Dietary Supplements on Controlling Multiple Sclerosis Symptoms and Relapses: Current Clinical Evidence and Future Perspectives
<b>Background:</b> Multiple sclerosis (MS) constitutes a chronic progressive demyelinating disease which negatively affects the central nervous system. MS symptoms detrimentally affect the quality of life, as well as the life expectancy of MS patients. In this aspect, the present study a...
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doaj-47f212a4bbdc4b4b8a0f52e2129095d22020-11-25T01:21:51ZengMDPI AGMedicines2305-63202019-09-01639510.3390/medicines6030095medicines6030095Dietary Supplements on Controlling Multiple Sclerosis Symptoms and Relapses: Current Clinical Evidence and Future PerspectivesChristina Tryfonos0Maria Mantzorou1Dimitris Fotiou2Michael Vrizas3Konstantinos Vadikolias4Eleni Pavlidou5Constantinos Giaginis6Department of Food Science and Nutrition, University of the Aegean, Myrina, 81400 Lemnos, GreeceDepartment of Food Science and Nutrition, University of the Aegean, Myrina, 81400 Lemnos, GreeceDepartment of Neurology, School of Medicine, Aristotelian University of Thessaloniki, 54624 Thessaloniki, GreeceDepartment of Neurology, School of Medicine, Democritus University of Thrace, 68100 Alexandroupoli, GreeceDepartment of Neurology, School of Medicine, Democritus University of Thrace, 68100 Alexandroupoli, GreeceDepartment of Food Science and Nutrition, University of the Aegean, Myrina, 81400 Lemnos, GreeceDepartment of Food Science and Nutrition, University of the Aegean, Myrina, 81400 Lemnos, Greece<b>Background:</b> Multiple sclerosis (MS) constitutes a chronic progressive demyelinating disease which negatively affects the central nervous system. MS symptoms detrimentally affect the quality of life, as well as the life expectancy of MS patients. In this aspect, the present study aims to critically summarize and evaluate the currently available clinical studies focusing on the potential beneficial effects of dietary supplements on controlling MS symptomatology and relapse. <b>Methods:</b> PubMed database was comprehensively searched, using relative keywords to identify clinical trials that investigated the beneficial effects of dietary supplementation against MS symptomatology and progression. 40 clinical trials were found, which were divided into categories. <b>Results:</b> Nutritional status of MS patients, as well as supplementation have been suggested as potential factors affecting progression. Several substantial studies have documented a systematically high prevalence of vitamin A, B12 and D3 deficiency amongst MS patients. At present, clinical data have suggested that most of the dietary supplements under study may exert antioxidant and anti-inflammatory properties, improving depression symptomatology and quality of life overall. However, malnutrition risk in MS patients has not been adequately explored in order for more precise conclusions to be drawn. The supplements that may have a positive effect on MS are vitamins, fatty acids, antioxidants, phytochemicals and melatonin. <b>Conclusions:</b> Several dietary supplements may decrease inflammation and fatigue, also increasing also autoimmunity tolerance in MS patients, and thus improving quality of life and life expectancy. Currently, there is no effective clinical indication for applying dietary supplementation as complementary treatment against MS symptomatology.https://www.mdpi.com/2305-6320/6/3/95dietary supplementsmultiple sclerosisinflammationantioxidantclinical studies |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Christina Tryfonos Maria Mantzorou Dimitris Fotiou Michael Vrizas Konstantinos Vadikolias Eleni Pavlidou Constantinos Giaginis |
spellingShingle |
Christina Tryfonos Maria Mantzorou Dimitris Fotiou Michael Vrizas Konstantinos Vadikolias Eleni Pavlidou Constantinos Giaginis Dietary Supplements on Controlling Multiple Sclerosis Symptoms and Relapses: Current Clinical Evidence and Future Perspectives Medicines dietary supplements multiple sclerosis inflammation antioxidant clinical studies |
author_facet |
Christina Tryfonos Maria Mantzorou Dimitris Fotiou Michael Vrizas Konstantinos Vadikolias Eleni Pavlidou Constantinos Giaginis |
author_sort |
Christina Tryfonos |
title |
Dietary Supplements on Controlling Multiple Sclerosis Symptoms and Relapses: Current Clinical Evidence and Future Perspectives |
title_short |
Dietary Supplements on Controlling Multiple Sclerosis Symptoms and Relapses: Current Clinical Evidence and Future Perspectives |
title_full |
Dietary Supplements on Controlling Multiple Sclerosis Symptoms and Relapses: Current Clinical Evidence and Future Perspectives |
title_fullStr |
Dietary Supplements on Controlling Multiple Sclerosis Symptoms and Relapses: Current Clinical Evidence and Future Perspectives |
title_full_unstemmed |
Dietary Supplements on Controlling Multiple Sclerosis Symptoms and Relapses: Current Clinical Evidence and Future Perspectives |
title_sort |
dietary supplements on controlling multiple sclerosis symptoms and relapses: current clinical evidence and future perspectives |
publisher |
MDPI AG |
series |
Medicines |
issn |
2305-6320 |
publishDate |
2019-09-01 |
description |
<b>Background:</b> Multiple sclerosis (MS) constitutes a chronic progressive demyelinating disease which negatively affects the central nervous system. MS symptoms detrimentally affect the quality of life, as well as the life expectancy of MS patients. In this aspect, the present study aims to critically summarize and evaluate the currently available clinical studies focusing on the potential beneficial effects of dietary supplements on controlling MS symptomatology and relapse. <b>Methods:</b> PubMed database was comprehensively searched, using relative keywords to identify clinical trials that investigated the beneficial effects of dietary supplementation against MS symptomatology and progression. 40 clinical trials were found, which were divided into categories. <b>Results:</b> Nutritional status of MS patients, as well as supplementation have been suggested as potential factors affecting progression. Several substantial studies have documented a systematically high prevalence of vitamin A, B12 and D3 deficiency amongst MS patients. At present, clinical data have suggested that most of the dietary supplements under study may exert antioxidant and anti-inflammatory properties, improving depression symptomatology and quality of life overall. However, malnutrition risk in MS patients has not been adequately explored in order for more precise conclusions to be drawn. The supplements that may have a positive effect on MS are vitamins, fatty acids, antioxidants, phytochemicals and melatonin. <b>Conclusions:</b> Several dietary supplements may decrease inflammation and fatigue, also increasing also autoimmunity tolerance in MS patients, and thus improving quality of life and life expectancy. Currently, there is no effective clinical indication for applying dietary supplementation as complementary treatment against MS symptomatology. |
topic |
dietary supplements multiple sclerosis inflammation antioxidant clinical studies |
url |
https://www.mdpi.com/2305-6320/6/3/95 |
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