Innate immunity limits protective adaptive immune responses against pre-erythrocytic malaria parasites

Innate immunity limits protective adaptive immune responses against pre-erythrocytic malaria parasites

Here, Minkah et al. show that, while immunization with replication-competent Plasmodium parasites can confer sterile protection against infection, it also induces a type I interferon response that adversely affects anti-malaria immunity by affecting numbers of protective hepatic CD8 T cells and CD8...

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Main Authors: Nana K. Minkah, Brandon K. Wilder, Amina A. Sheikh, Thomas Martinson, Lisa Wegmair, Ashley M. Vaughan, Stefan H. I. Kappe
Format: Article
Language:English
Published: Nature Publishing Group 2019-09-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-11819-0
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spelling doaj-4803ab594660449eb646c58a1da8b3d42021-05-11T12:01:50ZengNature Publishing GroupNature Communications2041-17232019-09-0110111410.1038/s41467-019-11819-0Innate immunity limits protective adaptive immune responses against pre-erythrocytic malaria parasitesNana K. Minkah0Brandon K. Wilder1Amina A. Sheikh2Thomas Martinson3Lisa Wegmair4Ashley M. Vaughan5Stefan H. I. Kappe6Center for Global Infectious Disease Research, Seattle Children’s Research InstituteCenter for Global Infectious Disease Research, Seattle Children’s Research InstituteCenter for Global Infectious Disease Research, Seattle Children’s Research InstituteCenter for Global Infectious Disease Research, Seattle Children’s Research InstituteCenter for Global Infectious Disease Research, Seattle Children’s Research InstituteCenter for Global Infectious Disease Research, Seattle Children’s Research InstituteCenter for Global Infectious Disease Research, Seattle Children’s Research InstituteHere, Minkah et al. show that, while immunization with replication-competent Plasmodium parasites can confer sterile protection against infection, it also induces a type I interferon response that adversely affects anti-malaria immunity by affecting numbers of protective hepatic CD8 T cells and CD8 T cell function.https://doi.org/10.1038/s41467-019-11819-0
collection DOAJ
language English
format Article
sources DOAJ
author Nana K. Minkah
Brandon K. Wilder
Amina A. Sheikh
Thomas Martinson
Lisa Wegmair
Ashley M. Vaughan
Stefan H. I. Kappe
spellingShingle Nana K. Minkah
Brandon K. Wilder
Amina A. Sheikh
Thomas Martinson
Lisa Wegmair
Ashley M. Vaughan
Stefan H. I. Kappe
Innate immunity limits protective adaptive immune responses against pre-erythrocytic malaria parasites
Nature Communications
author_facet Nana K. Minkah
Brandon K. Wilder
Amina A. Sheikh
Thomas Martinson
Lisa Wegmair
Ashley M. Vaughan
Stefan H. I. Kappe
author_sort Nana K. Minkah
title Innate immunity limits protective adaptive immune responses against pre-erythrocytic malaria parasites
title_short Innate immunity limits protective adaptive immune responses against pre-erythrocytic malaria parasites
title_full Innate immunity limits protective adaptive immune responses against pre-erythrocytic malaria parasites
title_fullStr Innate immunity limits protective adaptive immune responses against pre-erythrocytic malaria parasites
title_full_unstemmed Innate immunity limits protective adaptive immune responses against pre-erythrocytic malaria parasites
title_sort innate immunity limits protective adaptive immune responses against pre-erythrocytic malaria parasites
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2019-09-01
description Here, Minkah et al. show that, while immunization with replication-competent Plasmodium parasites can confer sterile protection against infection, it also induces a type I interferon response that adversely affects anti-malaria immunity by affecting numbers of protective hepatic CD8 T cells and CD8 T cell function.
url https://doi.org/10.1038/s41467-019-11819-0
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