OXIDATIVE AND ANTI-OXIDATIVE EFFECT OF ANESTHESIA COMPOUNDS (KETAMINE AND XYLAZINE) ON THE RABBIT BLOOD SAMPLE USING ELECTROCHEMICAL METHOD

• Main Authors: Dunya Ali MUSTAFA, Bahaa Hadi MOHAMMED, Muhammed Mizher RADHI
• Format: Article
• Language: English
• Published: Amaltea Medical Publishing House 2020-06-01
• Series: Romanian Journal of Neurology
• Subjects: cyclic voltammetry; ketamine; xylazine; rabbit; blood; redox process
• Online Access: https://rjn.com.ro/articles/2020.2/RJN_2020_2_Art-04.pdf

Ketamine (KN) and xylazine (XZ) are one of the famous anesthesias using for the animal. The electrochemical properties of the KN and XZ compounds in the rbbit blood samples were studied by cyclic voltammetric (CV) technique using glassy carbon electrode (GCE). The study was included different concentrations, pH, scan rates, interferences between them (KN and XZ) and reliability (stability). The oxidation-reduction current peaks was studied of the KN and XZ alone and both (mixed) in the blood medium to determine the effect of these compounds on the blood components. It was found the oxidation- reduction current peaks for mixed of KN and XZ in blood medium at 0.1 and -0.8 V respectively, and the oxidation peak was enhanced in acidic pH (3), while the reduction peaks was enhanced in alkaline pH (8). Also, the mixing of KN and XZ in blood medium was acted to decrease the oxidation peak and enhance the reduction peak, so it can be said that mixing is best to work in the animal state.