Juvenile Granulosa Cell Tumour of Ovary in Young Females- A Clinico-pathological Evaluation of 11 Patients
Introduction: Ovarian sex cord-stromal tumours, including Granulosa Cell Tumours (GCTs), are a group of neoplasm that occurs rarely, especially in children. Only 0.1% of all ovarian tumours and 4-5% of GCTs occur in children. They commonly present as precocious puberty especially in prepubertal...
Main Authors: | , , |
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Format: | Article |
Language: | English |
Published: |
JCDR Research and Publications Private Limited
2020-08-01
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Series: | Journal of Clinical and Diagnostic Research |
Subjects: | |
Online Access: | https://jcdr.net/articles/PDF/13955/45128_CE[Ra1]_F(KM)_PF1(AG_SHU)_PN(SL).pdf |
Summary: | Introduction: Ovarian sex cord-stromal tumours, including
Granulosa Cell Tumours (GCTs), are a group of neoplasm that
occurs rarely, especially in children. Only 0.1% of all ovarian
tumours and 4-5% of GCTs occur in children. They commonly
present as precocious puberty especially in prepubertal girls.
Aim: To analyse the clinico-pathological features along with the
laboratory findings of ovarian mass.
Materials and Methods: A prospective study in tertiary
care teaching institutions was carried out during a three year
study period starting from April 2017 to March 2020. The
study was carried out in tertiary care teaching institutions i.e.,
VCSGG Medical Sciences and Research Institute, Srinagar
Garhwal, PauriGarhwal, Doon Medical College, Dehradun
and Rohilkhand Medical College, Bareilly. A total of 11 cases
of Juvenile Granulosa Cell Tumour (JGCT) among girls in
the age group of 5-13 years who presented with precocious
puberty were included in the present study. The results were
analysed especially the clinico-laboratory parameters including
histopathology and Immunohistochemistry (IHC) findings. All
the patients underwent resection of the ovarian mass and were
subjected to histopathological examination. Microscopy and
IHC was compatible with the diagnosis of juvenile GCT in all
the 11 cases.
Results: Majority of the patients with GCTs of the ovary
presented in the early stage. Of the 11 cases included, only
one patient was aged 13 years; seven were in the age group
of 5-8 years and three in the 9-12 years of age group. The
laboratory profile in all showed an elevated Estradiol level, low
Luteinizing Hormone (LH) and Follicle Stimulating Hormone
(FSH) levels. Among the thyroid profile only the Triiodothyronine
(T3) levels were raised while Thyroid Stimulating Hormone
(TSH) and Thyroxine (T4) levels were within normal limits. All
cases were histopathologically proved and confirmed using IHC
markers. Surgery is the primary treatment modality for GCTs.
Conclusion: Histopathology along with specific IHC is
important in the diagnosis of JGCT. A careful search provides
good insight of the tumour and its final outcome. Diagnosing
JGCT especially in the early stage is important as they carry a
favourable prognosis when treated in the initial phase. |
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ISSN: | 2249-782X 0973-709X |