Dumontet, Stéphanie Rodriguez, Marie Batisse-Lignier, Houda Tabbal, Igor Tauveron, Anne-Marie Lefrançois-Martinez, Jean-Christophe Pointud, Celso E. Gomez-Sanchez, Seppo Vainio, Jingdong Shan, Sonia Sacco, Andreas Schedl, Constantine A. Stratakis, Antoine Martinez, Pierre Val
Format: Article
Language:English
Published: Nature Publishing Group 2016-09-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms12751
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spelling doaj-47e9d947aff442c7b85b4848141ee1ea2021-05-11T11:22:56ZengNature Publishing GroupNature Communications2041-17232016-09-017111410.1038/ncomms12751PKA inhibits WNT signalling in adrenal cortex zonation and prevents malignant tumour developmentCoralie Drelon0Annabel Berthon1Isabelle Sahut-Barnola2Mickaël Mathieu3Typhanie Dumontet4Stéphanie Rodriguez5Marie Batisse-Lignier6Houda Tabbal7Igor Tauveron8Anne-Marie Lefrançois-Martinez9Jean-Christophe Pointud10Celso E. Gomez-Sanchez11Seppo Vainio12Jingdong Shan13Sonia Sacco14Andreas Schedl15Constantine A. Stratakis16Antoine Martinez17Pierre Val18CNRS, UMR 6293, GReD, Inserm U1103, Clermont UniversitéCNRS, UMR 6293, GReD, Inserm U1103, Clermont UniversitéCNRS, UMR 6293, GReD, Inserm U1103, Clermont UniversitéCNRS, UMR 6293, GReD, Inserm U1103, Clermont UniversitéCNRS, UMR 6293, GReD, Inserm U1103, Clermont UniversitéCNRS, UMR 6293, GReD, Inserm U1103, Clermont UniversitéCNRS, UMR 6293, GReD, Inserm U1103, Clermont UniversitéCNRS, UMR 6293, GReD, Inserm U1103, Clermont UniversitéCNRS, UMR 6293, GReD, Inserm U1103, Clermont UniversitéCNRS, UMR 6293, GReD, Inserm U1103, Clermont UniversitéCNRS, UMR 6293, GReD, Inserm U1103, Clermont UniversitéDivision of Endocrinology, G.V. (Sonny) Montgomery VA Medical CenterBiocenter Oulu, Laboratory of Developmental Biology, InfoTech Oulu, Center for cell Matrix Research, Faculty of Biochemistry and Molecular Medicine, University of OuluBiocenter Oulu, Laboratory of Developmental Biology, InfoTech Oulu, Center for cell Matrix Research, Faculty of Biochemistry and Molecular Medicine, University of OuluInserm UMR1091, CNRS UMR 7277, Institute of Biology ValroseInserm UMR1091, CNRS UMR 7277, Institute of Biology ValroseDevelopmental Endocrine Oncology and Genetics, Section on Genetics and Endocrinology, Eunice Kennedy Shriver National Institute of Child Health and Human DevelopmentCNRS, UMR 6293, GReD, Inserm U1103, Clermont UniversitéCNRS, UMR 6293, GReD, Inserm U1103, Clermont UniversitéThe adrenal cortex undergoes functional zonation to generate an outer zona glomerulosa (ZG) and inner zona fasciculata (ZF), but how this is regulated at a molecular level is unclear. Here, the authors show that ZG differentiation is stimulated by WNT signalling and that PKA blocks WNT signalling to allow ZF differentiation and also prevents WNT-induced cancer development.https://doi.org/10.1038/ncomms12751
collection DOAJ
language English
format Article
sources DOAJ
author Coralie Drelon
Annabel Berthon
Isabelle Sahut-Barnola
Mickaël Mathieu
Typhanie Dumontet
Stéphanie Rodriguez
Marie Batisse-Lignier
Houda Tabbal
Igor Tauveron
Anne-Marie Lefrançois-Martinez
Jean-Christophe Pointud
Celso E. Gomez-Sanchez
Seppo Vainio
Jingdong Shan
Sonia Sacco
Andreas Schedl
Constantine A. Stratakis
Antoine Martinez
Pierre Val
spellingShingle Coralie Drelon
Annabel Berthon
Isabelle Sahut-Barnola
Mickaël Mathieu
Typhanie Dumontet
Stéphanie Rodriguez
Marie Batisse-Lignier
Houda Tabbal
Igor Tauveron
Anne-Marie Lefrançois-Martinez
Jean-Christophe Pointud
Celso E. Gomez-Sanchez
Seppo Vainio
Jingdong Shan
Sonia Sacco
Andreas Schedl
Constantine A. Stratakis
Antoine Martinez
Pierre Val
PKA inhibits WNT signalling in adrenal cortex zonation and prevents malignant tumour development
Nature Communications
author_facet Coralie Drelon
Annabel Berthon
Isabelle Sahut-Barnola
Mickaël Mathieu
Typhanie Dumontet
Stéphanie Rodriguez
Marie Batisse-Lignier
Houda Tabbal
Igor Tauveron
Anne-Marie Lefrançois-Martinez
Jean-Christophe Pointud
Celso E. Gomez-Sanchez
Seppo Vainio
Jingdong Shan
Sonia Sacco
Andreas Schedl
Constantine A. Stratakis
Antoine Martinez
Pierre Val
author_sort Coralie Drelon
title PKA inhibits WNT signalling in adrenal cortex zonation and prevents malignant tumour development
title_short PKA inhibits WNT signalling in adrenal cortex zonation and prevents malignant tumour development
title_full PKA inhibits WNT signalling in adrenal cortex zonation and prevents malignant tumour development
title_fullStr PKA inhibits WNT signalling in adrenal cortex zonation and prevents malignant tumour development
title_full_unstemmed PKA inhibits WNT signalling in adrenal cortex zonation and prevents malignant tumour development
title_sort pka inhibits wnt signalling in adrenal cortex zonation and prevents malignant tumour development
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2016-09-01
description The adrenal cortex undergoes functional zonation to generate an outer zona glomerulosa (ZG) and inner zona fasciculata (ZF), but how this is regulated at a molecular level is unclear. Here, the authors show that ZG differentiation is stimulated by WNT signalling and that PKA blocks WNT signalling to allow ZF differentiation and also prevents WNT-induced cancer development.
url https://doi.org/10.1038/ncomms12751
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