Inhibition of Glycogen Synthase Kinase 3β Increases the Proportion and Suppressive Function of CD19+CD24hiCD27+ Breg Cells

Inhibition of Glycogen Synthase Kinase 3β Increases the Proportion and Suppressive Function of CD19+CD24hiCD27+ Breg Cells

CD19+CD24hiCD27+ memory Breg cells exhibit decreased abundance in patients with chronic graft-versus-host disease (cGVHD) after liver transplantation and produce less IL-10 than those from patients without cGVHD and healthy donors. Due to the lack of Breg cells and the difficulty in expanding them i...

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Bibliographic Details
Main Authors: Jinyang Li, Ji Gao, Haoming Zhou, Jinren Zhou, Zhenghua Deng, Yunjie Lu, Jianhua Rao, Guwei Ji, Jian Gu, Xinxiang Yang, Yongxiang Xia, Xuehao Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-12-01
Series:Frontiers in Immunology
Subjects:
liver transplantation
graft-versus-host disease
mBreg cells
GSK-3β
NFATc1
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2020.603288/full

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