Precision Phenomapping of Acute Coronary Syndromes to Improve Patient Outcomes
Acute coronary syndromes (ACS) are a global leading cause of death. These syndromes show heterogeneity in presentation, mechanisms, outcomes and responses to treatment. Precision medicine aims to identify and synthesize unique features in individuals, translating the acquired data into improved pers...
Main Authors: | , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2021-04-01
|
Series: | Journal of Clinical Medicine |
Subjects: | |
Online Access: | https://www.mdpi.com/2077-0383/10/8/1755 |
id |
doaj-4838a4c587424f039c15d0a41f9d526a |
---|---|
record_format |
Article |
spelling |
doaj-4838a4c587424f039c15d0a41f9d526a2021-04-18T23:00:04ZengMDPI AGJournal of Clinical Medicine2077-03832021-04-01101755175510.3390/jcm10081755Precision Phenomapping of Acute Coronary Syndromes to Improve Patient OutcomesFelicita Andreotti0Adelaide Iervolino1Eliano Pio Navarese2Aldo Pietro Maggioni3Filippo Crea4Giovanni Scambia5Catholic University of the Sacred Heart, 00168 Rome, ItalyCatholic University of the Sacred Heart, 00168 Rome, ItalyInterventional Cardiology and Cardiovascular Medicine Research, Department of Cardiology and Internal Medicine, Nicolaus Copernicus University, 85094 Bydgoszcz, PolandANMCO Research Center, Fondazione per il Tuo cuore, 50121 Florence, ItalyCatholic University of the Sacred Heart, 00168 Rome, ItalyCatholic University of the Sacred Heart, 00168 Rome, ItalyAcute coronary syndromes (ACS) are a global leading cause of death. These syndromes show heterogeneity in presentation, mechanisms, outcomes and responses to treatment. Precision medicine aims to identify and synthesize unique features in individuals, translating the acquired data into improved personalised interventions. Current precision treatments of ACS include immediate coronary revascularisation driven by ECG ST-segment elevation, early coronary angiography based on elevated blood cardiac troponins in patients without ST-segment elevation, and duration of intensified antithrombotic therapy according to bleeding risk scores. Phenotypically stratified analyses of multi-omic datasets are urgently needed to further refine and couple the diagnosis and treatment of these potentially life-threatening conditions. We provide definitions, examples and possible ways to advance precision treatments of ACS.https://www.mdpi.com/2077-0383/10/8/1755acute coronary syndromesprecisionphenomappingomic technologiestreatmentsoutcomes |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Felicita Andreotti Adelaide Iervolino Eliano Pio Navarese Aldo Pietro Maggioni Filippo Crea Giovanni Scambia |
spellingShingle |
Felicita Andreotti Adelaide Iervolino Eliano Pio Navarese Aldo Pietro Maggioni Filippo Crea Giovanni Scambia Precision Phenomapping of Acute Coronary Syndromes to Improve Patient Outcomes Journal of Clinical Medicine acute coronary syndromes precision phenomapping omic technologies treatments outcomes |
author_facet |
Felicita Andreotti Adelaide Iervolino Eliano Pio Navarese Aldo Pietro Maggioni Filippo Crea Giovanni Scambia |
author_sort |
Felicita Andreotti |
title |
Precision Phenomapping of Acute Coronary Syndromes to Improve Patient Outcomes |
title_short |
Precision Phenomapping of Acute Coronary Syndromes to Improve Patient Outcomes |
title_full |
Precision Phenomapping of Acute Coronary Syndromes to Improve Patient Outcomes |
title_fullStr |
Precision Phenomapping of Acute Coronary Syndromes to Improve Patient Outcomes |
title_full_unstemmed |
Precision Phenomapping of Acute Coronary Syndromes to Improve Patient Outcomes |
title_sort |
precision phenomapping of acute coronary syndromes to improve patient outcomes |
publisher |
MDPI AG |
series |
Journal of Clinical Medicine |
issn |
2077-0383 |
publishDate |
2021-04-01 |
description |
Acute coronary syndromes (ACS) are a global leading cause of death. These syndromes show heterogeneity in presentation, mechanisms, outcomes and responses to treatment. Precision medicine aims to identify and synthesize unique features in individuals, translating the acquired data into improved personalised interventions. Current precision treatments of ACS include immediate coronary revascularisation driven by ECG ST-segment elevation, early coronary angiography based on elevated blood cardiac troponins in patients without ST-segment elevation, and duration of intensified antithrombotic therapy according to bleeding risk scores. Phenotypically stratified analyses of multi-omic datasets are urgently needed to further refine and couple the diagnosis and treatment of these potentially life-threatening conditions. We provide definitions, examples and possible ways to advance precision treatments of ACS. |
topic |
acute coronary syndromes precision phenomapping omic technologies treatments outcomes |
url |
https://www.mdpi.com/2077-0383/10/8/1755 |
work_keys_str_mv |
AT felicitaandreotti precisionphenomappingofacutecoronarysyndromestoimprovepatientoutcomes AT adelaideiervolino precisionphenomappingofacutecoronarysyndromestoimprovepatientoutcomes AT elianopionavarese precisionphenomappingofacutecoronarysyndromestoimprovepatientoutcomes AT aldopietromaggioni precisionphenomappingofacutecoronarysyndromestoimprovepatientoutcomes AT filippocrea precisionphenomappingofacutecoronarysyndromestoimprovepatientoutcomes AT giovanniscambia precisionphenomappingofacutecoronarysyndromestoimprovepatientoutcomes |
_version_ |
1721521669594415104 |