Association Between Renal Dysfunction and Low HDL Cholesterol Among the Elderly in China
Objective: Chronic kidney disease (CKD) and cardiovascular disease (CVD) have a high morbidity and mortality among the elderly. Low levels of high-density lipoprotein cholesterol (HDL-C), a traditional risk marker for CVD, are common in CKD patients. Little is known about the association of low HDL-...
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Frontiers Media S.A.
2021-05-01
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Series: | Frontiers in Cardiovascular Medicine |
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Online Access: | https://www.frontiersin.org/articles/10.3389/fcvm.2021.644208/full |
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doaj-48248ba42117474f8f9600c89900d943 |
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record_format |
Article |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Aijun You Aijun You Aijun You Yaxin Li Yaxin Li Yaxin Li Brian Tomlinson Brian Tomlinson Brian Tomlinson Longfei Yue Kaijie Zhao Huimin Fan Huimin Fan Zhongmin Liu Zhongmin Liu Yuzhen Zhang Yuzhen Zhang Liang Zheng Liang Zheng |
spellingShingle |
Aijun You Aijun You Aijun You Yaxin Li Yaxin Li Yaxin Li Brian Tomlinson Brian Tomlinson Brian Tomlinson Longfei Yue Kaijie Zhao Huimin Fan Huimin Fan Zhongmin Liu Zhongmin Liu Yuzhen Zhang Yuzhen Zhang Liang Zheng Liang Zheng Association Between Renal Dysfunction and Low HDL Cholesterol Among the Elderly in China Frontiers in Cardiovascular Medicine renal dysfunction dyslipidemia estimated glomerular filtration rate high-density lipoprotein cholesterol cardiovascular prevention |
author_facet |
Aijun You Aijun You Aijun You Yaxin Li Yaxin Li Yaxin Li Brian Tomlinson Brian Tomlinson Brian Tomlinson Longfei Yue Kaijie Zhao Huimin Fan Huimin Fan Zhongmin Liu Zhongmin Liu Yuzhen Zhang Yuzhen Zhang Liang Zheng Liang Zheng |
author_sort |
Aijun You |
title |
Association Between Renal Dysfunction and Low HDL Cholesterol Among the Elderly in China |
title_short |
Association Between Renal Dysfunction and Low HDL Cholesterol Among the Elderly in China |
title_full |
Association Between Renal Dysfunction and Low HDL Cholesterol Among the Elderly in China |
title_fullStr |
Association Between Renal Dysfunction and Low HDL Cholesterol Among the Elderly in China |
title_full_unstemmed |
Association Between Renal Dysfunction and Low HDL Cholesterol Among the Elderly in China |
title_sort |
association between renal dysfunction and low hdl cholesterol among the elderly in china |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Cardiovascular Medicine |
issn |
2297-055X |
publishDate |
2021-05-01 |
description |
Objective: Chronic kidney disease (CKD) and cardiovascular disease (CVD) have a high morbidity and mortality among the elderly. Low levels of high-density lipoprotein cholesterol (HDL-C), a traditional risk marker for CVD, are common in CKD patients. Little is known about the association of low HDL-C with renal dysfunction in the community dwelling population.Methods: This was a population-based cross-sectional study included 4,753 participants enrolled in a prospective study, the Shanghai Elderly Cardiovascular Health (SHECH) study. Estimated glomerular filtration rate (eGFR), calculated by the Chinese Modification of Diet in Renal Disease (C-MDRD equation), was used to assess renal dysfunction. Associations between renal dysfunction and low HDL-C were evaluated using multiple logistic regression models and restricted cubic splines.Results: Of 4,649 individuals who met inclusion criteria, 620 (13.34%) had low HDL-C at <40 mg/dl. In the fully adjusted model, lower eGFR of <60 ml/min/1.73 m2 (OR, 2.03; 95% CI, 1.21–3.43) and marginal eGFR of 60 to 90 ml/min/1.73 m2 (OR, 1.26; 95% CI, 1.01–1.58) were significantly associated with low HDL-C, compared with normal eGFR of ≥90 ml/min/1.73 m2. Moreover, consistent findings were obtained in subsidiary analyses using the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation. Fully adjusted cubic spline models indicated a significant dose-response relationship between eGFR and low HDL-C (P for non-linearity, 0.356).Conclusion: In this general elderly population, renal dysfunction was independently and significantly associated with low HDL-C, and the prevalence of low HDL-C increased with decreasing eGFR, such that even slight changes in renal function may be associated with altered lipid levels. |
topic |
renal dysfunction dyslipidemia estimated glomerular filtration rate high-density lipoprotein cholesterol cardiovascular prevention |
url |
https://www.frontiersin.org/articles/10.3389/fcvm.2021.644208/full |
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doaj-48248ba42117474f8f9600c89900d9432021-05-12T06:21:00ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2021-05-01810.3389/fcvm.2021.644208644208Association Between Renal Dysfunction and Low HDL Cholesterol Among the Elderly in ChinaAijun You0Aijun You1Aijun You2Yaxin Li3Yaxin Li4Yaxin Li5Brian Tomlinson6Brian Tomlinson7Brian Tomlinson8Longfei Yue9Kaijie Zhao10Huimin Fan11Huimin Fan12Zhongmin Liu13Zhongmin Liu14Yuzhen Zhang15Yuzhen Zhang16Liang Zheng17Liang Zheng18Shanghai Heart Failure Research Center, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, ChinaResearch Center for Translational Medicine, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, ChinaDepartment of Epidemiology and Public Health, Tongji University School of Medicine, Shanghai, ChinaShanghai Heart Failure Research Center, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, ChinaResearch Center for Translational Medicine, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, ChinaDepartment of Epidemiology and Public Health, Tongji University School of Medicine, Shanghai, ChinaShanghai Heart Failure Research Center, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, ChinaResearch Center for Translational Medicine, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, ChinaFaculty of Medicine, Macau University of Science and Technology, Macau, ChinaAnshun People's Hospital, Guizhou, ChinaCommunity Health Service Center, Shanghai, ChinaShanghai Heart Failure Research Center, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, ChinaResearch Center for Translational Medicine, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, ChinaShanghai Heart Failure Research Center, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, ChinaResearch Center for Translational Medicine, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, ChinaShanghai Heart Failure Research Center, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, ChinaResearch Center for Translational Medicine, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, ChinaShanghai Heart Failure Research Center, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, ChinaResearch Center for Translational Medicine, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, ChinaObjective: Chronic kidney disease (CKD) and cardiovascular disease (CVD) have a high morbidity and mortality among the elderly. Low levels of high-density lipoprotein cholesterol (HDL-C), a traditional risk marker for CVD, are common in CKD patients. Little is known about the association of low HDL-C with renal dysfunction in the community dwelling population.Methods: This was a population-based cross-sectional study included 4,753 participants enrolled in a prospective study, the Shanghai Elderly Cardiovascular Health (SHECH) study. Estimated glomerular filtration rate (eGFR), calculated by the Chinese Modification of Diet in Renal Disease (C-MDRD equation), was used to assess renal dysfunction. Associations between renal dysfunction and low HDL-C were evaluated using multiple logistic regression models and restricted cubic splines.Results: Of 4,649 individuals who met inclusion criteria, 620 (13.34%) had low HDL-C at <40 mg/dl. In the fully adjusted model, lower eGFR of <60 ml/min/1.73 m2 (OR, 2.03; 95% CI, 1.21–3.43) and marginal eGFR of 60 to 90 ml/min/1.73 m2 (OR, 1.26; 95% CI, 1.01–1.58) were significantly associated with low HDL-C, compared with normal eGFR of ≥90 ml/min/1.73 m2. Moreover, consistent findings were obtained in subsidiary analyses using the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation. Fully adjusted cubic spline models indicated a significant dose-response relationship between eGFR and low HDL-C (P for non-linearity, 0.356).Conclusion: In this general elderly population, renal dysfunction was independently and significantly associated with low HDL-C, and the prevalence of low HDL-C increased with decreasing eGFR, such that even slight changes in renal function may be associated with altered lipid levels.https://www.frontiersin.org/articles/10.3389/fcvm.2021.644208/fullrenal dysfunctiondyslipidemiaestimated glomerular filtration ratehigh-density lipoprotein cholesterolcardiovascular prevention |