GWAS of mosaic loss of chromosome Y highlights genetic effects on blood cell differentiation

Mosaic loss of chromosome Y (mLOY) is associated with age and smoking but also genetic factors play a role. Here, Terao et al. perform GWAS for mLOY in 95,380 Japanese men and identify 46 loci that overlap with hematopoietic stem cell enhancers and transcription factor binding sites critical for hem...

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Main Authors:	Chikashi Terao, Yukihide Momozawa, Kazuyoshi Ishigaki, Eiryo Kawakami, Masato Akiyama, Po-Ru Loh, Giulio Genovese, Hiroki Sugishita, Tazro Ohta, Makoto Hirata, John R. B. Perry, Koichi Matsuda, Yoshinori Murakami, Michiaki Kubo, Yoichiro Kamatani
Format:	Article
Language:	English
Published:	Nature Publishing Group 2019-10-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-019-12705-5

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spelling	doaj-4842027f92a24fc0962b7e4177ab2cdc2021-05-11T12:06:24ZengNature Publishing GroupNature Communications2041-17232019-10-0110111010.1038/s41467-019-12705-5GWAS of mosaic loss of chromosome Y highlights genetic effects on blood cell differentiationChikashi Terao0Yukihide Momozawa1Kazuyoshi Ishigaki2Eiryo Kawakami3Masato Akiyama4Po-Ru Loh5Giulio Genovese6Hiroki Sugishita7Tazro Ohta8Makoto Hirata9John R. B. Perry10Koichi Matsuda11Yoshinori Murakami12Michiaki Kubo13Yoichiro Kamatani14Laboratory for Statistical and Translational Genetics, RIKEN Center for Integrative Medical SciencesLaboratory for Genotyping Development, RIKEN Center for Integrative Medical SciencesLaboratory for Statistical and Translational Genetics, RIKEN Center for Integrative Medical SciencesHealthcare and Medical Data Driven AI based Predictive Reasoning Development Unit, Medical Sciences Innovation Hub Program (MIH), RIKENLaboratory for Statistical and Translational Genetics, RIKEN Center for Integrative Medical SciencesDivision of Genetics, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical SchoolProgram in Medical and Population Genetics, Broad Institute of MIT and HarvardLaboratory for Developmental Genetics, RIKEN Center for Integrative Medical Science (IMS)Database Center for Life Science, Joint Support-Center for Data Science Research, Research Organization of Information and SystemsLaboratory of Genome Technology, Human Genome Center, Institute of Medical Science, The University of TokyoMRC Epidemiology Unit, School of Clinical Medicine, University of CambridgeLaboratory of Genome Technology, Human Genome Center, Institute of Medical Science, The University of TokyoDivision of Molecular Pathology, Institute of Medical Science, The University of TokyoLaboratory for Genotyping Development, RIKEN Center for Integrative Medical SciencesLaboratory for Statistical and Translational Genetics, RIKEN Center for Integrative Medical SciencesMosaic loss of chromosome Y (mLOY) is associated with age and smoking but also genetic factors play a role. Here, Terao et al. perform GWAS for mLOY in 95,380 Japanese men and identify 46 loci that overlap with hematopoietic stem cell enhancers and transcription factor binding sites critical for hematopoiesis.https://doi.org/10.1038/s41467-019-12705-5
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Chikashi Terao Yukihide Momozawa Kazuyoshi Ishigaki Eiryo Kawakami Masato Akiyama Po-Ru Loh Giulio Genovese Hiroki Sugishita Tazro Ohta Makoto Hirata John R. B. Perry Koichi Matsuda Yoshinori Murakami Michiaki Kubo Yoichiro Kamatani
spellingShingle	Chikashi Terao Yukihide Momozawa Kazuyoshi Ishigaki Eiryo Kawakami Masato Akiyama Po-Ru Loh Giulio Genovese Hiroki Sugishita Tazro Ohta Makoto Hirata John R. B. Perry Koichi Matsuda Yoshinori Murakami Michiaki Kubo Yoichiro Kamatani GWAS of mosaic loss of chromosome Y highlights genetic effects on blood cell differentiation Nature Communications
author_facet	Chikashi Terao Yukihide Momozawa Kazuyoshi Ishigaki Eiryo Kawakami Masato Akiyama Po-Ru Loh Giulio Genovese Hiroki Sugishita Tazro Ohta Makoto Hirata John R. B. Perry Koichi Matsuda Yoshinori Murakami Michiaki Kubo Yoichiro Kamatani
author_sort	Chikashi Terao
title	GWAS of mosaic loss of chromosome Y highlights genetic effects on blood cell differentiation
title_short	GWAS of mosaic loss of chromosome Y highlights genetic effects on blood cell differentiation
title_full	GWAS of mosaic loss of chromosome Y highlights genetic effects on blood cell differentiation
title_fullStr	GWAS of mosaic loss of chromosome Y highlights genetic effects on blood cell differentiation
title_full_unstemmed	GWAS of mosaic loss of chromosome Y highlights genetic effects on blood cell differentiation
title_sort	gwas of mosaic loss of chromosome y highlights genetic effects on blood cell differentiation
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2019-10-01
description	Mosaic loss of chromosome Y (mLOY) is associated with age and smoking but also genetic factors play a role. Here, Terao et al. perform GWAS for mLOY in 95,380 Japanese men and identify 46 loci that overlap with hematopoietic stem cell enhancers and transcription factor binding sites critical for hematopoiesis.
url	https://doi.org/10.1038/s41467-019-12705-5
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GWAS of mosaic loss of chromosome Y highlights genetic effects on blood cell differentiation

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