99mTc-MIBI Scintigraphy to differentiate malignancies from benign lesions detected on Planar bone scans
The aim of study was to evaluate the effectiveness of 99mTc-MIBI (hexakis 2-methoxyisobutyl isonitrile) scintigraphy to differentiate malignant from benign lesions, detected on 99mTc-MDP planar bone scans. 59 patients with bony lesions were studied prospectively and compared with histopathology. Eac...
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doaj-4818886d1a6a401bbc31e6d5b8ba56a42020-11-25T01:54:57ZengSpringerOpenThe Egyptian Journal of Radiology and Nuclear Medicine0378-603X2016-03-0147126727310.1016/j.ejrnm.2015.09.01199mTc-MIBI Scintigraphy to differentiate malignancies from benign lesions detected on Planar bone scansAniqa JabeenHassan RazaBashir AhmedS. Minhaj MaqboolSumaira MushtaqLubna Khan JadoonMussaratulainMohammd Ali MemonThe aim of study was to evaluate the effectiveness of 99mTc-MIBI (hexakis 2-methoxyisobutyl isonitrile) scintigraphy to differentiate malignant from benign lesions, detected on 99mTc-MDP planar bone scans. 59 patients with bony lesions were studied prospectively and compared with histopathology. Each patient underwent a 99mTc-MDP scan, and if evidence of lesion found, patient underwent 99mTc-MIBI scintigraphy after three to four days. 99mTc-MIBI scans were evaluated visually and quantitatively. For quantitative analysis count ratio of lesion to contralateral normal side (L/C) was taken and Student T test was applied. 99mTc-MDP scans showed increase tracer uptake but no significant difference between benign and malignant uptake was seen. Significant difference (p value 0.015), was seen in malignant (L/C 3.51 ± 1.02) and benign lesions (L/C 2.50 ± 0.42) on 99mTc-MIBI scan. Three of thirty benign lesions did not show significant 99mTc-MIBI uptake. Six malignant lesions appeared as false negatives. Specificity of 99mTc-MIBI was 86.66%, Negative Predictive Value (NPV) 81.25% whereas the sensitivity was 79.31%. 99mTc-MIBI scintigraphy provides its usefulness by distinguishing malignant from benign lesions along with correct identification of metastatic lesions. NPV points toward its ability to correctly diagnose the normal (benign) cases. However biopsy still remains the gold standard and a definitive diagnostic modality.http://www.sciencedirect.com/science/article/pii/S0378603X1500210799mTc-MIBI scintigraphyMusculoskeletal tumorsMalignancyTumor imaging radiopharmaceuticals |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Aniqa Jabeen Hassan Raza Bashir Ahmed S. Minhaj Maqbool Sumaira Mushtaq Lubna Khan Jadoon Mussaratulain Mohammd Ali Memon |
spellingShingle |
Aniqa Jabeen Hassan Raza Bashir Ahmed S. Minhaj Maqbool Sumaira Mushtaq Lubna Khan Jadoon Mussaratulain Mohammd Ali Memon 99mTc-MIBI Scintigraphy to differentiate malignancies from benign lesions detected on Planar bone scans The Egyptian Journal of Radiology and Nuclear Medicine 99mTc-MIBI scintigraphy Musculoskeletal tumors Malignancy Tumor imaging radiopharmaceuticals |
author_facet |
Aniqa Jabeen Hassan Raza Bashir Ahmed S. Minhaj Maqbool Sumaira Mushtaq Lubna Khan Jadoon Mussaratulain Mohammd Ali Memon |
author_sort |
Aniqa Jabeen |
title |
99mTc-MIBI Scintigraphy to differentiate malignancies from benign lesions detected on Planar bone scans |
title_short |
99mTc-MIBI Scintigraphy to differentiate malignancies from benign lesions detected on Planar bone scans |
title_full |
99mTc-MIBI Scintigraphy to differentiate malignancies from benign lesions detected on Planar bone scans |
title_fullStr |
99mTc-MIBI Scintigraphy to differentiate malignancies from benign lesions detected on Planar bone scans |
title_full_unstemmed |
99mTc-MIBI Scintigraphy to differentiate malignancies from benign lesions detected on Planar bone scans |
title_sort |
99mtc-mibi scintigraphy to differentiate malignancies from benign lesions detected on planar bone scans |
publisher |
SpringerOpen |
series |
The Egyptian Journal of Radiology and Nuclear Medicine |
issn |
0378-603X |
publishDate |
2016-03-01 |
description |
The aim of study was to evaluate the effectiveness of 99mTc-MIBI (hexakis 2-methoxyisobutyl isonitrile) scintigraphy to differentiate malignant from benign lesions, detected on 99mTc-MDP planar bone scans. 59 patients with bony lesions were studied prospectively and compared with histopathology. Each patient underwent a 99mTc-MDP scan, and if evidence of lesion found, patient underwent 99mTc-MIBI scintigraphy after three to four days. 99mTc-MIBI scans were evaluated visually and quantitatively. For quantitative analysis count ratio of lesion to contralateral normal side (L/C) was taken and Student T test was applied.
99mTc-MDP scans showed increase tracer uptake but no significant difference between benign and malignant uptake was seen. Significant difference (p value 0.015), was seen in malignant (L/C 3.51 ± 1.02) and benign lesions (L/C 2.50 ± 0.42) on 99mTc-MIBI scan. Three of thirty benign lesions did not show significant 99mTc-MIBI uptake. Six malignant lesions appeared as false negatives. Specificity of 99mTc-MIBI was 86.66%, Negative Predictive Value (NPV) 81.25% whereas the sensitivity was 79.31%.
99mTc-MIBI scintigraphy provides its usefulness by distinguishing malignant from benign lesions along with correct identification of metastatic lesions. NPV points toward its ability to correctly diagnose the normal (benign) cases. However biopsy still remains the gold standard and a definitive diagnostic modality. |
topic |
99mTc-MIBI scintigraphy Musculoskeletal tumors Malignancy Tumor imaging radiopharmaceuticals |
url |
http://www.sciencedirect.com/science/article/pii/S0378603X15002107 |
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